Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients
Summary Background & aims High protein diets have been shown to improve hepatic steatosis in rodent models and in high-fat fed humans. We therefore evaluated the effects of a protein supplementation on intrahepatocellular lipids (IHCL), and fasting plasma triglycerides in obese non diabetic wome...
Gespeichert in:
| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-08, Vol.30 (4), p.494-498 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 498 |
|---|---|
| container_issue | 4 |
| container_start_page | 494 |
| container_title | Clinical nutrition (Edinburgh, Scotland) |
| container_volume | 30 |
| creator | Bortolotti, Murielle Maiolo, Elena Corazza, Mattia Van Dijke, Eveline Schneiter, Philippe Boss, Andreas Carrel, Guillaume Giusti, Vittorio Lê, Kim-Anne Quo Chong, Daniel Guae Buehler, Tania Kreis, Roland Boesch, Chris Tappy, Luc |
| description | Summary Background & aims High protein diets have been shown to improve hepatic steatosis in rodent models and in high-fat fed humans. We therefore evaluated the effects of a protein supplementation on intrahepatocellular lipids (IHCL), and fasting plasma triglycerides in obese non diabetic women. Methods Eleven obese women received a 60 g/day whey protein supplement (WPS) for 4-weeks, while otherwise nourished on a spontaneous diet, IHCL concentrations, visceral body fat, total liver volume (MR), fasting total-triglyceride and cholesterol concentrations, glucose tolerance (standard 75 g OGTT), insulin sensitivity (HOMA IS index), creatinine clearance, blood pressure and body composition (bio-impedance analysis) were assessed before and after 4-week WPS. Results IHCL were positively correlated with visceral fat and total liver volume at inclusion. WPS decreased significantly IHCL by 20.8 ± 7.7%, fasting total TG by 15 ± 6.9%, and total cholesterol by 7.3 ± 2.7%. WPS slightly increased fat free mass from 54.8 ± 2.2 kg to 56.7 ± 2.5 kg, p = 0.005). Visceral fat, total liver volume, glucose tolerance, creatinine clearance and insulin sensitivity were not changed. Conclusions WPS improves hepatic steatosis and plasma lipid profiles in obese non diabetic patients, without adverse effects on glucose tolerance or creatinine clearance. Trial Number NCT00870077, ClinicalTrials.gov |
| doi_str_mv | 10.1016/j.clnu.2011.01.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_880140046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0261561411000082</els_id><sourcerecordid>880140046</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-90cae9ab5d8cc6be611af3881c2ed2bad72a07f4a2337777fb047bcc1ca159ce3</originalsourceid><addsrcrecordid>eNp9kk2LFDEQhoMo7rj6BzxILuKpx6p0dzoNIsiyrsKCB_Uc0-kKmzH9YdKtzL83zYwreDAU5FDPW1W8VYw9R9gjoHx92NswrnsBiHvIAfIB22FdigJbVT5kOxASi1pidcGepHQAgLps1GN2IVAoJVHs2Ldr58guiU-OG_7rjo58jtNCfuRpnedAA42LWfw08hx-XKK5o9ksk6UQ1mAiD372fcopPnWUiDsaTCCeGZ-l6Sl75ExI9Oz8X7Kv76-_XH0obj_dfLx6d1vYGuRStGANtaare2Wt7EgiGlcqhVZQLzrTN8JA4yojyrLJz3VQNZ21aA3WraXykr061c3j_1gpLXrwaRvSjDStSSsFWAFUMpPiRNo4pRTJ6Tn6wcSjRtCbsfqgN2P1ZqyGHLCJXpzLr91A_b3kj5MZeHkGTLImuGhG69NfrsrNpWoz9-bEUTbjp6eok81GWep9zIvQ_eT_P8fbf-Q2-NHnjt_pSOkwrXHMNmvUSWjQn7cT2C4AMW8flCh_A1vYrYE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>880140046</pqid></control><display><type>article</type><title>Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bortolotti, Murielle ; Maiolo, Elena ; Corazza, Mattia ; Van Dijke, Eveline ; Schneiter, Philippe ; Boss, Andreas ; Carrel, Guillaume ; Giusti, Vittorio ; Lê, Kim-Anne ; Quo Chong, Daniel Guae ; Buehler, Tania ; Kreis, Roland ; Boesch, Chris ; Tappy, Luc</creator><creatorcontrib>Bortolotti, Murielle ; Maiolo, Elena ; Corazza, Mattia ; Van Dijke, Eveline ; Schneiter, Philippe ; Boss, Andreas ; Carrel, Guillaume ; Giusti, Vittorio ; Lê, Kim-Anne ; Quo Chong, Daniel Guae ; Buehler, Tania ; Kreis, Roland ; Boesch, Chris ; Tappy, Luc</creatorcontrib><description>Summary Background & aims High protein diets have been shown to improve hepatic steatosis in rodent models and in high-fat fed humans. We therefore evaluated the effects of a protein supplementation on intrahepatocellular lipids (IHCL), and fasting plasma triglycerides in obese non diabetic women. Methods Eleven obese women received a 60 g/day whey protein supplement (WPS) for 4-weeks, while otherwise nourished on a spontaneous diet, IHCL concentrations, visceral body fat, total liver volume (MR), fasting total-triglyceride and cholesterol concentrations, glucose tolerance (standard 75 g OGTT), insulin sensitivity (HOMA IS index), creatinine clearance, blood pressure and body composition (bio-impedance analysis) were assessed before and after 4-week WPS. Results IHCL were positively correlated with visceral fat and total liver volume at inclusion. WPS decreased significantly IHCL by 20.8 ± 7.7%, fasting total TG by 15 ± 6.9%, and total cholesterol by 7.3 ± 2.7%. WPS slightly increased fat free mass from 54.8 ± 2.2 kg to 56.7 ± 2.5 kg, p = 0.005). Visceral fat, total liver volume, glucose tolerance, creatinine clearance and insulin sensitivity were not changed. Conclusions WPS improves hepatic steatosis and plasma lipid profiles in obese non diabetic patients, without adverse effects on glucose tolerance or creatinine clearance. Trial Number NCT00870077, ClinicalTrials.gov</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2011.01.006</identifier><identifier>PMID: 21288612</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Amino Acids - drug effects ; Biological and medical sciences ; Blood Glucose - analysis ; Blood Pressure - drug effects ; Body Composition - drug effects ; Cholesterol - blood ; Chromium ; Creatinine - metabolism ; Diet ; Dietary proteins ; Dietary Supplements ; Fasting ; Fatty Liver - drug therapy ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Insulin Resistance ; Intra-Abdominal Fat - metabolism ; Liver - metabolism ; Medical sciences ; Metabolic diseases ; Milk Proteins - pharmacology ; Nicotinic Acids ; Non-alcoholic fatty liver disease ; Obesity ; Obesity - drug therapy ; Organ Size ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Whey Proteins</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2011-08, Vol.30 (4), p.494-498</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-90cae9ab5d8cc6be611af3881c2ed2bad72a07f4a2337777fb047bcc1ca159ce3</citedby><cites>FETCH-LOGICAL-c506t-90cae9ab5d8cc6be611af3881c2ed2bad72a07f4a2337777fb047bcc1ca159ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561411000082$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24400689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21288612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bortolotti, Murielle</creatorcontrib><creatorcontrib>Maiolo, Elena</creatorcontrib><creatorcontrib>Corazza, Mattia</creatorcontrib><creatorcontrib>Van Dijke, Eveline</creatorcontrib><creatorcontrib>Schneiter, Philippe</creatorcontrib><creatorcontrib>Boss, Andreas</creatorcontrib><creatorcontrib>Carrel, Guillaume</creatorcontrib><creatorcontrib>Giusti, Vittorio</creatorcontrib><creatorcontrib>Lê, Kim-Anne</creatorcontrib><creatorcontrib>Quo Chong, Daniel Guae</creatorcontrib><creatorcontrib>Buehler, Tania</creatorcontrib><creatorcontrib>Kreis, Roland</creatorcontrib><creatorcontrib>Boesch, Chris</creatorcontrib><creatorcontrib>Tappy, Luc</creatorcontrib><title>Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims High protein diets have been shown to improve hepatic steatosis in rodent models and in high-fat fed humans. We therefore evaluated the effects of a protein supplementation on intrahepatocellular lipids (IHCL), and fasting plasma triglycerides in obese non diabetic women. Methods Eleven obese women received a 60 g/day whey protein supplement (WPS) for 4-weeks, while otherwise nourished on a spontaneous diet, IHCL concentrations, visceral body fat, total liver volume (MR), fasting total-triglyceride and cholesterol concentrations, glucose tolerance (standard 75 g OGTT), insulin sensitivity (HOMA IS index), creatinine clearance, blood pressure and body composition (bio-impedance analysis) were assessed before and after 4-week WPS. Results IHCL were positively correlated with visceral fat and total liver volume at inclusion. WPS decreased significantly IHCL by 20.8 ± 7.7%, fasting total TG by 15 ± 6.9%, and total cholesterol by 7.3 ± 2.7%. WPS slightly increased fat free mass from 54.8 ± 2.2 kg to 56.7 ± 2.5 kg, p = 0.005). Visceral fat, total liver volume, glucose tolerance, creatinine clearance and insulin sensitivity were not changed. Conclusions WPS improves hepatic steatosis and plasma lipid profiles in obese non diabetic patients, without adverse effects on glucose tolerance or creatinine clearance. Trial Number NCT00870077, ClinicalTrials.gov</description><subject>Adult</subject><subject>Amino Acids - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure - drug effects</subject><subject>Body Composition - drug effects</subject><subject>Cholesterol - blood</subject><subject>Chromium</subject><subject>Creatinine - metabolism</subject><subject>Diet</subject><subject>Dietary proteins</subject><subject>Dietary Supplements</subject><subject>Fasting</subject><subject>Fatty Liver - drug therapy</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Milk Proteins - pharmacology</subject><subject>Nicotinic Acids</subject><subject>Non-alcoholic fatty liver disease</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Organ Size</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Whey Proteins</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhoMo7rj6BzxILuKpx6p0dzoNIsiyrsKCB_Uc0-kKmzH9YdKtzL83zYwreDAU5FDPW1W8VYw9R9gjoHx92NswrnsBiHvIAfIB22FdigJbVT5kOxASi1pidcGepHQAgLps1GN2IVAoJVHs2Ldr58guiU-OG_7rjo58jtNCfuRpnedAA42LWfw08hx-XKK5o9ksk6UQ1mAiD372fcopPnWUiDsaTCCeGZ-l6Sl75ExI9Oz8X7Kv76-_XH0obj_dfLx6d1vYGuRStGANtaare2Wt7EgiGlcqhVZQLzrTN8JA4yojyrLJz3VQNZ21aA3WraXykr061c3j_1gpLXrwaRvSjDStSSsFWAFUMpPiRNo4pRTJ6Tn6wcSjRtCbsfqgN2P1ZqyGHLCJXpzLr91A_b3kj5MZeHkGTLImuGhG69NfrsrNpWoz9-bEUTbjp6eok81GWep9zIvQ_eT_P8fbf-Q2-NHnjt_pSOkwrXHMNmvUSWjQn7cT2C4AMW8flCh_A1vYrYE</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Bortolotti, Murielle</creator><creator>Maiolo, Elena</creator><creator>Corazza, Mattia</creator><creator>Van Dijke, Eveline</creator><creator>Schneiter, Philippe</creator><creator>Boss, Andreas</creator><creator>Carrel, Guillaume</creator><creator>Giusti, Vittorio</creator><creator>Lê, Kim-Anne</creator><creator>Quo Chong, Daniel Guae</creator><creator>Buehler, Tania</creator><creator>Kreis, Roland</creator><creator>Boesch, Chris</creator><creator>Tappy, Luc</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients</title><author>Bortolotti, Murielle ; Maiolo, Elena ; Corazza, Mattia ; Van Dijke, Eveline ; Schneiter, Philippe ; Boss, Andreas ; Carrel, Guillaume ; Giusti, Vittorio ; Lê, Kim-Anne ; Quo Chong, Daniel Guae ; Buehler, Tania ; Kreis, Roland ; Boesch, Chris ; Tappy, Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-90cae9ab5d8cc6be611af3881c2ed2bad72a07f4a2337777fb047bcc1ca159ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Amino Acids - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure - drug effects</topic><topic>Body Composition - drug effects</topic><topic>Cholesterol - blood</topic><topic>Chromium</topic><topic>Creatinine - metabolism</topic><topic>Diet</topic><topic>Dietary proteins</topic><topic>Dietary Supplements</topic><topic>Fasting</topic><topic>Fatty Liver - drug therapy</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Milk Proteins - pharmacology</topic><topic>Nicotinic Acids</topic><topic>Non-alcoholic fatty liver disease</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Organ Size</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Whey Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bortolotti, Murielle</creatorcontrib><creatorcontrib>Maiolo, Elena</creatorcontrib><creatorcontrib>Corazza, Mattia</creatorcontrib><creatorcontrib>Van Dijke, Eveline</creatorcontrib><creatorcontrib>Schneiter, Philippe</creatorcontrib><creatorcontrib>Boss, Andreas</creatorcontrib><creatorcontrib>Carrel, Guillaume</creatorcontrib><creatorcontrib>Giusti, Vittorio</creatorcontrib><creatorcontrib>Lê, Kim-Anne</creatorcontrib><creatorcontrib>Quo Chong, Daniel Guae</creatorcontrib><creatorcontrib>Buehler, Tania</creatorcontrib><creatorcontrib>Kreis, Roland</creatorcontrib><creatorcontrib>Boesch, Chris</creatorcontrib><creatorcontrib>Tappy, Luc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bortolotti, Murielle</au><au>Maiolo, Elena</au><au>Corazza, Mattia</au><au>Van Dijke, Eveline</au><au>Schneiter, Philippe</au><au>Boss, Andreas</au><au>Carrel, Guillaume</au><au>Giusti, Vittorio</au><au>Lê, Kim-Anne</au><au>Quo Chong, Daniel Guae</au><au>Buehler, Tania</au><au>Kreis, Roland</au><au>Boesch, Chris</au><au>Tappy, Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>30</volume><issue>4</issue><spage>494</spage><epage>498</epage><pages>494-498</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Summary Background & aims High protein diets have been shown to improve hepatic steatosis in rodent models and in high-fat fed humans. We therefore evaluated the effects of a protein supplementation on intrahepatocellular lipids (IHCL), and fasting plasma triglycerides in obese non diabetic women. Methods Eleven obese women received a 60 g/day whey protein supplement (WPS) for 4-weeks, while otherwise nourished on a spontaneous diet, IHCL concentrations, visceral body fat, total liver volume (MR), fasting total-triglyceride and cholesterol concentrations, glucose tolerance (standard 75 g OGTT), insulin sensitivity (HOMA IS index), creatinine clearance, blood pressure and body composition (bio-impedance analysis) were assessed before and after 4-week WPS. Results IHCL were positively correlated with visceral fat and total liver volume at inclusion. WPS decreased significantly IHCL by 20.8 ± 7.7%, fasting total TG by 15 ± 6.9%, and total cholesterol by 7.3 ± 2.7%. WPS slightly increased fat free mass from 54.8 ± 2.2 kg to 56.7 ± 2.5 kg, p = 0.005). Visceral fat, total liver volume, glucose tolerance, creatinine clearance and insulin sensitivity were not changed. Conclusions WPS improves hepatic steatosis and plasma lipid profiles in obese non diabetic patients, without adverse effects on glucose tolerance or creatinine clearance. Trial Number NCT00870077, ClinicalTrials.gov</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21288612</pmid><doi>10.1016/j.clnu.2011.01.006</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2011-08, Vol.30 (4), p.494-498 |
| issn | 0261-5614 1532-1983 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_880140046 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Amino Acids - drug effects Biological and medical sciences Blood Glucose - analysis Blood Pressure - drug effects Body Composition - drug effects Cholesterol - blood Chromium Creatinine - metabolism Diet Dietary proteins Dietary Supplements Fasting Fatty Liver - drug therapy Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glucose tolerance Glucose Tolerance Test Humans Insulin - blood Insulin Resistance Intra-Abdominal Fat - metabolism Liver - metabolism Medical sciences Metabolic diseases Milk Proteins - pharmacology Nicotinic Acids Non-alcoholic fatty liver disease Obesity Obesity - drug therapy Organ Size Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Whey Proteins |
| title | Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T13%3A03%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20whey%20protein%20supplementation%20on%20intrahepatocellular%20lipids%20in%20obese%20female%20patients&rft.jtitle=Clinical%20nutrition%20(Edinburgh,%20Scotland)&rft.au=Bortolotti,%20Murielle&rft.date=2011-08-01&rft.volume=30&rft.issue=4&rft.spage=494&rft.epage=498&rft.pages=494-498&rft.issn=0261-5614&rft.eissn=1532-1983&rft.coden=CLNUDP&rft_id=info:doi/10.1016/j.clnu.2011.01.006&rft_dat=%3Cproquest_cross%3E880140046%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=880140046&rft_id=info:pmid/21288612&rft_els_id=1_s2_0_S0261561411000082&rfr_iscdi=true |