A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice
Summary Background & aims Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammat...
Gespeichert in:
| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-08, Vol.30 (4), p.513-516 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 516 |
|---|---|
| container_issue | 4 |
| container_start_page | 513 |
| container_title | Clinical nutrition (Edinburgh, Scotland) |
| container_volume | 30 |
| creator | Nakamura, Kentaro Ogawa, Saori Dairiki, Kazuo Fukatsu, Kazuhiko Sasaki, Hajime Kaneko, Tetsuo Yamaji, Taketo |
| description | Summary Background & aims Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammatory effects in a concanavalin A-induced hepatitis model. Here, we investigated whether the immune-modulating diet (IMD), could prevent systemic inflammation, thereby improving survival in a gut I/R model. Methods Mice were randomized into control enteral diet ( n = 58) or IMD ( n = 56) for 2 weeks’ feeding. In experiment 1, 39 mice underwent 45 min of gut ischemia, and were sacrificed at 3 h after reperfusion to collect blood samples. Plasma IL-6 and glucose levels were measured. In experiment 2, 75 mice underwent 60 min of ischemia, and their survival was observed until 48 h. Results Plasma IL-6 and glucose levels of the IMD group were significantly lower than those of control mice. In association with these changes, the IMD improved survival rate at early time points (12 and 30 h) after gut I/R ( p |
| doi_str_mv | 10.1016/j.clnu.2011.01.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_880140045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0261561411000045</els_id><sourcerecordid>880140045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-214771f0b21368c6384aa3c89266eef88fbb93ae8d9cf5adddb7ca06e8d987553</originalsourceid><addsrcrecordid>eNp9Uk2LFDEQbURxZ1f_gAfJRbxsj0n6Kw2ysCyuCgse1HNIJ9U76U0nYz4c2j_i3zXNjAoehIKCyquXqnqvKF4QvCWYtG-mrTQ2bSkmZItzYPqo2JCmoiXpWfW42GDakrJpSX1WnIcwYYybqmNPizNKKCN9X2-Kn9fIwgHpeU4WytmpZETU9h4pDRGB9VruQKGDjjt02MFS7hblnVl-5OIe9lEruEQj-BlszKVZm4dLJKxCOrhZmJiMC4BEjGCTiBDQfYr5LZPOWpQe9uDHFLSzSNsp-SWnTCLhWfFkFCbA81O-KL7evvty86G8-_T-4831XSnrGseSkrrryIgHSqqWybZitRCVZD1tW4CRsXEY-koAU70cG6GUGjopcLsWWNc01UXx-si79-5bghD5nKcDY4QFlwJnDJMa43pF0iNSeheCh5HvvZ6FXzjBfNWDT3zVg696cJwD09z08kSfhhnUn5bfAmTAqxNABCnM6IWVOvzF5S1x21cZ9_aIg3yM7xo8D1KDlaC0Bxm5cvr_c1z90y6Ntjr_-AALhMklb_OZOeGBcsw_r85ZjUNINs26_S84vsGt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>880140045</pqid></control><display><type>article</type><title>A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Nakamura, Kentaro ; Ogawa, Saori ; Dairiki, Kazuo ; Fukatsu, Kazuhiko ; Sasaki, Hajime ; Kaneko, Tetsuo ; Yamaji, Taketo</creator><creatorcontrib>Nakamura, Kentaro ; Ogawa, Saori ; Dairiki, Kazuo ; Fukatsu, Kazuhiko ; Sasaki, Hajime ; Kaneko, Tetsuo ; Yamaji, Taketo</creatorcontrib><description>Summary Background & aims Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammatory effects in a concanavalin A-induced hepatitis model. Here, we investigated whether the immune-modulating diet (IMD), could prevent systemic inflammation, thereby improving survival in a gut I/R model. Methods Mice were randomized into control enteral diet ( n = 58) or IMD ( n = 56) for 2 weeks’ feeding. In experiment 1, 39 mice underwent 45 min of gut ischemia, and were sacrificed at 3 h after reperfusion to collect blood samples. Plasma IL-6 and glucose levels were measured. In experiment 2, 75 mice underwent 60 min of ischemia, and their survival was observed until 48 h. Results Plasma IL-6 and glucose levels of the IMD group were significantly lower than those of control mice. In association with these changes, the IMD improved survival rate at early time points (12 and 30 h) after gut I/R ( p < 0.05, χ2 test). Conclusions Nutritional management with the IMD may be useful for preventing systemic inflammatory response after gut I/R.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2011.01.002</identifier><identifier>PMID: 21281994</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Cardiology. Vascular system ; Dairy Products - analysis ; Diet ; Disease Models, Animal ; Enteral diet ; Enteral Nutrition - methods ; Feeding. Feeding behavior ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Gastrointestinal Tract - physiopathology ; Hydrolysis ; Immunonutrition ; Inflammation ; Inflammation - prevention & control ; Interleukin-6 - blood ; Isomaltose - analogs & derivatives ; Isomaltose - pharmacology ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Milk Proteins - administration & dosage ; Multiple Organ Failure - prevention & control ; Reperfusion Injury - diet therapy ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Whey Proteins</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2011-08, Vol.30 (4), p.513-516</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-214771f0b21368c6384aa3c89266eef88fbb93ae8d9cf5adddb7ca06e8d987553</citedby><cites>FETCH-LOGICAL-c440t-214771f0b21368c6384aa3c89266eef88fbb93ae8d9cf5adddb7ca06e8d987553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2011.01.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24400693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21281994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Kentaro</creatorcontrib><creatorcontrib>Ogawa, Saori</creatorcontrib><creatorcontrib>Dairiki, Kazuo</creatorcontrib><creatorcontrib>Fukatsu, Kazuhiko</creatorcontrib><creatorcontrib>Sasaki, Hajime</creatorcontrib><creatorcontrib>Kaneko, Tetsuo</creatorcontrib><creatorcontrib>Yamaji, Taketo</creatorcontrib><title>A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammatory effects in a concanavalin A-induced hepatitis model. Here, we investigated whether the immune-modulating diet (IMD), could prevent systemic inflammation, thereby improving survival in a gut I/R model. Methods Mice were randomized into control enteral diet ( n = 58) or IMD ( n = 56) for 2 weeks’ feeding. In experiment 1, 39 mice underwent 45 min of gut ischemia, and were sacrificed at 3 h after reperfusion to collect blood samples. Plasma IL-6 and glucose levels were measured. In experiment 2, 75 mice underwent 60 min of ischemia, and their survival was observed until 48 h. Results Plasma IL-6 and glucose levels of the IMD group were significantly lower than those of control mice. In association with these changes, the IMD improved survival rate at early time points (12 and 30 h) after gut I/R ( p < 0.05, χ2 test). Conclusions Nutritional management with the IMD may be useful for preventing systemic inflammatory response after gut I/R.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Dairy Products - analysis</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Enteral diet</subject><subject>Enteral Nutrition - methods</subject><subject>Feeding. Feeding behavior</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal Tract - physiopathology</subject><subject>Hydrolysis</subject><subject>Immunonutrition</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Interleukin-6 - blood</subject><subject>Isomaltose - analogs & derivatives</subject><subject>Isomaltose - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Milk Proteins - administration & dosage</subject><subject>Multiple Organ Failure - prevention & control</subject><subject>Reperfusion Injury - diet therapy</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Whey Proteins</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2LFDEQbURxZ1f_gAfJRbxsj0n6Kw2ysCyuCgse1HNIJ9U76U0nYz4c2j_i3zXNjAoehIKCyquXqnqvKF4QvCWYtG-mrTQ2bSkmZItzYPqo2JCmoiXpWfW42GDakrJpSX1WnIcwYYybqmNPizNKKCN9X2-Kn9fIwgHpeU4WytmpZETU9h4pDRGB9VruQKGDjjt02MFS7hblnVl-5OIe9lEruEQj-BlszKVZm4dLJKxCOrhZmJiMC4BEjGCTiBDQfYr5LZPOWpQe9uDHFLSzSNsp-SWnTCLhWfFkFCbA81O-KL7evvty86G8-_T-4831XSnrGseSkrrryIgHSqqWybZitRCVZD1tW4CRsXEY-koAU70cG6GUGjopcLsWWNc01UXx-si79-5bghD5nKcDY4QFlwJnDJMa43pF0iNSeheCh5HvvZ6FXzjBfNWDT3zVg696cJwD09z08kSfhhnUn5bfAmTAqxNABCnM6IWVOvzF5S1x21cZ9_aIg3yM7xo8D1KDlaC0Bxm5cvr_c1z90y6Ntjr_-AALhMklb_OZOeGBcsw_r85ZjUNINs26_S84vsGt</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Nakamura, Kentaro</creator><creator>Ogawa, Saori</creator><creator>Dairiki, Kazuo</creator><creator>Fukatsu, Kazuhiko</creator><creator>Sasaki, Hajime</creator><creator>Kaneko, Tetsuo</creator><creator>Yamaji, Taketo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice</title><author>Nakamura, Kentaro ; Ogawa, Saori ; Dairiki, Kazuo ; Fukatsu, Kazuhiko ; Sasaki, Hajime ; Kaneko, Tetsuo ; Yamaji, Taketo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-214771f0b21368c6384aa3c89266eef88fbb93ae8d9cf5adddb7ca06e8d987553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Dairy Products - analysis</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Enteral diet</topic><topic>Enteral Nutrition - methods</topic><topic>Feeding. Feeding behavior</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastrointestinal Tract - physiopathology</topic><topic>Hydrolysis</topic><topic>Immunonutrition</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>Interleukin-6 - blood</topic><topic>Isomaltose - analogs & derivatives</topic><topic>Isomaltose - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Milk Proteins - administration & dosage</topic><topic>Multiple Organ Failure - prevention & control</topic><topic>Reperfusion Injury - diet therapy</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Whey Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Kentaro</creatorcontrib><creatorcontrib>Ogawa, Saori</creatorcontrib><creatorcontrib>Dairiki, Kazuo</creatorcontrib><creatorcontrib>Fukatsu, Kazuhiko</creatorcontrib><creatorcontrib>Sasaki, Hajime</creatorcontrib><creatorcontrib>Kaneko, Tetsuo</creatorcontrib><creatorcontrib>Yamaji, Taketo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Kentaro</au><au>Ogawa, Saori</au><au>Dairiki, Kazuo</au><au>Fukatsu, Kazuhiko</au><au>Sasaki, Hajime</au><au>Kaneko, Tetsuo</au><au>Yamaji, Taketo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>30</volume><issue>4</issue><spage>513</spage><epage>516</epage><pages>513-516</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Summary Background & aims Gut ischemia-reperfusion (I/R) is considered an important mechanism underlying multiple organ failure after severe surgical insults. We previously demonstrated an enteral diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose to have anti-inflammatory effects in a concanavalin A-induced hepatitis model. Here, we investigated whether the immune-modulating diet (IMD), could prevent systemic inflammation, thereby improving survival in a gut I/R model. Methods Mice were randomized into control enteral diet ( n = 58) or IMD ( n = 56) for 2 weeks’ feeding. In experiment 1, 39 mice underwent 45 min of gut ischemia, and were sacrificed at 3 h after reperfusion to collect blood samples. Plasma IL-6 and glucose levels were measured. In experiment 2, 75 mice underwent 60 min of ischemia, and their survival was observed until 48 h. Results Plasma IL-6 and glucose levels of the IMD group were significantly lower than those of control mice. In association with these changes, the IMD improved survival rate at early time points (12 and 30 h) after gut I/R ( p < 0.05, χ2 test). Conclusions Nutritional management with the IMD may be useful for preventing systemic inflammatory response after gut I/R.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21281994</pmid><doi>10.1016/j.clnu.2011.01.002</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2011-08, Vol.30 (4), p.513-516 |
| issn | 0261-5614 1532-1983 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_880140045 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Blood Glucose - analysis Cardiology. Vascular system Dairy Products - analysis Diet Disease Models, Animal Enteral diet Enteral Nutrition - methods Feeding. Feeding behavior Fermentation Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Gastrointestinal Tract - physiopathology Hydrolysis Immunonutrition Inflammation Inflammation - prevention & control Interleukin-6 - blood Isomaltose - analogs & derivatives Isomaltose - pharmacology Male Medical sciences Mice Mice, Inbred ICR Milk Proteins - administration & dosage Multiple Organ Failure - prevention & control Reperfusion Injury - diet therapy Vertebrates: anatomy and physiology, studies on body, several organs or systems Whey Proteins |
| title | A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T09%3A25%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20immune-modulating%20diet%20enriched%20with%20whey-hydrolyzed%20peptide,%20fermented%20milk,%20and%20isomaltulose%20attenuates%20gut%20ischemia-reperfusion%20injury%20in%20mice&rft.jtitle=Clinical%20nutrition%20(Edinburgh,%20Scotland)&rft.au=Nakamura,%20Kentaro&rft.date=2011-08-01&rft.volume=30&rft.issue=4&rft.spage=513&rft.epage=516&rft.pages=513-516&rft.issn=0261-5614&rft.eissn=1532-1983&rft.coden=CLNUDP&rft_id=info:doi/10.1016/j.clnu.2011.01.002&rft_dat=%3Cproquest_cross%3E880140045%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=880140045&rft_id=info:pmid/21281994&rft_els_id=S0261561411000045&rfr_iscdi=true |