Peptidome profiling of induced sputum by mesoporous silica beads and MALDI-TOF MS for non-invasive biomarker discovery of chronic inflammatory lung diseases

Induced sputum is recognized as being of increasing importance for the diagnosis and monitoring of chronic inflammatory lung diseases. The main purpose of this study is to provide a valid approach to better fractionate and characterize the still under‐estimated low‐molecular weight proteome of induc...

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Veröffentlicht in:	Proteomics (Weinheim) 2011-08, Vol.11 (16), p.3402-3414
Hauptverfasser:	Terracciano, Rosa, Preianò, Mariaimmacolata, Palladino, Grazia P., Carpagnano, Giovanna E., Barbaro, Maria P. Foschino, Pelaia, Girolamo, Savino, Rocco, Maselli, Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged alpha-Defensins - metabolism Analytical, structural and metabolic biochemistry Asthma Asthma - metabolism Biological and medical sciences biomarkers Biomarkers - analysis Biomarkers - chemistry Case-Control Studies Chronic obstructive pulmonary disease Female Fundamental and applied biological sciences. Psychology high-throughput screening Humans Induced sputum Inflammation Inflammatory diseases Leukocytes (neutrophilic) Lung diseases MALDI-TOF MS Male Microspheres Middle Aged Miscellaneous Molecular weight Peptide Peptides - analysis Peptides - chemistry Peptidomics Proteins Proteome - analysis Proteome - chemistry proteomics Proteomics - methods Pulmonary Disease, Chronic Obstructive - metabolism Reproducibility of Results Respiratory diseases Respiratory tract diseases Saliva - chemistry Saliva - metabolism Serine Silica Silicon Dioxide - chemistry Solid Phase Extraction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Sputum Sputum - chemistry Sputum - metabolism Technology
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