Highly Diastereoselective and Enantioselective Synthesis of α-Hydroxy β-Amino Acid Derivatives: Lewis Base Catalyzed Hydrosilylation of α-Acetoxy β-Enamino Esters

By design: A series of α‐acetoxy‐β‐enamino esters 1 were synthesized and then subjected to catalytic asymmetric hydrosilylation. In the presence of a chiral Lewis base catalyst, the reactions proceeded smoothly to provide a wide range of chiral α‐acetoxy β‐amino acid derivatives in high yields with...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-08, Vol.50 (32), p.7304-7307
Hauptverfasser:	Jiang, Yan, Chen, Xing, Zheng, Yongsheng, Xue, Zhouyang, Shu, Chang, Yuan, Weicheng, Zhang, Xiaomei
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - chemical synthesis Amino Acids - chemistry asymmetric catalysis Catalysis Esters Lewis bases Lewis Bases - chemistry organocatalysis Silicon - chemistry Stereoisomerism synthetic methods
Online-Zugang:	Volltext
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