Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease
The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high se...
Gespeichert in:
| Veröffentlicht in: | International journal for vitamin and nutrition research 2010-12, Vol.80 (6), p.369-377 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 377 |
|---|---|
| container_issue | 6 |
| container_start_page | 369 |
| container_title | International journal for vitamin and nutrition research |
| container_volume | 80 |
| creator | Muzáková, Vladimíra Kand'ár, Roman Meloun, Milan Skalický, Jirí Královec, Karel Záková, Pavla Vojtísek, Petr |
| description | The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n=91) and a control group of examined patients with coronary arteries with no stenosis (n=49)]. Between-group differences in continuous variables were analyzed with the Hotelling T2-test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes. |
| doi_str_mv | 10.1024/0300-9831/a000024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_879675912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>879675912</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-e956befe64f953538091d79e7072403f579df6b89c6d51b6a3adc93b34f86a2d3</originalsourceid><addsrcrecordid>eNo9kEtPwzAQhC0EoqXwA7gg3ziF-pHY8REqHpUqcYFztIk3IpA4wXZb9d-TqqV7Wa12ZjT6CLnl7IEzkc6ZZCwxueRzYOOI9IxMuVJpInLBz8n09J-QqxC-GZOa5-klmQiujci5npK4dBv0AWnVe48txKZ3tMS4RXR0aCF0QJ8wQlKB7yM6pOAsbVxE3-L6p3GJGi86jEZ0MdBtE78o2A24Cu0-tHfgdxT8aNhR2wSEgNfkooY24M1xz8jny_PH4i1Zvb8uF4-rpBqLxwRNpkqsUaW1yWQmc2a41QY10yJlss60sbUqc1Mpm_FSgQRbGVnKtM4VCCtn5P6QO_j-d40hFl0TKmxbcNivQ5Fro3RmuBiV_KCsfB-Cx7oYfNONzQvOij3rYs-y2LMsjqxHz90xfV12aE-Of7jyD18Ae4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>879675912</pqid></control><display><type>article</type><title>Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease</title><source>Hogrefe eContent</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Muzáková, Vladimíra ; Kand'ár, Roman ; Meloun, Milan ; Skalický, Jirí ; Královec, Karel ; Záková, Pavla ; Vojtísek, Petr</creator><creatorcontrib>Muzáková, Vladimíra ; Kand'ár, Roman ; Meloun, Milan ; Skalický, Jirí ; Královec, Karel ; Záková, Pavla ; Vojtísek, Petr</creatorcontrib><description>The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n=91) and a control group of examined patients with coronary arteries with no stenosis (n=49)]. Between-group differences in continuous variables were analyzed with the Hotelling T2-test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes.</description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831/a000024</identifier><identifier>PMID: 21792817</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Aged ; alpha-Tocopherol - blood ; beta Carotene - blood ; C-Reactive Protein - metabolism ; Cholesterol - blood ; Coronary Artery Disease - blood ; Female ; Humans ; Interleukin-6 - blood ; Male ; Malondialdehyde - blood ; Middle Aged ; Oxidative Stress - physiology ; Surveys and Questionnaires</subject><ispartof>International journal for vitamin and nutrition research, 2010-12, Vol.80 (6), p.369-377</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-e956befe64f953538091d79e7072403f579df6b89c6d51b6a3adc93b34f86a2d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21792817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muzáková, Vladimíra</creatorcontrib><creatorcontrib>Kand'ár, Roman</creatorcontrib><creatorcontrib>Meloun, Milan</creatorcontrib><creatorcontrib>Skalický, Jirí</creatorcontrib><creatorcontrib>Královec, Karel</creatorcontrib><creatorcontrib>Záková, Pavla</creatorcontrib><creatorcontrib>Vojtísek, Petr</creatorcontrib><title>Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n=91) and a control group of examined patients with coronary arteries with no stenosis (n=49)]. Between-group differences in continuous variables were analyzed with the Hotelling T2-test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes.</description><subject>Aged</subject><subject>alpha-Tocopherol - blood</subject><subject>beta Carotene - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cholesterol - blood</subject><subject>Coronary Artery Disease - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Oxidative Stress - physiology</subject><subject>Surveys and Questionnaires</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhC0EoqXwA7gg3ziF-pHY8REqHpUqcYFztIk3IpA4wXZb9d-TqqV7Wa12ZjT6CLnl7IEzkc6ZZCwxueRzYOOI9IxMuVJpInLBz8n09J-QqxC-GZOa5-klmQiujci5npK4dBv0AWnVe48txKZ3tMS4RXR0aCF0QJ8wQlKB7yM6pOAsbVxE3-L6p3GJGi86jEZ0MdBtE78o2A24Cu0-tHfgdxT8aNhR2wSEgNfkooY24M1xz8jny_PH4i1Zvb8uF4-rpBqLxwRNpkqsUaW1yWQmc2a41QY10yJlss60sbUqc1Mpm_FSgQRbGVnKtM4VCCtn5P6QO_j-d40hFl0TKmxbcNivQ5Fro3RmuBiV_KCsfB-Cx7oYfNONzQvOij3rYs-y2LMsjqxHz90xfV12aE-Of7jyD18Ae4w</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Muzáková, Vladimíra</creator><creator>Kand'ár, Roman</creator><creator>Meloun, Milan</creator><creator>Skalický, Jirí</creator><creator>Královec, Karel</creator><creator>Záková, Pavla</creator><creator>Vojtísek, Petr</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease</title><author>Muzáková, Vladimíra ; Kand'ár, Roman ; Meloun, Milan ; Skalický, Jirí ; Královec, Karel ; Záková, Pavla ; Vojtísek, Petr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-e956befe64f953538091d79e7072403f579df6b89c6d51b6a3adc93b34f86a2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>alpha-Tocopherol - blood</topic><topic>beta Carotene - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cholesterol - blood</topic><topic>Coronary Artery Disease - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Oxidative Stress - physiology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muzáková, Vladimíra</creatorcontrib><creatorcontrib>Kand'ár, Roman</creatorcontrib><creatorcontrib>Meloun, Milan</creatorcontrib><creatorcontrib>Skalický, Jirí</creatorcontrib><creatorcontrib>Královec, Karel</creatorcontrib><creatorcontrib>Záková, Pavla</creatorcontrib><creatorcontrib>Vojtísek, Petr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muzáková, Vladimíra</au><au>Kand'ár, Roman</au><au>Meloun, Milan</au><au>Skalický, Jirí</au><au>Královec, Karel</au><au>Záková, Pavla</au><au>Vojtísek, Petr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>80</volume><issue>6</issue><spage>369</spage><epage>377</epage><pages>369-377</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><abstract>The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n=91) and a control group of examined patients with coronary arteries with no stenosis (n=49)]. Between-group differences in continuous variables were analyzed with the Hotelling T2-test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes.</abstract><cop>Switzerland</cop><pmid>21792817</pmid><doi>10.1024/0300-9831/a000024</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9831 |
| ispartof | International journal for vitamin and nutrition research, 2010-12, Vol.80 (6), p.369-377 |
| issn | 0300-9831 1664-2821 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_879675912 |
| source | Hogrefe eContent; MEDLINE; Alma/SFX Local Collection |
| subjects | Aged alpha-Tocopherol - blood beta Carotene - blood C-Reactive Protein - metabolism Cholesterol - blood Coronary Artery Disease - blood Female Humans Interleukin-6 - blood Male Malondialdehyde - blood Middle Aged Oxidative Stress - physiology Surveys and Questionnaires |
| title | Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T03%3A10%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inverse%20correlation%20between%20plasma%20Beta-carotene%20and%20interleukin-6%20in%20patients%20with%20advanced%20coronary%20artery%20disease&rft.jtitle=International%20journal%20for%20vitamin%20and%20nutrition%20research&rft.au=Muz%C3%A1kov%C3%A1,%20Vladim%C3%ADra&rft.date=2010-12-01&rft.volume=80&rft.issue=6&rft.spage=369&rft.epage=377&rft.pages=369-377&rft.issn=0300-9831&rft.eissn=1664-2821&rft_id=info:doi/10.1024/0300-9831/a000024&rft_dat=%3Cproquest_cross%3E879675912%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=879675912&rft_id=info:pmid/21792817&rfr_iscdi=true |