Enhancement effect of N-methyl-N″-dodecylguanidine on the vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans

The alkylguanidium chain attached to the polyol lactone ring of niphimycin (NM) is considered a requisite for the fungicidal activity of NM characterized by vacuole membrane fragmentation and oxidative stress induction. The addition of N -methyl- N″ -dodecylguanidine to the medium can enhance the va...

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Veröffentlicht in:	Journal of antibiotics 2011-07, Vol.64 (7), p.469-474
Hauptverfasser:	Yutani, Masahiro, Ogita, Akira, Usuki, Yoshinosuke, Fujita, Ken-ichi, Tanaka, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/193 631/326/22/1292 631/80/313/1869 631/92/609 Amphotericin B - administration & dosage Amphotericin B - pharmacology Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Candida albicans - drug effects Dose-Response Relationship, Drug Drug Delivery Systems Drug Synergism Ergosterol - pharmacology Guanidines - administration & dosage Guanidines - chemistry Guanidines - pharmacology Hydrogen Peroxide - administration & dosage Hydrogen Peroxide - pharmacology Life Sciences Medicinal Chemistry Microbiology Organic Chemistry original-article Oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Vacuoles - drug effects
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