High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery

Genome‐wide association and linkage studies have identified multiple susceptibility loci for obesity. We hypothesized that such loci may affect weight loss outcomes following dietary or surgical weight loss interventions. A total of 1,001 white individuals with extreme obesity (BMI >35 kg/m2) who...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2011-08, Vol.19 (8), p.1676-1683
Hauptverfasser:	Still, Christopher D., Wood, G. Craig, Chu, Xin, Erdman, Robert, Manney, Christina H., Benotti, Peter N., Petrick, Anthony T., Strodel, William E., Mirshahi, Uyenlinh L., Mirshahi, Tooraj, Carey, David J., Gerhard, Glenn S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Adult Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO Body Mass Index Clinical outcomes Female Gastric Bypass Gastrointestinal surgery Genetics Genotype Homozygote Humans Intracellular Signaling Peptides and Proteins - genetics Male Membrane Proteins - genetics Middle Aged Neuropeptides - genetics Obesity Obesity - genetics Obesity - surgery Polymorphism, Single Nucleotide Proteins - genetics Receptor, Melanocortin, Type 4 - genetics Regression Analysis Weight Loss - genetics
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