Amelioration of Lipid Abnormalities by α‐Lipoic acid Through Antioxidative and Anti‐Inflammatory Effects
Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin‐resistant states of obesity and type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2011-08, Vol.19 (8), p.1647-1653 |
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| creator | Zhang, Yongyan Han, Ping Wu, Na He, Bing Lu, Yan Li, Shuwen Liu, Yang Zhao, Sheng Liu, Letong Li, Yan |
| description | Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin‐resistant states of obesity and type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia. α‐Lipoic acid (ALA) is a potent antioxidant with insulin sensitizing activity. However, it is not clear whether ALA is effective on lipid parameters in humans. This study has investigated 22 obese subjects with IGT (obese‐IGT), 13 of whom underwent 2‐week ALA treatment, 600 mg intravenously once daily. Before and after the treatment, euglycemic‐hyperinsulinemic clamps were used to measure insulin sensitivity. Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers were measured. After treatment of ALA in obese‐IGT patients, insulin sensitivity was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T‐Chol), low density lipoprotein‐cholesterol (LDL‐Chol), small dense LDL‐Chol (sd‐LDL), oxidized LDL‐Chol (ox‐LDL‐Chol), very low density lipoprotein‐cholesterol (VLDL‐Chol) were all significantly decreased (P < 0.01). At the same time, both plasma oxidative products (malondialdehyde (MDA), 8‐iso‐prostaglandin) and inflammatory markers (tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6)) were remarkably decreased (P < 0.01), while adiponectin was increased (P < 0.01). There are significant negative correlations between ISI and plasma FFAs, sd‐LDL‐Chol, ox‐LDL‐Chol, MDA, 8‐iso‐prostaglandin, TNF‐α, and IL‐6, and positive correlations with HDL‐Chol and adiponectin in obese‐IGT patients. The results indicate that short‐term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT. |
| doi_str_mv | 10.1038/oby.2011.121 |
| format | Article |
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Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia. α‐Lipoic acid (ALA) is a potent antioxidant with insulin sensitizing activity. However, it is not clear whether ALA is effective on lipid parameters in humans. This study has investigated 22 obese subjects with IGT (obese‐IGT), 13 of whom underwent 2‐week ALA treatment, 600 mg intravenously once daily. Before and after the treatment, euglycemic‐hyperinsulinemic clamps were used to measure insulin sensitivity. Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers were measured. After treatment of ALA in obese‐IGT patients, insulin sensitivity was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T‐Chol), low density lipoprotein‐cholesterol (LDL‐Chol), small dense LDL‐Chol (sd‐LDL), oxidized LDL‐Chol (ox‐LDL‐Chol), very low density lipoprotein‐cholesterol (VLDL‐Chol) were all significantly decreased (P < 0.01). At the same time, both plasma oxidative products (malondialdehyde (MDA), 8‐iso‐prostaglandin) and inflammatory markers (tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6)) were remarkably decreased (P < 0.01), while adiponectin was increased (P < 0.01). There are significant negative correlations between ISI and plasma FFAs, sd‐LDL‐Chol, ox‐LDL‐Chol, MDA, 8‐iso‐prostaglandin, TNF‐α, and IL‐6, and positive correlations with HDL‐Chol and adiponectin in obese‐IGT patients. The results indicate that short‐term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2011.121</identifier><identifier>PMID: 21593803</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adiponectin - blood ; Adult ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biomarkers - blood ; Glucose Intolerance - blood ; Glucose Intolerance - complications ; Glucose Intolerance - drug therapy ; Humans ; Insulin Resistance ; Interleukin-6 - blood ; Lipids - blood ; Malondialdehyde - blood ; Middle Aged ; Obesity - blood ; Obesity - complications ; Obesity - drug therapy ; Oxidative Stress - drug effects ; Prostaglandins - blood ; Thioctic Acid - pharmacology ; Thioctic Acid - therapeutic use ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Obesity (Silver Spring, Md.), 2011-08, Vol.19 (8), p.1647-1653</ispartof><rights>2011 North American Association for the Study of Obesity (NAASO)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3705-b83f7ca16e3aad8ec4c9fe96df895a935a08083beb203135e27c04828f6ff8c53</citedby><cites>FETCH-LOGICAL-c3705-b83f7ca16e3aad8ec4c9fe96df895a935a08083beb203135e27c04828f6ff8c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2011.121$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2011.121$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21593803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yongyan</creatorcontrib><creatorcontrib>Han, Ping</creatorcontrib><creatorcontrib>Wu, Na</creatorcontrib><creatorcontrib>He, Bing</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Li, Shuwen</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Zhao, Sheng</creatorcontrib><creatorcontrib>Liu, Letong</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><title>Amelioration of Lipid Abnormalities by α‐Lipoic acid Through Antioxidative and Anti‐Inflammatory Effects</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin‐resistant states of obesity and type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia. α‐Lipoic acid (ALA) is a potent antioxidant with insulin sensitizing activity. However, it is not clear whether ALA is effective on lipid parameters in humans. This study has investigated 22 obese subjects with IGT (obese‐IGT), 13 of whom underwent 2‐week ALA treatment, 600 mg intravenously once daily. Before and after the treatment, euglycemic‐hyperinsulinemic clamps were used to measure insulin sensitivity. Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers were measured. After treatment of ALA in obese‐IGT patients, insulin sensitivity was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T‐Chol), low density lipoprotein‐cholesterol (LDL‐Chol), small dense LDL‐Chol (sd‐LDL), oxidized LDL‐Chol (ox‐LDL‐Chol), very low density lipoprotein‐cholesterol (VLDL‐Chol) were all significantly decreased (P < 0.01). At the same time, both plasma oxidative products (malondialdehyde (MDA), 8‐iso‐prostaglandin) and inflammatory markers (tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6)) were remarkably decreased (P < 0.01), while adiponectin was increased (P < 0.01). There are significant negative correlations between ISI and plasma FFAs, sd‐LDL‐Chol, ox‐LDL‐Chol, MDA, 8‐iso‐prostaglandin, TNF‐α, and IL‐6, and positive correlations with HDL‐Chol and adiponectin in obese‐IGT patients. The results indicate that short‐term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biomarkers - blood</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Intolerance - complications</subject><subject>Glucose Intolerance - drug therapy</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Interleukin-6 - blood</subject><subject>Lipids - blood</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - drug therapy</subject><subject>Oxidative Stress - drug effects</subject><subject>Prostaglandins - blood</subject><subject>Thioctic Acid - pharmacology</subject><subject>Thioctic Acid - therapeutic use</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1OwzAYQC0EoqWwMSNvLLT4p27ssVQFKlViAQkmy3FsMEriYqdANo7AVbgIh-AkGFo6MvmTv_e94QFwiNEAI8pPfd4OCMJ4gAneAl0sKOpnVNxub2aOO2AvxkeEhiPE8C7oEMwE5Yh2QTWuTOl8UI3zNfQWzt3CFXCc1z5UqnSNMxHmLfz8-Hp7TzvvNFQ6EdcPwS_vH-C4TpevrkiCZwNVXfz-JHhW21JVlWp8aOHUWqObuA92rCqjOVi_PXBzPr2eXPbnVxezyXje1zRDrJ9zajOt8MhQpQpu9FALa8SosFwwJShTiCNOc5MTRDFlhmQaDTnhdmQt14z2wPHKuwj-aWliIysXtSlLVRu_jJJnYsipYCSRJytSBx9jMFYugqtUaCVG8qevTH3lT1-Z-ib8aC1e5pUpNvBf0ATgFfDiStP-K5NXZ3eEZIx-A3w9iaQ</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Zhang, Yongyan</creator><creator>Han, Ping</creator><creator>Wu, Na</creator><creator>He, Bing</creator><creator>Lu, Yan</creator><creator>Li, Shuwen</creator><creator>Liu, Yang</creator><creator>Zhao, Sheng</creator><creator>Liu, Letong</creator><creator>Li, Yan</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Amelioration of Lipid Abnormalities by α‐Lipoic acid Through Antioxidative and Anti‐Inflammatory Effects</title><author>Zhang, Yongyan ; Han, Ping ; Wu, Na ; He, Bing ; Lu, Yan ; Li, Shuwen ; Liu, Yang ; Zhao, Sheng ; Liu, Letong ; Li, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3705-b83f7ca16e3aad8ec4c9fe96df895a935a08083beb203135e27c04828f6ff8c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biomarkers - blood</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Intolerance - complications</topic><topic>Glucose Intolerance - drug therapy</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Interleukin-6 - blood</topic><topic>Lipids - blood</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - drug therapy</topic><topic>Oxidative Stress - drug effects</topic><topic>Prostaglandins - blood</topic><topic>Thioctic Acid - pharmacology</topic><topic>Thioctic Acid - therapeutic use</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yongyan</creatorcontrib><creatorcontrib>Han, Ping</creatorcontrib><creatorcontrib>Wu, Na</creatorcontrib><creatorcontrib>He, Bing</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Li, Shuwen</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Zhao, Sheng</creatorcontrib><creatorcontrib>Liu, Letong</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yongyan</au><au>Han, Ping</au><au>Wu, Na</au><au>He, Bing</au><au>Lu, Yan</au><au>Li, Shuwen</au><au>Liu, Yang</au><au>Zhao, Sheng</au><au>Liu, Letong</au><au>Li, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amelioration of Lipid Abnormalities by α‐Lipoic acid Through Antioxidative and Anti‐Inflammatory Effects</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2011-08</date><risdate>2011</risdate><volume>19</volume><issue>8</issue><spage>1647</spage><epage>1653</epage><pages>1647-1653</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin‐resistant states of obesity and type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia. α‐Lipoic acid (ALA) is a potent antioxidant with insulin sensitizing activity. However, it is not clear whether ALA is effective on lipid parameters in humans. This study has investigated 22 obese subjects with IGT (obese‐IGT), 13 of whom underwent 2‐week ALA treatment, 600 mg intravenously once daily. Before and after the treatment, euglycemic‐hyperinsulinemic clamps were used to measure insulin sensitivity. Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers were measured. After treatment of ALA in obese‐IGT patients, insulin sensitivity was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T‐Chol), low density lipoprotein‐cholesterol (LDL‐Chol), small dense LDL‐Chol (sd‐LDL), oxidized LDL‐Chol (ox‐LDL‐Chol), very low density lipoprotein‐cholesterol (VLDL‐Chol) were all significantly decreased (P < 0.01). At the same time, both plasma oxidative products (malondialdehyde (MDA), 8‐iso‐prostaglandin) and inflammatory markers (tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6)) were remarkably decreased (P < 0.01), while adiponectin was increased (P < 0.01). There are significant negative correlations between ISI and plasma FFAs, sd‐LDL‐Chol, ox‐LDL‐Chol, MDA, 8‐iso‐prostaglandin, TNF‐α, and IL‐6, and positive correlations with HDL‐Chol and adiponectin in obese‐IGT patients. The results indicate that short‐term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21593803</pmid><doi>10.1038/oby.2011.121</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adult Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Antioxidants - therapeutic use Biomarkers - blood Glucose Intolerance - blood Glucose Intolerance - complications Glucose Intolerance - drug therapy Humans Insulin Resistance Interleukin-6 - blood Lipids - blood Malondialdehyde - blood Middle Aged Obesity - blood Obesity - complications Obesity - drug therapy Oxidative Stress - drug effects Prostaglandins - blood Thioctic Acid - pharmacology Thioctic Acid - therapeutic use Tumor Necrosis Factor-alpha - blood |
| title | Amelioration of Lipid Abnormalities by α‐Lipoic acid Through Antioxidative and Anti‐Inflammatory Effects |
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