Xenon fails to inhibit capsaicin-evoked CGRP release by nociceptors in culture

► Xenon fails to inhibit nociceptor signalling ► Capsaicin-evoked CGRP release is not reduced by xenon ► Xenon fails to produce an analgesic effect on peripheral nociceptors. To investigate whether the xenon-induced inhibition of the transient receptor potential vanilloid type 1 (TRPV1) ion channel...

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Veröffentlicht in:	Neuroscience letters 2011-07, Vol.499 (2), p.124-126
Hauptverfasser:	Calcott, Guy, White, John P.M., Nagy, Istvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Biological and medical sciences Calcitonin Gene-Related Peptide - antagonists & inhibitors Calcitonin Gene-Related Peptide - secretion Capsaicin - antagonists & inhibitors Capsaicin - pharmacology Cells, Cultured CGRP Female Fundamental and applied biological sciences. Psychology Nociceptors Nociceptors - physiology Nociceptors - secretion Pain Rats Rats, Sprague-Dawley TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - secretion Vertebrates: nervous system and sense organs Xenon Xenon - pharmacology
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