A simple DNA gate motif for synthesizing large-scale circuits
The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to c...
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| Veröffentlicht in: | Journal of the Royal Society interface 2011-09, Vol.8 (62), p.1281-1297 |
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| container_title | Journal of the Royal Society interface |
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| creator | Qian, Lulu Winfree, Erik |
| description | The prospects of programming molecular systems to perform complex autonomous tasks have motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analogue circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates. |
| doi_str_mv | 10.1098/rsif.2010.0729 |
| format | Article |
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Here, we propose a simple DNA gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates.</description><subject>Computers, Molecular</subject><subject>DNA - chemistry</subject><subject>Molecular Programming</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleic Acids</subject><subject>Strand Displacement Circuits</subject><subject>Synthetic Biology</subject><issn>1742-5689</issn><issn>1742-5662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEUhS1ExavdskSzYzWp3x4vQIoCfUioqFUb2FkexxMMM-NgeyrSX4-jhIguEKt7r_zdo-N7ADhGcISgrD6H6JoRhnmEAssdcIAExSXjHO9u-0rug8MY7yEkgjC2B_YxwpILiQ_A2biIrlu0trj4MS7mOtmi88k1ReNDEZd9urPR_XP9vGh1mNsyGp1Z44IZXIofwYdGt9F-2tQj8OfL5e_Jt_Lq-uv3yfiqNIzLVGrB6ooaO4O1xYiYGteVMJBpDcXMGl3LqpLZDqSNhpDOGlLzmhuImEFGSEOOwPladzHUnZ0Z26egW7UIrtNhqbx26v-X3t2puf-rCKL5LiQLnG4Egn8cbEyqc9HYttW99UNUEgrEOZP8XbISkmarFGdytCZN8DEG22z9IKhW4ahVOGoVjlqFkxdOXv9ii7-kkQGyBoJf5nN642xaqns_hD6Pb8uW6y0Xk33aqurwoLgggqlpRdXNT3gjf91SNSXPqheseQ</recordid><startdate>20110907</startdate><enddate>20110907</enddate><creator>Qian, Lulu</creator><creator>Winfree, Erik</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>5PM</scope></search><sort><creationdate>20110907</creationdate><title>A simple DNA gate motif for synthesizing large-scale circuits</title><author>Qian, Lulu ; Winfree, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-a75b84ced0be213cb2b87c05aa07decab988979204fa004df3b6b6c015c1c79c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Computers, Molecular</topic><topic>DNA - chemistry</topic><topic>Molecular Programming</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleic Acids</topic><topic>Strand Displacement Circuits</topic><topic>Synthetic Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Lulu</creatorcontrib><creatorcontrib>Winfree, Erik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Royal Society interface</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Lulu</au><au>Winfree, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A simple DNA gate motif for synthesizing large-scale circuits</atitle><jtitle>Journal of the Royal Society interface</jtitle><stitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 1742-5689 |
| ispartof | Journal of the Royal Society interface, 2011-09, Vol.8 (62), p.1281-1297 |
| issn | 1742-5689 1742-5662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_879479242 |
| source | MEDLINE; PubMed Central |
| subjects | Computers, Molecular DNA - chemistry Molecular Programming Nucleic Acid Conformation Nucleic Acids Strand Displacement Circuits Synthetic Biology |
| title | A simple DNA gate motif for synthesizing large-scale circuits |
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