Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression

ABSTRACT Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene...

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Veröffentlicht in:	Journal of applied toxicology 2011-05, Vol.31 (4), p.366-377
Hauptverfasser:	Swain, Aubrey, Turton, John, Scudamore, Cheryl L., Pereira, Ines, Viswanathan, Neeti, Smyth, Rosemary, Munday, Michael, McClure, Fiona, Gandhi, Mitul, Sondh, Surjit, York, Malcolm
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - genetics Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - urine Albuminuria - chemically induced Albuminuria - genetics Albuminuria - pathology Albuminuria - urine Animals Biomarkers - urine Butadienes - toxicity Cell Adhesion Molecules - urine Female Gene Expression - drug effects Gene Expression Profiling hexachloro-1:3-butadiene Immunoassay Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Function Tests Liver - drug effects Liver - metabolism Liver - pathology Necrosis rat Rats Rats, Inbred Strains renal injury Reverse Transcriptase Polymerase Chain Reaction toxicity urinary biomarkers
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