Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression
ABSTRACT Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene...
Gespeichert in:
| Veröffentlicht in: | Journal of applied toxicology 2011-05, Vol.31 (4), p.366-377 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 377 |
|---|---|
| container_issue | 4 |
| container_start_page | 366 |
| container_title | Journal of applied toxicology |
| container_volume | 31 |
| creator | Swain, Aubrey Turton, John Scudamore, Cheryl L. Pereira, Ines Viswanathan, Neeti Smyth, Rosemary Munday, Michael McClure, Fiona Gandhi, Mitul Sondh, Surjit York, Malcolm |
| description | ABSTRACT
Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene expression. Multiplexed renal biomarker measurements were performed using both the Meso Scale Discovery (MSD) and Rules Based Medicine platforms. In a second study, rats were treated with a single nephrotoxic dose of HCBD and the time course release of a range of traditional and newer urinary biomarkers was followed over a 25 day period. Urinary albumin (a marker of both proximal tubular function and glomerular integrity) and α‐glutathione S‐transferase (α‐GST, a proximal tubular cell marker of cytoplasmic leakage) showed the largest fold change at 24 h (day 1) after dosing. Most other markers measured on either the MSD or RBM platforms peaked on day 1 or 2 post‐dosing, whereas levels of kidney injury molecule‐1 (KIM‐1), a marker of tubular regeneration, peaked on day 3/4. Therefore, in rat proximal tubular nephrotoxicity, the measurement of urinary albumin, α‐GST and KIM‐1 is recommended as they potentially provide useful information about the function, degree of damage and repair of the proximal tubule. Gene expression data provided useful confirmatory information regarding exposure of the kidney and liver to HCBD, and the response of these tissues to HCBD in terms of metabolism, oxidative stress, inflammation, and regeneration and repair. Copyright © 2011 John Wiley & Sons, Ltd.
Acute hexachloro‐1:3‐butadiene‐induced injury to the female rat nephron was characterized at 24 h post‐dosing and over 25 days. Urinary albumin and α‐glutathione S‐transferase (alpha‐GST) excretion showed the largest fold change at 24 h post‐dosing. Over 25 days, most urinary markers peaked on Day 1/2 post‐dosing, whereas kidney injury molecule‐1 (KIM‐1) levels, peaked on Day 3/4. In acute proximal tubular nephrotoxicity, the measurement of urinary albumin, alpha‐GST and KIM‐1 is recommended, giving useful information about proximal tubular function, damage, and repair. |
| doi_str_mv | 10.1002/jat.1624 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_879479055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>879479055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4244-cffe47ed7f538ceb38a5fc4cc9453d091f47d6b715bf00ce11dbedca43cf5d3c3</originalsourceid><addsrcrecordid>eNp1kcFuEzEQhlcIRNOCxBMg3-BQF3vtzWbhVCpIgQoObVVultceZ51618H20uSxeBEeg-fAIaEHJE4jzXzzjeW_KJ5RckIJKV8tZTqh05I_KCaUNA2m5ZQ9LCaknBLMWf31oDiMcUlInpWzx8VBScuqKRs2KX5dBzvIsEGt9b0MtxAisgPqYC1V53zwmL5muB2T1BYGwHbQowKNpBoToFurB9jkheUYtgWlDpCBXjpA53Lw3yGgGxuTDCjI9AYpHwI4mawfkDfo5w-8cFmdutwAdIlTkEM0EGSEYyRdO_bZKQf9z6HeO1CjA0zRnU0d6vIJv8oa7_xi82dhkR-LYL0KEGOWPykeGekiPN3Xo-L6_burs3N88WX-4ez0Aiteco6VMcBr0LWp2ExBy2ayMoor1fCKadJQw2s9bWtatYYQBZTqFrSSnClTaabYUfFi510F_22EmERvowLn5AB-jGJWN7xuSFVl8uWOVMHHGMCIVbA5gY2gRGxDFTlUsQ01o8_30rHtQd-Df1PMAN4Bd9bB5r8i8fH0ai_c8_nfYH3P5_jFtGZ1JW4-zwWdv_1UknouLtlv8rPCmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>879479055</pqid></control><display><type>article</type><title>Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Swain, Aubrey ; Turton, John ; Scudamore, Cheryl L. ; Pereira, Ines ; Viswanathan, Neeti ; Smyth, Rosemary ; Munday, Michael ; McClure, Fiona ; Gandhi, Mitul ; Sondh, Surjit ; York, Malcolm</creator><creatorcontrib>Swain, Aubrey ; Turton, John ; Scudamore, Cheryl L. ; Pereira, Ines ; Viswanathan, Neeti ; Smyth, Rosemary ; Munday, Michael ; McClure, Fiona ; Gandhi, Mitul ; Sondh, Surjit ; York, Malcolm</creatorcontrib><description>ABSTRACT
Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene expression. Multiplexed renal biomarker measurements were performed using both the Meso Scale Discovery (MSD) and Rules Based Medicine platforms. In a second study, rats were treated with a single nephrotoxic dose of HCBD and the time course release of a range of traditional and newer urinary biomarkers was followed over a 25 day period. Urinary albumin (a marker of both proximal tubular function and glomerular integrity) and α‐glutathione S‐transferase (α‐GST, a proximal tubular cell marker of cytoplasmic leakage) showed the largest fold change at 24 h (day 1) after dosing. Most other markers measured on either the MSD or RBM platforms peaked on day 1 or 2 post‐dosing, whereas levels of kidney injury molecule‐1 (KIM‐1), a marker of tubular regeneration, peaked on day 3/4. Therefore, in rat proximal tubular nephrotoxicity, the measurement of urinary albumin, α‐GST and KIM‐1 is recommended as they potentially provide useful information about the function, degree of damage and repair of the proximal tubule. Gene expression data provided useful confirmatory information regarding exposure of the kidney and liver to HCBD, and the response of these tissues to HCBD in terms of metabolism, oxidative stress, inflammation, and regeneration and repair. Copyright © 2011 John Wiley & Sons, Ltd.
Acute hexachloro‐1:3‐butadiene‐induced injury to the female rat nephron was characterized at 24 h post‐dosing and over 25 days. Urinary albumin and α‐glutathione S‐transferase (alpha‐GST) excretion showed the largest fold change at 24 h post‐dosing. Over 25 days, most urinary markers peaked on Day 1/2 post‐dosing, whereas kidney injury molecule‐1 (KIM‐1) levels, peaked on Day 3/4. In acute proximal tubular nephrotoxicity, the measurement of urinary albumin, alpha‐GST and KIM‐1 is recommended, giving useful information about proximal tubular function, damage, and repair.</description><identifier>ISSN: 0260-437X</identifier><identifier>ISSN: 1099-1263</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.1624</identifier><identifier>PMID: 21259293</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acute Kidney Injury - genetics ; Acute Kidney Injury - metabolism ; Acute Kidney Injury - pathology ; Acute Kidney Injury - urine ; Albuminuria - chemically induced ; Albuminuria - genetics ; Albuminuria - pathology ; Albuminuria - urine ; Animals ; Biomarkers - urine ; Butadienes - toxicity ; Cell Adhesion Molecules - urine ; Female ; Gene Expression - drug effects ; Gene Expression Profiling ; hexachloro-1:3-butadiene ; Immunoassay ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Function Tests ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Necrosis ; rat ; Rats ; Rats, Inbred Strains ; renal injury ; Reverse Transcriptase Polymerase Chain Reaction ; toxicity ; urinary biomarkers</subject><ispartof>Journal of applied toxicology, 2011-05, Vol.31 (4), p.366-377</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-cffe47ed7f538ceb38a5fc4cc9453d091f47d6b715bf00ce11dbedca43cf5d3c3</citedby><cites>FETCH-LOGICAL-c4244-cffe47ed7f538ceb38a5fc4cc9453d091f47d6b715bf00ce11dbedca43cf5d3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.1624$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.1624$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21259293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swain, Aubrey</creatorcontrib><creatorcontrib>Turton, John</creatorcontrib><creatorcontrib>Scudamore, Cheryl L.</creatorcontrib><creatorcontrib>Pereira, Ines</creatorcontrib><creatorcontrib>Viswanathan, Neeti</creatorcontrib><creatorcontrib>Smyth, Rosemary</creatorcontrib><creatorcontrib>Munday, Michael</creatorcontrib><creatorcontrib>McClure, Fiona</creatorcontrib><creatorcontrib>Gandhi, Mitul</creatorcontrib><creatorcontrib>Sondh, Surjit</creatorcontrib><creatorcontrib>York, Malcolm</creatorcontrib><title>Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>ABSTRACT
Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene expression. Multiplexed renal biomarker measurements were performed using both the Meso Scale Discovery (MSD) and Rules Based Medicine platforms. In a second study, rats were treated with a single nephrotoxic dose of HCBD and the time course release of a range of traditional and newer urinary biomarkers was followed over a 25 day period. Urinary albumin (a marker of both proximal tubular function and glomerular integrity) and α‐glutathione S‐transferase (α‐GST, a proximal tubular cell marker of cytoplasmic leakage) showed the largest fold change at 24 h (day 1) after dosing. Most other markers measured on either the MSD or RBM platforms peaked on day 1 or 2 post‐dosing, whereas levels of kidney injury molecule‐1 (KIM‐1), a marker of tubular regeneration, peaked on day 3/4. Therefore, in rat proximal tubular nephrotoxicity, the measurement of urinary albumin, α‐GST and KIM‐1 is recommended as they potentially provide useful information about the function, degree of damage and repair of the proximal tubule. Gene expression data provided useful confirmatory information regarding exposure of the kidney and liver to HCBD, and the response of these tissues to HCBD in terms of metabolism, oxidative stress, inflammation, and regeneration and repair. Copyright © 2011 John Wiley & Sons, Ltd.
Acute hexachloro‐1:3‐butadiene‐induced injury to the female rat nephron was characterized at 24 h post‐dosing and over 25 days. Urinary albumin and α‐glutathione S‐transferase (alpha‐GST) excretion showed the largest fold change at 24 h post‐dosing. Over 25 days, most urinary markers peaked on Day 1/2 post‐dosing, whereas kidney injury molecule‐1 (KIM‐1) levels, peaked on Day 3/4. In acute proximal tubular nephrotoxicity, the measurement of urinary albumin, alpha‐GST and KIM‐1 is recommended, giving useful information about proximal tubular function, damage, and repair.</description><subject>Acute Kidney Injury - genetics</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - urine</subject><subject>Albuminuria - chemically induced</subject><subject>Albuminuria - genetics</subject><subject>Albuminuria - pathology</subject><subject>Albuminuria - urine</subject><subject>Animals</subject><subject>Biomarkers - urine</subject><subject>Butadienes - toxicity</subject><subject>Cell Adhesion Molecules - urine</subject><subject>Female</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression Profiling</subject><subject>hexachloro-1:3-butadiene</subject><subject>Immunoassay</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Function Tests</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Necrosis</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>renal injury</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>toxicity</subject><subject>urinary biomarkers</subject><issn>0260-437X</issn><issn>1099-1263</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuEzEQhlcIRNOCxBMg3-BQF3vtzWbhVCpIgQoObVVultceZ51618H20uSxeBEeg-fAIaEHJE4jzXzzjeW_KJ5RckIJKV8tZTqh05I_KCaUNA2m5ZQ9LCaknBLMWf31oDiMcUlInpWzx8VBScuqKRs2KX5dBzvIsEGt9b0MtxAisgPqYC1V53zwmL5muB2T1BYGwHbQowKNpBoToFurB9jkheUYtgWlDpCBXjpA53Lw3yGgGxuTDCjI9AYpHwI4mawfkDfo5w-8cFmdutwAdIlTkEM0EGSEYyRdO_bZKQf9z6HeO1CjA0zRnU0d6vIJv8oa7_xi82dhkR-LYL0KEGOWPykeGekiPN3Xo-L6_burs3N88WX-4ez0Aiteco6VMcBr0LWp2ExBy2ayMoor1fCKadJQw2s9bWtatYYQBZTqFrSSnClTaabYUfFi510F_22EmERvowLn5AB-jGJWN7xuSFVl8uWOVMHHGMCIVbA5gY2gRGxDFTlUsQ01o8_30rHtQd-Df1PMAN4Bd9bB5r8i8fH0ai_c8_nfYH3P5_jFtGZ1JW4-zwWdv_1UknouLtlv8rPCmw</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Swain, Aubrey</creator><creator>Turton, John</creator><creator>Scudamore, Cheryl L.</creator><creator>Pereira, Ines</creator><creator>Viswanathan, Neeti</creator><creator>Smyth, Rosemary</creator><creator>Munday, Michael</creator><creator>McClure, Fiona</creator><creator>Gandhi, Mitul</creator><creator>Sondh, Surjit</creator><creator>York, Malcolm</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201105</creationdate><title>Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression</title><author>Swain, Aubrey ; Turton, John ; Scudamore, Cheryl L. ; Pereira, Ines ; Viswanathan, Neeti ; Smyth, Rosemary ; Munday, Michael ; McClure, Fiona ; Gandhi, Mitul ; Sondh, Surjit ; York, Malcolm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4244-cffe47ed7f538ceb38a5fc4cc9453d091f47d6b715bf00ce11dbedca43cf5d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Kidney Injury - genetics</topic><topic>Acute Kidney Injury - metabolism</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute Kidney Injury - urine</topic><topic>Albuminuria - chemically induced</topic><topic>Albuminuria - genetics</topic><topic>Albuminuria - pathology</topic><topic>Albuminuria - urine</topic><topic>Animals</topic><topic>Biomarkers - urine</topic><topic>Butadienes - toxicity</topic><topic>Cell Adhesion Molecules - urine</topic><topic>Female</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression Profiling</topic><topic>hexachloro-1:3-butadiene</topic><topic>Immunoassay</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Function Tests</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Necrosis</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>renal injury</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>toxicity</topic><topic>urinary biomarkers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swain, Aubrey</creatorcontrib><creatorcontrib>Turton, John</creatorcontrib><creatorcontrib>Scudamore, Cheryl L.</creatorcontrib><creatorcontrib>Pereira, Ines</creatorcontrib><creatorcontrib>Viswanathan, Neeti</creatorcontrib><creatorcontrib>Smyth, Rosemary</creatorcontrib><creatorcontrib>Munday, Michael</creatorcontrib><creatorcontrib>McClure, Fiona</creatorcontrib><creatorcontrib>Gandhi, Mitul</creatorcontrib><creatorcontrib>Sondh, Surjit</creatorcontrib><creatorcontrib>York, Malcolm</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swain, Aubrey</au><au>Turton, John</au><au>Scudamore, Cheryl L.</au><au>Pereira, Ines</au><au>Viswanathan, Neeti</au><au>Smyth, Rosemary</au><au>Munday, Michael</au><au>McClure, Fiona</au><au>Gandhi, Mitul</au><au>Sondh, Surjit</au><au>York, Malcolm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>2011-05</date><risdate>2011</risdate><volume>31</volume><issue>4</issue><spage>366</spage><epage>377</epage><pages>366-377</pages><issn>0260-437X</issn><issn>1099-1263</issn><eissn>1099-1263</eissn><abstract>ABSTRACT
Hexachloro‐1:3‐butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene expression. Multiplexed renal biomarker measurements were performed using both the Meso Scale Discovery (MSD) and Rules Based Medicine platforms. In a second study, rats were treated with a single nephrotoxic dose of HCBD and the time course release of a range of traditional and newer urinary biomarkers was followed over a 25 day period. Urinary albumin (a marker of both proximal tubular function and glomerular integrity) and α‐glutathione S‐transferase (α‐GST, a proximal tubular cell marker of cytoplasmic leakage) showed the largest fold change at 24 h (day 1) after dosing. Most other markers measured on either the MSD or RBM platforms peaked on day 1 or 2 post‐dosing, whereas levels of kidney injury molecule‐1 (KIM‐1), a marker of tubular regeneration, peaked on day 3/4. Therefore, in rat proximal tubular nephrotoxicity, the measurement of urinary albumin, α‐GST and KIM‐1 is recommended as they potentially provide useful information about the function, degree of damage and repair of the proximal tubule. Gene expression data provided useful confirmatory information regarding exposure of the kidney and liver to HCBD, and the response of these tissues to HCBD in terms of metabolism, oxidative stress, inflammation, and regeneration and repair. Copyright © 2011 John Wiley & Sons, Ltd.
Acute hexachloro‐1:3‐butadiene‐induced injury to the female rat nephron was characterized at 24 h post‐dosing and over 25 days. Urinary albumin and α‐glutathione S‐transferase (alpha‐GST) excretion showed the largest fold change at 24 h post‐dosing. Over 25 days, most urinary markers peaked on Day 1/2 post‐dosing, whereas kidney injury molecule‐1 (KIM‐1) levels, peaked on Day 3/4. In acute proximal tubular nephrotoxicity, the measurement of urinary albumin, alpha‐GST and KIM‐1 is recommended, giving useful information about proximal tubular function, damage, and repair.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21259293</pmid><doi>10.1002/jat.1624</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0260-437X |
| ispartof | Journal of applied toxicology, 2011-05, Vol.31 (4), p.366-377 |
| issn | 0260-437X 1099-1263 1099-1263 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_879479055 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acute Kidney Injury - genetics Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - urine Albuminuria - chemically induced Albuminuria - genetics Albuminuria - pathology Albuminuria - urine Animals Biomarkers - urine Butadienes - toxicity Cell Adhesion Molecules - urine Female Gene Expression - drug effects Gene Expression Profiling hexachloro-1:3-butadiene Immunoassay Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Function Tests Liver - drug effects Liver - metabolism Liver - pathology Necrosis rat Rats Rats, Inbred Strains renal injury Reverse Transcriptase Polymerase Chain Reaction toxicity urinary biomarkers |
| title | Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A33%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Urinary%20biomarkers%20in%20hexachloro-1:3-butadiene-induced%20acute%20kidney%20injury%20in%20the%20female%20Hanover%20Wistar%20rat;%20correlation%20of%20%CE%B1-glutathione%20S-transferase,%20albumin%20and%20kidney%20injury%20molecule-1%20with%20histopathology%20and%20gene%20expression&rft.jtitle=Journal%20of%20applied%20toxicology&rft.au=Swain,%20Aubrey&rft.date=2011-05&rft.volume=31&rft.issue=4&rft.spage=366&rft.epage=377&rft.pages=366-377&rft.issn=0260-437X&rft.eissn=1099-1263&rft_id=info:doi/10.1002/jat.1624&rft_dat=%3Cproquest_cross%3E879479055%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=879479055&rft_id=info:pmid/21259293&rfr_iscdi=true |