Sequential measurements of glomerular filtration rate in conscious rats by a bolus injection of iodixanol and a single blood sample

ABSTRACT To estimate the glomerular filtration rate (GFR) sequentially in conscious rats, we validated a single‐blood‐sample method using a bolus injection of the nonionic contrast medium iodixanol as a tracer. First, to clarify basal age‐related GFR profiles, iodixanol was intravenously administere...

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Veröffentlicht in:	Journal of applied toxicology 2011-05, Vol.31 (4), p.360-365
Hauptverfasser:	Katayama, Rieko, Watanabe, Kanji, Yamagishi, Norio, Abe, Sumito, Satoh, Hiroshi, Furuhama, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - blood Animal Use Alternatives Animals Biological and medical sciences Chromatography, High Pressure Liquid Contrast Media contrast medium Glomerular Filtration Rate HPLC Injections, Intravenous Kidney Diseases - blood Kidney Diseases - chemically induced Male Medical sciences nephropathy rat Rats Rats, Inbred F344 Toxicology Triiodobenzoic Acids - blood
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