Dishevelled2 Is a Stable Protein During Early Zebrafish Development
Wnt signaling is a major player during development and its misregulation often leads to disease, especially cancer. The negative feedback Wnt regulator homologs, Nkd1 and Nkd2, have been shown to inhibit Wnt signaling during development, and current evidence suggests that Nkds degrade Dvl proteins t...
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| Veröffentlicht in: | Zebrafish 2011-06, Vol.8 (2), p.65-71 |
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| creator | Lum, Whitney M. Robertson, Joshua K. Van Raay, Terence J. |
| description | Wnt signaling is a major player during development and its misregulation often leads to disease, especially cancer. The negative feedback Wnt regulator homologs, Nkd1 and Nkd2, have been shown to inhibit Wnt signaling during development, and current evidence suggests that Nkds degrade Dvl proteins to antagonize Wnt signaling. Here, we demonstrate that during early zebrafish development Nkd1 does not alter either endogenous or exogenous levels of Dvl2. Furthermore, Dvl2 does not affect the levels of Nkd1. Cumulatively, these results demonstrate that Dvl2 is a ubiquitous and stable protein and that Nkds may not always function to degrade Dvl proteins as a method of inhibiting Wnt signaling. |
| doi_str_mv | 10.1089/zeb.2011.0691 |
| format | Article |
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| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cellular signal transduction Danio rerio Dishevelled Proteins Embryonic development Freshwater Gene Expression Regulation, Developmental Genetic aspects Growth Humans Molecular Sequence Data Original Articles Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Proteasome Endopeptidase Complex - metabolism Proteolysis Sequence Alignment Signal Transduction Zebra fish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| title | Dishevelled2 Is a Stable Protein During Early Zebrafish Development |
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