Deficit of sensorimotor integration in normal aging
► In this study we explored age-related changes in sensorimotor integration. ► We assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked inhibition or facilitation. ► We observed a marked decrease of the long latency influence of proprioceptive inpu...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 2011-07, Vol.498 (3), p.208-212 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 212 |
|---|---|
| container_issue | 3 |
| container_start_page | 208 |
| container_title | Neuroscience letters |
| container_volume | 498 |
| creator | Degardin, Adrian Devos, David Cassim, François Bourriez, Jean-Louis Defebvre, Luc Derambure, Philippe Devanne, Hervé |
| description | ► In this study we explored age-related changes in sensorimotor integration. ► We assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked inhibition or facilitation. ► We observed a marked decrease of the long latency influence of proprioceptive inputs on primary motor cortex excitability in the elderly. ► We found no change of intracortical inhibition and facilitation within the primary motor cortex. ► We conclude that decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs.
Sensorimotor performance declines with normal aging. The present study explored age-related changes in sensorimotor integration by conditioning a supra-threshold transcranial magnetic stimulation pulse with a peripheral nerve shock at different interstimulus intervals. Cortical motor threshold of the
abductor pollicis brevis muscle, intracortical inhibition and facilitation were measured. We also assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked short- and long-latency afferent inhibition (SAI and LAI, respectively) and afferent-induced facilitation (AIF). We observed a marked decrease of the long latency influence of proprioceptive inputs on M1 excitability in the elderly, with the loss of AIF and LAI. The SAI, motor thresholds and intracortical inhibition and facilitation were not age-related. Decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs on motor cortex excitability at longer intervals (probably via higher order cortical areas). |
| doi_str_mv | 10.1016/j.neulet.2011.05.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_879478953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304394011006008</els_id><sourcerecordid>873315422</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-fb5f591a94d917a360d9fb957cc7bd75b62cbb72fae8bf7860bbc68d52421dff3</originalsourceid><addsrcrecordid>eNqNkE1P3DAQhq0KVLa0_6BCuaCeEsaOHceXSoh-gITEhZ4t2xmvvMra1M4i8e9rtEu5IU4zh-edj4eQrxQ6CnS42HQRdzMuHQNKOxAdUPhAVnSUrJVKsiOygh542ysOJ-RTKRsAEFTwj-SE0QFAiXFF-h_ogwtLk3xTMJaUwzYtKTchLrjOZgkp1r6JKW_N3Jh1iOvP5NibueCXQz0lf379vL-6bm_vft9cXd62jo9qab0VXihqFJ8UlaYfYFLeKiGdk3aSwg7MWSuZNzhaL8cBrHXDOAnGGZ2870_Jt_3ch5z-7rAsehuKw3k2EdOu6FEqLkcl-neQfV8_Z6ySfE-6nErJ6PVD_djkJ01BP3vVG733qp-9ahC6eq2xs8OCnd3i9D_0IrIC5wfAFGdmn010obxynCklJa_c9z2HVdxjwKyLCxgdTiGjW_SUwtuX_AN8d5fi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873315422</pqid></control><display><type>article</type><title>Deficit of sensorimotor integration in normal aging</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Degardin, Adrian ; Devos, David ; Cassim, François ; Bourriez, Jean-Louis ; Defebvre, Luc ; Derambure, Philippe ; Devanne, Hervé</creator><creatorcontrib>Degardin, Adrian ; Devos, David ; Cassim, François ; Bourriez, Jean-Louis ; Defebvre, Luc ; Derambure, Philippe ; Devanne, Hervé</creatorcontrib><description>► In this study we explored age-related changes in sensorimotor integration. ► We assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked inhibition or facilitation. ► We observed a marked decrease of the long latency influence of proprioceptive inputs on primary motor cortex excitability in the elderly. ► We found no change of intracortical inhibition and facilitation within the primary motor cortex. ► We conclude that decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs.
Sensorimotor performance declines with normal aging. The present study explored age-related changes in sensorimotor integration by conditioning a supra-threshold transcranial magnetic stimulation pulse with a peripheral nerve shock at different interstimulus intervals. Cortical motor threshold of the
abductor pollicis brevis muscle, intracortical inhibition and facilitation were measured. We also assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked short- and long-latency afferent inhibition (SAI and LAI, respectively) and afferent-induced facilitation (AIF). We observed a marked decrease of the long latency influence of proprioceptive inputs on M1 excitability in the elderly, with the loss of AIF and LAI. The SAI, motor thresholds and intracortical inhibition and facilitation were not age-related. Decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs on motor cortex excitability at longer intervals (probably via higher order cortical areas).</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2011.05.010</identifier><identifier>PMID: 21600958</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Afferent Pathways - physiology ; Age ; Aged ; Aging - physiology ; Biological and medical sciences ; Electric Stimulation ; Electromyography - methods ; Evoked Potentials, Motor - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Median Nerve - physiology ; Middle Aged ; Motor Cortex - physiology ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Neural Inhibition - physiology ; Normal aging ; Sensorimotor integration ; Somatosensory Disorders - physiopathology ; Thumb - innervation ; Thumb - physiology ; Time Factors ; Transcranial magnetic stimulation ; Transcranial Magnetic Stimulation - methods ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2011-07, Vol.498 (3), p.208-212</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-fb5f591a94d917a360d9fb957cc7bd75b62cbb72fae8bf7860bbc68d52421dff3</citedby><cites>FETCH-LOGICAL-c489t-fb5f591a94d917a360d9fb957cc7bd75b62cbb72fae8bf7860bbc68d52421dff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394011006008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24299774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21600958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Degardin, Adrian</creatorcontrib><creatorcontrib>Devos, David</creatorcontrib><creatorcontrib>Cassim, François</creatorcontrib><creatorcontrib>Bourriez, Jean-Louis</creatorcontrib><creatorcontrib>Defebvre, Luc</creatorcontrib><creatorcontrib>Derambure, Philippe</creatorcontrib><creatorcontrib>Devanne, Hervé</creatorcontrib><title>Deficit of sensorimotor integration in normal aging</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>► In this study we explored age-related changes in sensorimotor integration. ► We assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked inhibition or facilitation. ► We observed a marked decrease of the long latency influence of proprioceptive inputs on primary motor cortex excitability in the elderly. ► We found no change of intracortical inhibition and facilitation within the primary motor cortex. ► We conclude that decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs.
Sensorimotor performance declines with normal aging. The present study explored age-related changes in sensorimotor integration by conditioning a supra-threshold transcranial magnetic stimulation pulse with a peripheral nerve shock at different interstimulus intervals. Cortical motor threshold of the
abductor pollicis brevis muscle, intracortical inhibition and facilitation were measured. We also assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked short- and long-latency afferent inhibition (SAI and LAI, respectively) and afferent-induced facilitation (AIF). We observed a marked decrease of the long latency influence of proprioceptive inputs on M1 excitability in the elderly, with the loss of AIF and LAI. The SAI, motor thresholds and intracortical inhibition and facilitation were not age-related. Decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs on motor cortex excitability at longer intervals (probably via higher order cortical areas).</description><subject>Adult</subject><subject>Afferent Pathways - physiology</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Electromyography - methods</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Median Nerve - physiology</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Neural Inhibition - physiology</subject><subject>Normal aging</subject><subject>Sensorimotor integration</subject><subject>Somatosensory Disorders - physiopathology</subject><subject>Thumb - innervation</subject><subject>Thumb - physiology</subject><subject>Time Factors</subject><subject>Transcranial magnetic stimulation</subject><subject>Transcranial Magnetic Stimulation - methods</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq0KVLa0_6BCuaCeEsaOHceXSoh-gITEhZ4t2xmvvMra1M4i8e9rtEu5IU4zh-edj4eQrxQ6CnS42HQRdzMuHQNKOxAdUPhAVnSUrJVKsiOygh542ysOJ-RTKRsAEFTwj-SE0QFAiXFF-h_ogwtLk3xTMJaUwzYtKTchLrjOZgkp1r6JKW_N3Jh1iOvP5NibueCXQz0lf379vL-6bm_vft9cXd62jo9qab0VXihqFJ8UlaYfYFLeKiGdk3aSwg7MWSuZNzhaL8cBrHXDOAnGGZ2870_Jt_3ch5z-7rAsehuKw3k2EdOu6FEqLkcl-neQfV8_Z6ySfE-6nErJ6PVD_djkJ01BP3vVG733qp-9ahC6eq2xs8OCnd3i9D_0IrIC5wfAFGdmn010obxynCklJa_c9z2HVdxjwKyLCxgdTiGjW_SUwtuX_AN8d5fi</recordid><startdate>20110712</startdate><enddate>20110712</enddate><creator>Degardin, Adrian</creator><creator>Devos, David</creator><creator>Cassim, François</creator><creator>Bourriez, Jean-Louis</creator><creator>Defebvre, Luc</creator><creator>Derambure, Philippe</creator><creator>Devanne, Hervé</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110712</creationdate><title>Deficit of sensorimotor integration in normal aging</title><author>Degardin, Adrian ; Devos, David ; Cassim, François ; Bourriez, Jean-Louis ; Defebvre, Luc ; Derambure, Philippe ; Devanne, Hervé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-fb5f591a94d917a360d9fb957cc7bd75b62cbb72fae8bf7860bbc68d52421dff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Afferent Pathways - physiology</topic><topic>Age</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Electromyography - methods</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Median Nerve - physiology</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiology</topic><topic>Neural Inhibition - physiology</topic><topic>Normal aging</topic><topic>Sensorimotor integration</topic><topic>Somatosensory Disorders - physiopathology</topic><topic>Thumb - innervation</topic><topic>Thumb - physiology</topic><topic>Time Factors</topic><topic>Transcranial magnetic stimulation</topic><topic>Transcranial Magnetic Stimulation - methods</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Degardin, Adrian</creatorcontrib><creatorcontrib>Devos, David</creatorcontrib><creatorcontrib>Cassim, François</creatorcontrib><creatorcontrib>Bourriez, Jean-Louis</creatorcontrib><creatorcontrib>Defebvre, Luc</creatorcontrib><creatorcontrib>Derambure, Philippe</creatorcontrib><creatorcontrib>Devanne, Hervé</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Degardin, Adrian</au><au>Devos, David</au><au>Cassim, François</au><au>Bourriez, Jean-Louis</au><au>Defebvre, Luc</au><au>Derambure, Philippe</au><au>Devanne, Hervé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficit of sensorimotor integration in normal aging</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2011-07-12</date><risdate>2011</risdate><volume>498</volume><issue>3</issue><spage>208</spage><epage>212</epage><pages>208-212</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>► In this study we explored age-related changes in sensorimotor integration. ► We assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked inhibition or facilitation. ► We observed a marked decrease of the long latency influence of proprioceptive inputs on primary motor cortex excitability in the elderly. ► We found no change of intracortical inhibition and facilitation within the primary motor cortex. ► We conclude that decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs.
Sensorimotor performance declines with normal aging. The present study explored age-related changes in sensorimotor integration by conditioning a supra-threshold transcranial magnetic stimulation pulse with a peripheral nerve shock at different interstimulus intervals. Cortical motor threshold of the
abductor pollicis brevis muscle, intracortical inhibition and facilitation were measured. We also assessed the influence of median nerve stimulation on motor cortex excitability at intervals which evoked short- and long-latency afferent inhibition (SAI and LAI, respectively) and afferent-induced facilitation (AIF). We observed a marked decrease of the long latency influence of proprioceptive inputs on M1 excitability in the elderly, with the loss of AIF and LAI. The SAI, motor thresholds and intracortical inhibition and facilitation were not age-related. Decreased sensorimotor performance with aging appears to be associated with a decrease in the influence of proprioceptive inputs on motor cortex excitability at longer intervals (probably via higher order cortical areas).</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21600958</pmid><doi>10.1016/j.neulet.2011.05.010</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2011-07, Vol.498 (3), p.208-212 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_879478953 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Afferent Pathways - physiology Age Aged Aging - physiology Biological and medical sciences Electric Stimulation Electromyography - methods Evoked Potentials, Motor - physiology Female Fundamental and applied biological sciences. Psychology Humans Male Median Nerve - physiology Middle Aged Motor Cortex - physiology Muscle, Skeletal - innervation Muscle, Skeletal - physiology Neural Inhibition - physiology Normal aging Sensorimotor integration Somatosensory Disorders - physiopathology Thumb - innervation Thumb - physiology Time Factors Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Vertebrates: nervous system and sense organs |
| title | Deficit of sensorimotor integration in normal aging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T12%3A53%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deficit%20of%20sensorimotor%20integration%20in%20normal%20aging&rft.jtitle=Neuroscience%20letters&rft.au=Degardin,%20Adrian&rft.date=2011-07-12&rft.volume=498&rft.issue=3&rft.spage=208&rft.epage=212&rft.pages=208-212&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/j.neulet.2011.05.010&rft_dat=%3Cproquest_cross%3E873315422%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=873315422&rft_id=info:pmid/21600958&rft_els_id=S0304394011006008&rfr_iscdi=true |