Intracranial hemorrhage: Clinical and demographic features of patients with late hemorrhagic disease
Background: This retrospective study presents clinical, demographical features and radiological findings as well as outcomes of 31 infants with intracranial hemorrhage (ICH) due to vitamin K deficiency and hence evaluates the risk factors involved. Methods: Thirty‐one cases (17 males and 14 female...
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| Veröffentlicht in: | Pediatrics international 2011-02, Vol.53 (1), p.68-71 |
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| description | Background: This retrospective study presents clinical, demographical features and radiological findings as well as outcomes of 31 infants with intracranial hemorrhage (ICH) due to vitamin K deficiency and hence evaluates the risk factors involved.
Methods: Thirty‐one cases (17 males and 14 females) having a mean age of 52.52 ± 20.80 days with intracranial hemorrhage due to late hemorrhagic disease of the newborn (LHDN), hospitalized in our clinics were included in the study. Cranial computerized tomography (CT) was performed in all patients for the diagnosis and evaluation of ICH.
Results: It was found that the most frequent presenting symptoms were pallor (77.4%), seizures (58%), altered consciousness (58%), vomiting (44%) and poor feeding (35%). Pulsatile fontanel was found in 61% and bulging in 26%. Seven (22.5%) patients had prior history of antibiotic usage. All patients (93.5%) except two were breast fed. Sixteen (51.6%) were delivered at home. Eighteen (58%) had a history of single‐dose vitamin K prophylaxis on the first day of delivery. Parenchymal (44%), subdural (39%) or subarachnoidal (22.5%) bleeding was observed. Seven (22.6%) were exitus. During the follow‐up period (ranging from 3 months to 18 months) neurological examination findings were recorded.
Conclusion: Our results indicate that it may be questionable whether single‐dose vitamin K prophlaxis at birth is adequate for the prevention of LHDN and if a different timing of this prophylaxis should be made for the exclusively breast fed infants. |
| doi_str_mv | 10.1111/j.1442-200X.2010.03199.x |
| format | Article |
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Methods: Thirty‐one cases (17 males and 14 females) having a mean age of 52.52 ± 20.80 days with intracranial hemorrhage due to late hemorrhagic disease of the newborn (LHDN), hospitalized in our clinics were included in the study. Cranial computerized tomography (CT) was performed in all patients for the diagnosis and evaluation of ICH.
Results: It was found that the most frequent presenting symptoms were pallor (77.4%), seizures (58%), altered consciousness (58%), vomiting (44%) and poor feeding (35%). Pulsatile fontanel was found in 61% and bulging in 26%. Seven (22.5%) patients had prior history of antibiotic usage. All patients (93.5%) except two were breast fed. Sixteen (51.6%) were delivered at home. Eighteen (58%) had a history of single‐dose vitamin K prophylaxis on the first day of delivery. Parenchymal (44%), subdural (39%) or subarachnoidal (22.5%) bleeding was observed. Seven (22.6%) were exitus. During the follow‐up period (ranging from 3 months to 18 months) neurological examination findings were recorded.
Conclusion: Our results indicate that it may be questionable whether single‐dose vitamin K prophlaxis at birth is adequate for the prevention of LHDN and if a different timing of this prophylaxis should be made for the exclusively breast fed infants.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200X.2010.03199.x</identifier><identifier>PMID: 20626632</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Age ; Antibiotics ; Babies ; Bleeding ; Brain ; Breast milk ; Computed tomography ; Consciousness ; Demography ; Feeding ; Female ; Hemorrhage ; Hemorrhagic disease ; Historical account ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infants ; intracranial hemorrhage ; Intracranial Hemorrhages - diagnosis ; Intracranial Hemorrhages - etiology ; Intracranial Hemorrhages - prevention & control ; Male ; Neonates ; newborn ; Nutrient deficiency ; prevention ; Prophylaxis ; Retrospective Studies ; Risk Factors ; Seizures ; Skull ; Tomography ; Tomography, X-Ray Computed ; Turkey ; Vitamin deficiency ; Vitamin K ; Vitamin K - therapeutic use ; vitamin k deficiency ; Vitamin K Deficiency Bleeding - diagnosis ; Vitamin K Deficiency Bleeding - prevention & control ; vitamins ; Vitamins - therapeutic use ; Vomiting</subject><ispartof>Pediatrics international, 2011-02, Vol.53 (1), p.68-71</ispartof><rights>2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society</rights><rights>2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5689-59ac7123386bfb954cf64123c1cf4798ad908635e258fe5bac33cb537becc2273</citedby><cites>FETCH-LOGICAL-c5689-59ac7123386bfb954cf64123c1cf4798ad908635e258fe5bac33cb537becc2273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-200X.2010.03199.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-200X.2010.03199.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20626632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pirinccioglu, Ayfer Gözü</creatorcontrib><creatorcontrib>Gurkan, Fuat</creatorcontrib><creatorcontrib>Bosnak, Mehmet</creatorcontrib><creatorcontrib>Acemoglu, Hamit</creatorcontrib><creatorcontrib>Davutoglu, Mehmet</creatorcontrib><title>Intracranial hemorrhage: Clinical and demographic features of patients with late hemorrhagic disease</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background: This retrospective study presents clinical, demographical features and radiological findings as well as outcomes of 31 infants with intracranial hemorrhage (ICH) due to vitamin K deficiency and hence evaluates the risk factors involved.
Methods: Thirty‐one cases (17 males and 14 females) having a mean age of 52.52 ± 20.80 days with intracranial hemorrhage due to late hemorrhagic disease of the newborn (LHDN), hospitalized in our clinics were included in the study. Cranial computerized tomography (CT) was performed in all patients for the diagnosis and evaluation of ICH.
Results: It was found that the most frequent presenting symptoms were pallor (77.4%), seizures (58%), altered consciousness (58%), vomiting (44%) and poor feeding (35%). Pulsatile fontanel was found in 61% and bulging in 26%. Seven (22.5%) patients had prior history of antibiotic usage. All patients (93.5%) except two were breast fed. Sixteen (51.6%) were delivered at home. Eighteen (58%) had a history of single‐dose vitamin K prophylaxis on the first day of delivery. Parenchymal (44%), subdural (39%) or subarachnoidal (22.5%) bleeding was observed. Seven (22.6%) were exitus. During the follow‐up period (ranging from 3 months to 18 months) neurological examination findings were recorded.
Conclusion: Our results indicate that it may be questionable whether single‐dose vitamin K prophlaxis at birth is adequate for the prevention of LHDN and if a different timing of this prophylaxis should be made for the exclusively breast fed infants.</description><subject>Age</subject><subject>Antibiotics</subject><subject>Babies</subject><subject>Bleeding</subject><subject>Brain</subject><subject>Breast milk</subject><subject>Computed tomography</subject><subject>Consciousness</subject><subject>Demography</subject><subject>Feeding</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Hemorrhagic disease</subject><subject>Historical account</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>intracranial hemorrhage</subject><subject>Intracranial Hemorrhages - diagnosis</subject><subject>Intracranial Hemorrhages - etiology</subject><subject>Intracranial Hemorrhages - prevention & control</subject><subject>Male</subject><subject>Neonates</subject><subject>newborn</subject><subject>Nutrient deficiency</subject><subject>prevention</subject><subject>Prophylaxis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Seizures</subject><subject>Skull</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Turkey</subject><subject>Vitamin deficiency</subject><subject>Vitamin K</subject><subject>Vitamin K - therapeutic use</subject><subject>vitamin k deficiency</subject><subject>Vitamin K Deficiency Bleeding - diagnosis</subject><subject>Vitamin K Deficiency Bleeding - prevention & control</subject><subject>vitamins</subject><subject>Vitamins - therapeutic use</subject><subject>Vomiting</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EoqX0LyCrF05ZHH8biQMsbalUAYd-qRfLcSZdb7PJYifq9t_jsGWRuMBcZjzzvK9kvQjhkszKXO-Ws5JzWlBCbmaU5C1hpTGzzTO0vzs8zzOjutBEqj30KqUlIUQrzV-iPUoklZLRfVSfdUN0ProuuBYvYNXHuHB38B7P29AFn5euq3GdD3fRrRfB4wbcMEZIuG_w2g0BuiHhhzAscOsG-OOR0TokcAleoxeNaxMcPvUDdHlyfDH_Upx_Oz2bfzwvvJDaFMI4r0rKmJZVUxnBfSN5fvvSN1wZ7WpDtGQCqNANiMp5xnwlmKrAe0oVO0Bvt77r2P8YIQ12FZKHtnUd9GOyWhmupFH836RgUikpdCaP_iKX_Ri7_I0JorLkhmVIbyEf-5QiNHYdw8rFR1sSOyVml3YKxk7B2Ckx-ysxu8nSN0_-Y7WCeif8HVEGPmyBh9DC438b2-_Hn6cp64utPqQBNju9i_dWKqaEvf56am_1p6sTfsEtYz8BYICz6w</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Pirinccioglu, Ayfer Gözü</creator><creator>Gurkan, Fuat</creator><creator>Bosnak, Mehmet</creator><creator>Acemoglu, Hamit</creator><creator>Davutoglu, Mehmet</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201102</creationdate><title>Intracranial hemorrhage: Clinical and demographic features of patients with late hemorrhagic disease</title><author>Pirinccioglu, Ayfer Gözü ; Gurkan, Fuat ; Bosnak, Mehmet ; Acemoglu, Hamit ; Davutoglu, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5689-59ac7123386bfb954cf64123c1cf4798ad908635e258fe5bac33cb537becc2273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age</topic><topic>Antibiotics</topic><topic>Babies</topic><topic>Bleeding</topic><topic>Brain</topic><topic>Breast milk</topic><topic>Computed tomography</topic><topic>Consciousness</topic><topic>Demography</topic><topic>Feeding</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Hemorrhagic disease</topic><topic>Historical account</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>intracranial hemorrhage</topic><topic>Intracranial Hemorrhages - diagnosis</topic><topic>Intracranial Hemorrhages - etiology</topic><topic>Intracranial Hemorrhages - prevention & control</topic><topic>Male</topic><topic>Neonates</topic><topic>newborn</topic><topic>Nutrient deficiency</topic><topic>prevention</topic><topic>Prophylaxis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Seizures</topic><topic>Skull</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Turkey</topic><topic>Vitamin deficiency</topic><topic>Vitamin K</topic><topic>Vitamin K - therapeutic use</topic><topic>vitamin k deficiency</topic><topic>Vitamin K Deficiency Bleeding - diagnosis</topic><topic>Vitamin K Deficiency Bleeding - prevention & control</topic><topic>vitamins</topic><topic>Vitamins - therapeutic use</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pirinccioglu, Ayfer Gözü</creatorcontrib><creatorcontrib>Gurkan, Fuat</creatorcontrib><creatorcontrib>Bosnak, Mehmet</creatorcontrib><creatorcontrib>Acemoglu, Hamit</creatorcontrib><creatorcontrib>Davutoglu, Mehmet</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pirinccioglu, Ayfer Gözü</au><au>Gurkan, Fuat</au><au>Bosnak, Mehmet</au><au>Acemoglu, Hamit</au><au>Davutoglu, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracranial hemorrhage: Clinical and demographic features of patients with late hemorrhagic disease</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2011-02</date><risdate>2011</risdate><volume>53</volume><issue>1</issue><spage>68</spage><epage>71</epage><pages>68-71</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background: This retrospective study presents clinical, demographical features and radiological findings as well as outcomes of 31 infants with intracranial hemorrhage (ICH) due to vitamin K deficiency and hence evaluates the risk factors involved.
Methods: Thirty‐one cases (17 males and 14 females) having a mean age of 52.52 ± 20.80 days with intracranial hemorrhage due to late hemorrhagic disease of the newborn (LHDN), hospitalized in our clinics were included in the study. Cranial computerized tomography (CT) was performed in all patients for the diagnosis and evaluation of ICH.
Results: It was found that the most frequent presenting symptoms were pallor (77.4%), seizures (58%), altered consciousness (58%), vomiting (44%) and poor feeding (35%). Pulsatile fontanel was found in 61% and bulging in 26%. Seven (22.5%) patients had prior history of antibiotic usage. All patients (93.5%) except two were breast fed. Sixteen (51.6%) were delivered at home. Eighteen (58%) had a history of single‐dose vitamin K prophylaxis on the first day of delivery. Parenchymal (44%), subdural (39%) or subarachnoidal (22.5%) bleeding was observed. Seven (22.6%) were exitus. During the follow‐up period (ranging from 3 months to 18 months) neurological examination findings were recorded.
Conclusion: Our results indicate that it may be questionable whether single‐dose vitamin K prophlaxis at birth is adequate for the prevention of LHDN and if a different timing of this prophylaxis should be made for the exclusively breast fed infants.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>20626632</pmid><doi>10.1111/j.1442-200X.2010.03199.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Antibiotics Babies Bleeding Brain Breast milk Computed tomography Consciousness Demography Feeding Female Hemorrhage Hemorrhagic disease Historical account Hospitals Humans Infant Infant, Newborn Infants intracranial hemorrhage Intracranial Hemorrhages - diagnosis Intracranial Hemorrhages - etiology Intracranial Hemorrhages - prevention & control Male Neonates newborn Nutrient deficiency prevention Prophylaxis Retrospective Studies Risk Factors Seizures Skull Tomography Tomography, X-Ray Computed Turkey Vitamin deficiency Vitamin K Vitamin K - therapeutic use vitamin k deficiency Vitamin K Deficiency Bleeding - diagnosis Vitamin K Deficiency Bleeding - prevention & control vitamins Vitamins - therapeutic use Vomiting |
| title | Intracranial hemorrhage: Clinical and demographic features of patients with late hemorrhagic disease |
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