Superoxide dismutase activity and zinc and copper concentrations in growth retardation
The aim of this study was to determine the effects of oral zinc treatment on red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) activity and zinc and copper concentrations in growth retardation.Thirty-five patients, average age of 11 yr, were selected. The control group consisted of 10 healthy ch...
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| Veröffentlicht in: | Biological trace element research 2004, Vol.102 (1-3), p.51-59 |
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| creator | Kocatürk, Pelin Aribal Kavas, Güzin Özelçi Erdeve, Ömer Siklar, Zeynep |
| description | The aim of this study was to determine the effects of oral zinc treatment on red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) activity and zinc and copper concentrations in growth retardation.Thirty-five patients, average age of 11 yr, were selected. The control group consisted of 10 healthy children whose average age was 10 yr. Superoxide dismutase activity was determined by spectrophotometer. Copper and zinc concentrations were measured by an atomic absorption spectrophotometer. The activity of Cu/Zn-SOD before zinc treatment was higher than the controls (p |
| doi_str_mv | 10.1385/bter:102:1-3:051 |
| format | Article |
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The control group consisted of 10 healthy children whose average age was 10 yr. Superoxide dismutase activity was determined by spectrophotometer. Copper and zinc concentrations were measured by an atomic absorption spectrophotometer. The activity of Cu/Zn-SOD before zinc treatment was higher than the controls (p<0.001). There was a decrease in Cu/Zn-SOD activity after zinc treatment (p<0.001) and the values after treatment were still higher than the controls (p<0.001). Plasma zinc concentrations before zinc treatment were lower than controls (p<0.01). After treatment, there was an increase in plasma zinc concentrations compared to controls and the patients' values before zinc treatment, respectively (p<0.001, p<0.001). After zinc treatment, plasma copper concentrations were decreased significantly (p<0.01). An increase in red cell zinc concentration (p<0.01) and a decrease in copper concentration (p<0.001), which were statistically significant, were seen after zinc treatment.The results suggested that there were significant alterations in Cu/Zn-SOD activity and zinc and copper concentrations during growth retardation. With zinc treatment, these parameters appeared to approach normal values.]]></description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>EISSN: 0163-4984</identifier><identifier>DOI: 10.1385/bter:102:1-3:051</identifier><identifier>PMID: 15621927</identifier><language>eng</language><publisher>United States: Humana Press</publisher><subject>Age ; Antioxidants - analysis ; atomic absorption spectrometry ; Child ; Children ; Copper ; Copper - blood ; enzyme activity ; Erythrocytes - enzymology ; Growth Disorders - blood ; Growth Disorders - drug therapy ; Growth Disorders - etiology ; Growth rate ; growth retardation ; Humans ; normal values ; patients ; Spectral analysis ; Statistical analysis ; Superoxide dismutase ; Superoxide Dismutase - blood ; Zinc ; Zinc - blood ; Zinc - deficiency ; Zinc - therapeutic use</subject><ispartof>Biological trace element research, 2004, Vol.102 (1-3), p.51-59</ispartof><rights>Humana Press Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-f926565f5dc4364f6adf85bdfe948cc869e8f0974565cd5c0dff925e623e7ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15621927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocatürk, Pelin Aribal</creatorcontrib><creatorcontrib>Kavas, Güzin Özelçi</creatorcontrib><creatorcontrib>Erdeve, Ömer</creatorcontrib><creatorcontrib>Siklar, Zeynep</creatorcontrib><title>Superoxide dismutase activity and zinc and copper concentrations in growth retardation</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description><![CDATA[The aim of this study was to determine the effects of oral zinc treatment on red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) activity and zinc and copper concentrations in growth retardation.Thirty-five patients, average age of 11 yr, were selected. The control group consisted of 10 healthy children whose average age was 10 yr. Superoxide dismutase activity was determined by spectrophotometer. Copper and zinc concentrations were measured by an atomic absorption spectrophotometer. The activity of Cu/Zn-SOD before zinc treatment was higher than the controls (p<0.001). There was a decrease in Cu/Zn-SOD activity after zinc treatment (p<0.001) and the values after treatment were still higher than the controls (p<0.001). Plasma zinc concentrations before zinc treatment were lower than controls (p<0.01). After treatment, there was an increase in plasma zinc concentrations compared to controls and the patients' values before zinc treatment, respectively (p<0.001, p<0.001). After zinc treatment, plasma copper concentrations were decreased significantly (p<0.01). An increase in red cell zinc concentration (p<0.01) and a decrease in copper concentration (p<0.001), which were statistically significant, were seen after zinc treatment.The results suggested that there were significant alterations in Cu/Zn-SOD activity and zinc and copper concentrations during growth retardation. With zinc treatment, these parameters appeared to approach normal values.]]></description><subject>Age</subject><subject>Antioxidants - analysis</subject><subject>atomic absorption spectrometry</subject><subject>Child</subject><subject>Children</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>enzyme activity</subject><subject>Erythrocytes - enzymology</subject><subject>Growth Disorders - blood</subject><subject>Growth Disorders - drug therapy</subject><subject>Growth Disorders - etiology</subject><subject>Growth rate</subject><subject>growth retardation</subject><subject>Humans</subject><subject>normal values</subject><subject>patients</subject><subject>Spectral analysis</subject><subject>Statistical analysis</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Zinc</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><subject>Zinc - therapeutic use</subject><issn>0163-4984</issn><issn>1559-0720</issn><issn>0163-4984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90U1rVDEUBuAgFjtW96700oWurub7Y3a2VCsUBDu6DZnkpKbM3IxJrlp_vbEzILgwm5OE5xw4vAg9I_g1YVq8WTcoS4LpkoxsiQV5gBZECDNiRfFDtMBEspEbzY_R41pvMSaKGvYIHRMhKTFULdCX63kHJf9MAYaQ6nZursLgfEvfU7sb3BSGX2ny9xefd932MnmYWnEt5akOaRpuSv7Rvg4Fmivh_vsJOopuU-HpoZ6g1buL1fnlePXx_Yfzt1ejZxq3MRoqhRRRBM-Z5FG6ELVYhwiGa--1NKAjNop35IPwOMTeIkBSBgoiO0Gv9mN3JX-boTa7TdXDZuMmyHO1WhmupMaiy5f_lVIRo5XWHZ7-A2_zXKa-hKVEc2Kkkh3hPfIl11og2l1JW1fuLMH2TzL2bHXxqT-oJZbZnkxveX6YO6-3EP42HKLo4MUeRJetuymp2s_XtEeI-9FccvYbw5qUSA</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Kocatürk, Pelin Aribal</creator><creator>Kavas, Güzin Özelçi</creator><creator>Erdeve, Ömer</creator><creator>Siklar, Zeynep</creator><general>Humana Press</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Superoxide dismutase activity and zinc and copper concentrations in growth retardation</title><author>Kocatürk, Pelin Aribal ; Kavas, Güzin Özelçi ; Erdeve, Ömer ; Siklar, Zeynep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-f926565f5dc4364f6adf85bdfe948cc869e8f0974565cd5c0dff925e623e7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Antioxidants - analysis</topic><topic>atomic absorption spectrometry</topic><topic>Child</topic><topic>Children</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>enzyme activity</topic><topic>Erythrocytes - enzymology</topic><topic>Growth Disorders - blood</topic><topic>Growth Disorders - drug therapy</topic><topic>Growth Disorders - etiology</topic><topic>Growth rate</topic><topic>growth retardation</topic><topic>Humans</topic><topic>normal values</topic><topic>patients</topic><topic>Spectral analysis</topic><topic>Statistical analysis</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><topic>Zinc</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><topic>Zinc - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocatürk, Pelin Aribal</creatorcontrib><creatorcontrib>Kavas, Güzin Özelçi</creatorcontrib><creatorcontrib>Erdeve, Ömer</creatorcontrib><creatorcontrib>Siklar, Zeynep</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocatürk, Pelin Aribal</au><au>Kavas, Güzin Özelçi</au><au>Erdeve, Ömer</au><au>Siklar, Zeynep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superoxide dismutase activity and zinc and copper concentrations in growth retardation</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>2004</date><risdate>2004</risdate><volume>102</volume><issue>1-3</issue><spage>51</spage><epage>59</epage><pages>51-59</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><eissn>0163-4984</eissn><abstract><![CDATA[The aim of this study was to determine the effects of oral zinc treatment on red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) activity and zinc and copper concentrations in growth retardation.Thirty-five patients, average age of 11 yr, were selected. The control group consisted of 10 healthy children whose average age was 10 yr. Superoxide dismutase activity was determined by spectrophotometer. Copper and zinc concentrations were measured by an atomic absorption spectrophotometer. The activity of Cu/Zn-SOD before zinc treatment was higher than the controls (p<0.001). There was a decrease in Cu/Zn-SOD activity after zinc treatment (p<0.001) and the values after treatment were still higher than the controls (p<0.001). Plasma zinc concentrations before zinc treatment were lower than controls (p<0.01). After treatment, there was an increase in plasma zinc concentrations compared to controls and the patients' values before zinc treatment, respectively (p<0.001, p<0.001). After zinc treatment, plasma copper concentrations were decreased significantly (p<0.01). An increase in red cell zinc concentration (p<0.01) and a decrease in copper concentration (p<0.001), which were statistically significant, were seen after zinc treatment.The results suggested that there were significant alterations in Cu/Zn-SOD activity and zinc and copper concentrations during growth retardation. With zinc treatment, these parameters appeared to approach normal values.]]></abstract><cop>United States</cop><pub>Humana Press</pub><pmid>15621927</pmid><doi>10.1385/bter:102:1-3:051</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biological trace element research, 2004, Vol.102 (1-3), p.51-59 |
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| language | eng |
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| subjects | Age Antioxidants - analysis atomic absorption spectrometry Child Children Copper Copper - blood enzyme activity Erythrocytes - enzymology Growth Disorders - blood Growth Disorders - drug therapy Growth Disorders - etiology Growth rate growth retardation Humans normal values patients Spectral analysis Statistical analysis Superoxide dismutase Superoxide Dismutase - blood Zinc Zinc - blood Zinc - deficiency Zinc - therapeutic use |
| title | Superoxide dismutase activity and zinc and copper concentrations in growth retardation |
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