GAD antibody-associated neurological illness and its relationship to gluten sensitivity
Hadjivassiliou M, Aeschlimann D, Grünewald RA, Sanders DS, Sharrack B, Woodroofe N. GAD antibody associated neurological illness and its relationship to gluten sensitivity. Acta Neurol Scand: 2011: 123: 175–180. © 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Background – The h...
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| container_title | Acta neurologica Scandinavica |
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| creator | Hadjivassiliou, M. Aeschlimann, D. Grünewald, R. A. Sanders, D. S. Sharrack, B. Woodroofe, N. |
| description | Hadjivassiliou M, Aeschlimann D, Grünewald RA, Sanders DS, Sharrack B, Woodroofe N. GAD antibody associated neurological illness and its relationship to gluten sensitivity.
Acta Neurol Scand: 2011: 123: 175–180.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Background – The high prevalence of gluten sensitivity in patients with stiff‐person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD‐antibody‐associated diseases.
Methods – We used ELISA assays for anti‐GAD and for serological markers of gluten sensitivity. Patients were recruited from clinics based at the Royal Hallamshire hospital, Sheffield, UK. Patients with gluten sensitivity were followed up after the introduction of a gluten‐free diet and serological testing was repeated.
Results – Six of seven (86%) patients with SPS were positive for anti‐GAD, mean titre 109 U/ml; This compared with 9/90 (11%) patients with idiopathic sporadic ataxia, mean titre 32 U/ml, 16/40 (40%) patients with gluten ataxia, mean titre 25 U/ml, and 6/10 patients with type 1 diabetes only, mean titre 8 U/ml. None of 32 patients with celiac disease only, and of 40 patients with genetic ataxia were positive for anti‐GAD. The titre of anti‐GAD reduced following the introduction of a gluten‐free diet in patients with SPS who had serological evidence of gluten sensitivity. The same was observed in patients with gluten ataxia and anti‐GAD antibodies. This was also associated with clinical improvement.
Conclusion – These findings suggest a link between gluten sensitivity and GAD antibody‐associated diseases. |
| doi_str_mv | 10.1111/j.1600-0404.2010.01356.x |
| format | Article |
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Acta Neurol Scand: 2011: 123: 175–180.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Background – The high prevalence of gluten sensitivity in patients with stiff‐person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD‐antibody‐associated diseases.
Methods – We used ELISA assays for anti‐GAD and for serological markers of gluten sensitivity. Patients were recruited from clinics based at the Royal Hallamshire hospital, Sheffield, UK. Patients with gluten sensitivity were followed up after the introduction of a gluten‐free diet and serological testing was repeated.
Results – Six of seven (86%) patients with SPS were positive for anti‐GAD, mean titre 109 U/ml; This compared with 9/90 (11%) patients with idiopathic sporadic ataxia, mean titre 32 U/ml, 16/40 (40%) patients with gluten ataxia, mean titre 25 U/ml, and 6/10 patients with type 1 diabetes only, mean titre 8 U/ml. None of 32 patients with celiac disease only, and of 40 patients with genetic ataxia were positive for anti‐GAD. The titre of anti‐GAD reduced following the introduction of a gluten‐free diet in patients with SPS who had serological evidence of gluten sensitivity. The same was observed in patients with gluten ataxia and anti‐GAD antibodies. This was also associated with clinical improvement.
Conclusion – These findings suggest a link between gluten sensitivity and GAD antibody‐associated diseases.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/j.1600-0404.2010.01356.x</identifier><identifier>PMID: 20456245</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; anti-GAD ; Antibodies ; Ataxia ; Autoantibodies - adverse effects ; Autoantibodies - biosynthesis ; Autoantibodies - blood ; Biological and medical sciences ; Celiac disease ; Celiac Disease - enzymology ; Celiac Disease - epidemiology ; Celiac Disease - immunology ; Comorbidity ; Diabetes mellitus ; Diets ; Enzyme-Linked Immunosorbent Assay ; Female ; Glutamate decarboxylase ; Glutamate Decarboxylase - blood ; Glutamate Decarboxylase - immunology ; Gluten ; gluten sensitivity ; gluten-free diet ; Hematologic and hematopoietic diseases ; Hospitals ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Neurology ; Prevalence ; Risk Factors ; stiff-person syndrome ; United Kingdom - epidemiology</subject><ispartof>Acta neurologica Scandinavica, 2011-03, Vol.123 (3), p.175-180</ispartof><rights>Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5356-dd35363c247bdbbd6574d21f1c799e58ddccb2d009e8d7ff4a3ac4544e6654003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0404.2010.01356.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0404.2010.01356.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23842662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20456245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hadjivassiliou, M.</creatorcontrib><creatorcontrib>Aeschlimann, D.</creatorcontrib><creatorcontrib>Grünewald, R. A.</creatorcontrib><creatorcontrib>Sanders, D. S.</creatorcontrib><creatorcontrib>Sharrack, B.</creatorcontrib><creatorcontrib>Woodroofe, N.</creatorcontrib><title>GAD antibody-associated neurological illness and its relationship to gluten sensitivity</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Hadjivassiliou M, Aeschlimann D, Grünewald RA, Sanders DS, Sharrack B, Woodroofe N. GAD antibody associated neurological illness and its relationship to gluten sensitivity.
Acta Neurol Scand: 2011: 123: 175–180.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Background – The high prevalence of gluten sensitivity in patients with stiff‐person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD‐antibody‐associated diseases.
Methods – We used ELISA assays for anti‐GAD and for serological markers of gluten sensitivity. Patients were recruited from clinics based at the Royal Hallamshire hospital, Sheffield, UK. Patients with gluten sensitivity were followed up after the introduction of a gluten‐free diet and serological testing was repeated.
Results – Six of seven (86%) patients with SPS were positive for anti‐GAD, mean titre 109 U/ml; This compared with 9/90 (11%) patients with idiopathic sporadic ataxia, mean titre 32 U/ml, 16/40 (40%) patients with gluten ataxia, mean titre 25 U/ml, and 6/10 patients with type 1 diabetes only, mean titre 8 U/ml. None of 32 patients with celiac disease only, and of 40 patients with genetic ataxia were positive for anti‐GAD. The titre of anti‐GAD reduced following the introduction of a gluten‐free diet in patients with SPS who had serological evidence of gluten sensitivity. The same was observed in patients with gluten ataxia and anti‐GAD antibodies. This was also associated with clinical improvement.
Conclusion – These findings suggest a link between gluten sensitivity and GAD antibody‐associated diseases.</description><subject>Adult</subject><subject>Aged</subject><subject>anti-GAD</subject><subject>Antibodies</subject><subject>Ataxia</subject><subject>Autoantibodies - adverse effects</subject><subject>Autoantibodies - biosynthesis</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Celiac disease</subject><subject>Celiac Disease - enzymology</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - immunology</subject><subject>Comorbidity</subject><subject>Diabetes mellitus</subject><subject>Diets</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Glutamate decarboxylase</subject><subject>Glutamate Decarboxylase - blood</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>Gluten</subject><subject>gluten sensitivity</subject><subject>gluten-free diet</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>stiff-person syndrome</subject><subject>United Kingdom - epidemiology</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEURi1ERdPCX0DeIFYT_PbMgkXUR0CKUqkKisTG8tie4uDMhLEHkn-Pp0nDEm_8uOezrXsAgBhNcR6fNlMsECoQQ2xKUD5FmHIx3b8Ck3PhNZgghHAhKGaX4CrGTd4RydgbcEkQ44IwPgHr-ewW6jb5urOHQsfYGa-Ts7B1Q9-F7skbHaAPoXUxZtBCnyLsXdDJd2384XcwdfApDMm1MLo2-uR_-3R4Cy4aHaJ7d5qvwbf7u9XNl2LxMP96M1sUhucfF9ZSTgU1hMna1rUVXDJLcIONrCrHS2uNqYlFqHKllU3DNNWGccacEJwhRK_Bx-O9u777NbiY1NZH40LQreuGqEpZMcmoIP8nWUkxqUiVyfcncqi3zqpd77e6P6iXrmXgwwnQMben6XVrfPzH0ZIR8fzk5yP3xwd3ONcxUqNFtVGjLDXKUqNF9WxR7dVseTeucr445n1Mbn_O6_6nEpJKrtbLuVrJx2rxfbVUa_oXNKGfQQ</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Hadjivassiliou, M.</creator><creator>Aeschlimann, D.</creator><creator>Grünewald, R. A.</creator><creator>Sanders, D. S.</creator><creator>Sharrack, B.</creator><creator>Woodroofe, N.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201103</creationdate><title>GAD antibody-associated neurological illness and its relationship to gluten sensitivity</title><author>Hadjivassiliou, M. ; Aeschlimann, D. ; Grünewald, R. A. ; Sanders, D. S. ; Sharrack, B. ; Woodroofe, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5356-dd35363c247bdbbd6574d21f1c799e58ddccb2d009e8d7ff4a3ac4544e6654003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>anti-GAD</topic><topic>Antibodies</topic><topic>Ataxia</topic><topic>Autoantibodies - adverse effects</topic><topic>Autoantibodies - biosynthesis</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Celiac disease</topic><topic>Celiac Disease - enzymology</topic><topic>Celiac Disease - epidemiology</topic><topic>Celiac Disease - immunology</topic><topic>Comorbidity</topic><topic>Diabetes mellitus</topic><topic>Diets</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Glutamate decarboxylase</topic><topic>Glutamate Decarboxylase - blood</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>Gluten</topic><topic>gluten sensitivity</topic><topic>gluten-free diet</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>stiff-person syndrome</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hadjivassiliou, M.</creatorcontrib><creatorcontrib>Aeschlimann, D.</creatorcontrib><creatorcontrib>Grünewald, R. A.</creatorcontrib><creatorcontrib>Sanders, D. S.</creatorcontrib><creatorcontrib>Sharrack, B.</creatorcontrib><creatorcontrib>Woodroofe, N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hadjivassiliou, M.</au><au>Aeschlimann, D.</au><au>Grünewald, R. A.</au><au>Sanders, D. S.</au><au>Sharrack, B.</au><au>Woodroofe, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GAD antibody-associated neurological illness and its relationship to gluten sensitivity</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>2011-03</date><risdate>2011</risdate><volume>123</volume><issue>3</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Hadjivassiliou M, Aeschlimann D, Grünewald RA, Sanders DS, Sharrack B, Woodroofe N. GAD antibody associated neurological illness and its relationship to gluten sensitivity.
Acta Neurol Scand: 2011: 123: 175–180.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Background – The high prevalence of gluten sensitivity in patients with stiff‐person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD‐antibody‐associated diseases.
Methods – We used ELISA assays for anti‐GAD and for serological markers of gluten sensitivity. Patients were recruited from clinics based at the Royal Hallamshire hospital, Sheffield, UK. Patients with gluten sensitivity were followed up after the introduction of a gluten‐free diet and serological testing was repeated.
Results – Six of seven (86%) patients with SPS were positive for anti‐GAD, mean titre 109 U/ml; This compared with 9/90 (11%) patients with idiopathic sporadic ataxia, mean titre 32 U/ml, 16/40 (40%) patients with gluten ataxia, mean titre 25 U/ml, and 6/10 patients with type 1 diabetes only, mean titre 8 U/ml. None of 32 patients with celiac disease only, and of 40 patients with genetic ataxia were positive for anti‐GAD. The titre of anti‐GAD reduced following the introduction of a gluten‐free diet in patients with SPS who had serological evidence of gluten sensitivity. The same was observed in patients with gluten ataxia and anti‐GAD antibodies. This was also associated with clinical improvement.
Conclusion – These findings suggest a link between gluten sensitivity and GAD antibody‐associated diseases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20456245</pmid><doi>10.1111/j.1600-0404.2010.01356.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged anti-GAD Antibodies Ataxia Autoantibodies - adverse effects Autoantibodies - biosynthesis Autoantibodies - blood Biological and medical sciences Celiac disease Celiac Disease - enzymology Celiac Disease - epidemiology Celiac Disease - immunology Comorbidity Diabetes mellitus Diets Enzyme-Linked Immunosorbent Assay Female Glutamate decarboxylase Glutamate Decarboxylase - blood Glutamate Decarboxylase - immunology Gluten gluten sensitivity gluten-free diet Hematologic and hematopoietic diseases Hospitals Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neurology Prevalence Risk Factors stiff-person syndrome United Kingdom - epidemiology |
| title | GAD antibody-associated neurological illness and its relationship to gluten sensitivity |
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