The unfolded protein response: how protein folding became a restrictive aspect for innate immunity and B lymphocytes

Chaperone production is an essential step for proper folding of certain proteins. Accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER) lumen triggers a signalling pathway named unfolded protein response (UPR). Upon activation, the UPR pathway augments transcription of ER...

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Veröffentlicht in:	Scandinavian journal of immunology 2011-05, Vol.73 (5), p.436-448
Hauptverfasser:	Costa, C Z F, da Rosa, S E A, de Camargo, M M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B-Lymphocytes - immunology Chaperones Data processing Endoplasmic reticulum Endoplasmic Reticulum - immunology Humans Immune response Immunity Immunity, Innate - immunology Lymphocytes B Models, Immunological Molecular Chaperones - immunology Protein Folding Reviews Signal transduction Transcription Translation Unfolded Protein Response - immunology
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