Identification of t(17;22)(q22;q13) ( COL1A1/PDGFB ) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarrays

Summary Dermatofibrosarcoma protuberans is genetically characterized by the translocation t(17;22)(q22;q13) resulting in the PDGFB/COL1A1 fusion gene. Fluorescence in situ hybridization with specific probes enables a rapid detection of this gene. In this study, the presence of the translocation t(17...

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Veröffentlicht in:	Human pathology 2011-02, Vol.42 (2), p.176-184
Hauptverfasser:	Segura, Sonia, MD, Salgado, Rocío, MSc, Toll, Agustí, MD, Martín-Ezquerra, Gemma, MD, Yébenes, Mireia, MD, Sáez, Amparo, MD, Solé, Francesc, PhD, Barranco, Carlos, MD, Umbert, Pablo, MD, Espinet, Blanca, PhD, Pujol, Ramón M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Chromosomes Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 22 Collagen Type I - genetics Collagen Type I - metabolism Deoxyribonucleic acid Dermatofibrosarcoma - genetics Dermatofibrosarcoma - metabolism Dermatofibrosarcoma - pathology Dermatofibrosarcoma protuberans Dermatology Dermatopathology DNA Evolution Female Fluorescence in situ hybridization Genes Histiocytoma, Benign Fibrous - genetics Histiocytoma, Benign Fibrous - metabolism Histiocytoma, Benign Fibrous - pathology Humans Hybridization In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Paraffin Embedding Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-sis - genetics Proto-Oncogene Proteins c-sis - metabolism Tissue Array Analysis Tissue microarrays Translocation, Genetic Tumors of the skin and soft tissue. Premalignant lesions Young Adult
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