Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis
Šaňák D, Herzig R, Zapletalová J, Horák D, Král M, Školoudík D, Bártková A, Veverka T, Heřman M, Kaňovský P. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis. Acta Neurol Scand: 2011: 123: 339–344. © 2010 John Wiley & Sons A/S. Objectives – In...
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| creator | Šaňák, D. Herzig, R. Zapletalová, J. Horák, D. Král, M. Školoudík, D. Bártková, A. Veverka, T. Heřman, M. Kaňovský, P. |
| description | Šaňák D, Herzig R, Zapletalová J, Horák D, Král M, Školoudík D, Bártková A, Veverka T, Heřman M, Kaňovský P. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis.
Acta Neurol Scand: 2011: 123: 339–344.
© 2010 John Wiley & Sons A/S.
Objectives – Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT.
Patients and Methods – The set of 125 patients with consecutive hemispheric IS (78 men; mean age 66.0 ± 12.1 years) treated with IVT within 3 h was analyzed. DWI volume was measured on admission. Good outcome was defined as a score 0‐2 in modified Rankin Scale.
Results – Multivariate logistic regression analysis showed initial NIHSS as an independent predictor of good outcome (P = 0.001). ROC curves showed baseline NIHSS ≤13.5 points and DWI volume ≤13.7 ml as cut‐offs related to good outcome.
Conclusions – The initial NIHSS and DWI volume might be the predictors for good clinical outcome in acute stroke patients treated with IVT. The initial NIHSS score seems to be more accurate. |
| doi_str_mv | 10.1111/j.1600-0404.2010.01401.x |
| format | Article |
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Acta Neurol Scand: 2011: 123: 339–344.
© 2010 John Wiley & Sons A/S.
Objectives – Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT.
Patients and Methods – The set of 125 patients with consecutive hemispheric IS (78 men; mean age 66.0 ± 12.1 years) treated with IVT within 3 h was analyzed. DWI volume was measured on admission. Good outcome was defined as a score 0‐2 in modified Rankin Scale.
Results – Multivariate logistic regression analysis showed initial NIHSS as an independent predictor of good outcome (P = 0.001). ROC curves showed baseline NIHSS ≤13.5 points and DWI volume ≤13.7 ml as cut‐offs related to good outcome.
Conclusions – The initial NIHSS and DWI volume might be the predictors for good clinical outcome in acute stroke patients treated with IVT. The initial NIHSS score seems to be more accurate.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/j.1600-0404.2010.01401.x</identifier><identifier>PMID: 20597864</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age ; Aged ; Biological and medical sciences ; Brain Ischemia - drug therapy ; clinical outcome ; Diffusion Magnetic Resonance Imaging ; Female ; Fibrinolytic Agents - administration & dosage ; Fibrinolytic Agents - therapeutic use ; Humans ; infarct volume ; Injections, Intravenous ; Intravenous administration ; intravenous thrombolysis ; Ischemia ; ischemic stroke ; Logistic Models ; magnetic resonance imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Prognosis ; Regression analysis ; Retrospective Studies ; ROC Curve ; Severity of Illness Index ; Stroke ; Stroke - drug therapy ; stroke severity ; thrombolysis ; Thrombolytic Therapy ; Tissue Plasminogen Activator - administration & dosage ; Tissue Plasminogen Activator - therapeutic use ; Treatment Outcome</subject><ispartof>Acta neurologica Scandinavica, 2011-05, Vol.123 (5), p.339-344</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4191-ed4b81a660a89d680cf5dabe494abaa0cbdccefdb1186d1a4f7ee381e27a9ac83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0404.2010.01401.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0404.2010.01401.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24021475$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20597864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šaňák, D.</creatorcontrib><creatorcontrib>Herzig, R.</creatorcontrib><creatorcontrib>Zapletalová, J.</creatorcontrib><creatorcontrib>Horák, D.</creatorcontrib><creatorcontrib>Král, M.</creatorcontrib><creatorcontrib>Školoudík, D.</creatorcontrib><creatorcontrib>Bártková, A.</creatorcontrib><creatorcontrib>Veverka, T.</creatorcontrib><creatorcontrib>Heřman, M.</creatorcontrib><creatorcontrib>Kaňovský, P.</creatorcontrib><title>Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Šaňák D, Herzig R, Zapletalová J, Horák D, Král M, Školoudík D, Bártková A, Veverka T, Heřman M, Kaňovský P. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis.
Acta Neurol Scand: 2011: 123: 339–344.
© 2010 John Wiley & Sons A/S.
Objectives – Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT.
Patients and Methods – The set of 125 patients with consecutive hemispheric IS (78 men; mean age 66.0 ± 12.1 years) treated with IVT within 3 h was analyzed. DWI volume was measured on admission. Good outcome was defined as a score 0‐2 in modified Rankin Scale.
Results – Multivariate logistic regression analysis showed initial NIHSS as an independent predictor of good outcome (P = 0.001). ROC curves showed baseline NIHSS ≤13.5 points and DWI volume ≤13.7 ml as cut‐offs related to good outcome.
Conclusions – The initial NIHSS and DWI volume might be the predictors for good clinical outcome in acute stroke patients treated with IVT. The initial NIHSS score seems to be more accurate.</description><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - drug therapy</subject><subject>clinical outcome</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Humans</subject><subject>infarct volume</subject><subject>Injections, Intravenous</subject><subject>Intravenous administration</subject><subject>intravenous thrombolysis</subject><subject>Ischemia</subject><subject>ischemic stroke</subject><subject>Logistic Models</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Stroke</subject><subject>Stroke - drug therapy</subject><subject>stroke severity</subject><subject>thrombolysis</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - administration & dosage</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYsvCX0C-IE4pduIkzoHDarW7ILUFIRBHa2JPWHeTuNgO2_57HFrKkbl47Pe9kTWPEMrZkqd6t13yirGMCSaWOUuvjAvGl_snZHEWnpIFY4xnVcHFBXkRwjbd8lqI5-QiZ2VTy0osSPvZo7E6Oh-o6-gP5wzVvR2thp66KWo3ILUjBT1FpCF694B0B9HiGAONHiGioY823icqeviFo5uScO_d0Lr-EGx4SZ510Ad8dTovybfbm6_XH7LVp7uP11erTAve8AyNaCWHqmIgG1NJprvSQIuiEdACMN0arbEzLeeyMhxEVyMWkmNeQwNaFpfk7XHuzrufE4aoBhs09j2MmP6kZN2IOudN83-ylIJL1lSJfH0ip3ZAo3beDuAP6u8CE_DmBEBIK-s8jNqGf5xgORd1mbj3R-7R9ng465ypOVC1VXNuas5NzYGqP4Gqvbra3Mxd8mdHvw0R92c_-AdV1UVdqu-bO8XX5Waz_rJS6-I3qJGk_g</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Šaňák, D.</creator><creator>Herzig, R.</creator><creator>Zapletalová, J.</creator><creator>Horák, D.</creator><creator>Král, M.</creator><creator>Školoudík, D.</creator><creator>Bártková, A.</creator><creator>Veverka, T.</creator><creator>Heřman, M.</creator><creator>Kaňovský, P.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201105</creationdate><title>Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis</title><author>Šaňák, D. ; Herzig, R. ; Zapletalová, J. ; Horák, D. ; Král, M. ; Školoudík, D. ; Bártková, A. ; Veverka, T. ; Heřman, M. ; Kaňovský, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4191-ed4b81a660a89d680cf5dabe494abaa0cbdccefdb1186d1a4f7ee381e27a9ac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - drug therapy</topic><topic>clinical outcome</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Fibrinolytic Agents - administration & dosage</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Humans</topic><topic>infarct volume</topic><topic>Injections, Intravenous</topic><topic>Intravenous administration</topic><topic>intravenous thrombolysis</topic><topic>Ischemia</topic><topic>ischemic stroke</topic><topic>Logistic Models</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Stroke</topic><topic>Stroke - drug therapy</topic><topic>stroke severity</topic><topic>thrombolysis</topic><topic>Thrombolytic Therapy</topic><topic>Tissue Plasminogen Activator - administration & dosage</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šaňák, D.</creatorcontrib><creatorcontrib>Herzig, R.</creatorcontrib><creatorcontrib>Zapletalová, J.</creatorcontrib><creatorcontrib>Horák, D.</creatorcontrib><creatorcontrib>Král, M.</creatorcontrib><creatorcontrib>Školoudík, D.</creatorcontrib><creatorcontrib>Bártková, A.</creatorcontrib><creatorcontrib>Veverka, T.</creatorcontrib><creatorcontrib>Heřman, M.</creatorcontrib><creatorcontrib>Kaňovský, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šaňák, D.</au><au>Herzig, R.</au><au>Zapletalová, J.</au><au>Horák, D.</au><au>Král, M.</au><au>Školoudík, D.</au><au>Bártková, A.</au><au>Veverka, T.</au><au>Heřman, M.</au><au>Kaňovský, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>2011-05</date><risdate>2011</risdate><volume>123</volume><issue>5</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Šaňák D, Herzig R, Zapletalová J, Horák D, Král M, Školoudík D, Bártková A, Veverka T, Heřman M, Kaňovský P. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis.
Acta Neurol Scand: 2011: 123: 339–344.
© 2010 John Wiley & Sons A/S.
Objectives – Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT.
Patients and Methods – The set of 125 patients with consecutive hemispheric IS (78 men; mean age 66.0 ± 12.1 years) treated with IVT within 3 h was analyzed. DWI volume was measured on admission. Good outcome was defined as a score 0‐2 in modified Rankin Scale.
Results – Multivariate logistic regression analysis showed initial NIHSS as an independent predictor of good outcome (P = 0.001). ROC curves showed baseline NIHSS ≤13.5 points and DWI volume ≤13.7 ml as cut‐offs related to good outcome.
Conclusions – The initial NIHSS and DWI volume might be the predictors for good clinical outcome in acute stroke patients treated with IVT. The initial NIHSS score seems to be more accurate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20597864</pmid><doi>10.1111/j.1600-0404.2010.01401.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Aged Biological and medical sciences Brain Ischemia - drug therapy clinical outcome Diffusion Magnetic Resonance Imaging Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use Humans infarct volume Injections, Intravenous Intravenous administration intravenous thrombolysis Ischemia ischemic stroke Logistic Models magnetic resonance imaging Male Medical sciences Middle Aged Nervous system involvement in other diseases. Miscellaneous Neurology Prognosis Regression analysis Retrospective Studies ROC Curve Severity of Illness Index Stroke Stroke - drug therapy stroke severity thrombolysis Thrombolytic Therapy Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use Treatment Outcome |
| title | Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis |
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