Disease protection and interleukin-10 induction by endogenous interferon-β in multiple sclerosis?

Objective: An immune activation response resembling virus or type I interferon responses has been observed in untreated multiple sclerosis (MS), but its pathogenic significance is uncertain. We studied the relationship between a type I interferon‐like response in untreated patients with MS and dise...

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Veröffentlicht in:	European journal of neurology 2011-02, Vol.18 (2), p.266-272
Hauptverfasser:	Hesse, D., Krakauer, M., Lund, H., Søndergaard, H. B., Limborg, S. J. W., Soelberg Sørensen, P., Sellebjerg, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antibodies, Neutralizing - blood beta -Interferon Blood cells DNA microarrays Female Foxp3 protein Gadolinium Gene Expression Gene Expression Profiling GTP-Binding Proteins - biosynthesis GTP-Binding Proteins - genetics Humans Immune response Immunoregulation Inflammatory diseases Interferon Interferon-beta - immunology interferon-β Interleukin 1 Interleukin 10 Interleukin-10 - biosynthesis Interleukin-10 - genetics Leukocytes (mononuclear) Magnetic resonance imaging Male Medical imaging Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - genetics Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - metabolism Myxovirus Resistance Proteins Oligonucleotide Array Sequence Analysis Patients Polymerase chain reaction Resonance Reverse Transcriptase Polymerase Chain Reaction RNA-directed DNA polymerase Viruses Young Adult
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