Aminoglutethimide-induced leucopenia in a mouse model: effects of metabolic and structural determinates

A model of human leucopenia has been developed further in the female mouse. Following daily administration to female mice of 50 mg/kg of the aromatase inhibitor aminoglutethimide, significant falls in platelet and white cell counts occurred after 2 and 3 weeks. At week 4, drug dosage was stopped and...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2003-12, Vol.15 (1), p.27-32
Hauptverfasser:	Coleman, Michael D., Khalaf, Laila F., Nicholls, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agranulocytosis Animal Haemotoxicity Leucopenia Platelet
Online-Zugang:	Volltext
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