Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide

We investigated the involvement of nitric oxide (NO) and prostaglandins (PGs) in the damage to the blood-brain barrier (BBB) induced by lipopolysaccharide (LPS), using fluorescein as a tracer in mice. Aminoguanidine, a competitive inhibitor of inducible NO synthase (iNOS), when administered s.c. at...

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Veröffentlicht in:	Environmental toxicology and pharmacology 1998, Vol.5 (1), p.35-41
Hauptverfasser:	Minami, Takeshi, Okazaki, Jiro, Kawabata, Atsufumi, Kawaki, Hideko, Okazaki, Yuko, Tohno, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoguanidine Blood-brain barrier Dexamethasone Indomethacin l-Arginine Lipopolysaccharide N G-Nitro- l-arginine methyl ester Nitric oxide Prostaglandin
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