Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms

Key Points Dengue is an emerging infection of tropical and subtropical regions caused by a group of four serotypes of dengue virus that are transmitted to humans by Aedes spp. mosquitoes. Infection with one dengue virus serotype provides long-lasting protective immunity to that serotype, but only sh...

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Veröffentlicht in:	Nature reviews. Immunology 2011-08, Vol.11 (8), p.532-543
1. Verfasser:	Rothman, Alan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/2152 631/326/596/1413 631/326/596/2553 Animals Antibodies Antigens, Viral - immunology Aquatic insects Biomedical and Life Sciences Biomedicine Complications and side effects Cytokine storm Cytokines - immunology Cytokines - metabolism Dengue Dengue - immunology Dengue - metabolism Dengue - virology Dengue fever Dengue Vaccines - immunology Dengue Virus - immunology Dengue viruses Development and progression Health aspects Humans Illnesses Immune response Immunology Infections Laboratory animals Mosquitoes Permeability Plasma Prevention review-article Vaccines Vector-borne diseases Viral diseases Viral vaccines Viruses
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