A critical review of methods for the assessment of patient-level interactions in individual participant data meta-analysis of randomized trials, and guidance for practitioners

Abstract Objective Treatments may be more effective in some patients than others, and individual participant data (IPD) meta-analysis of randomized trials provides perhaps the best method of investigating treatment-covariate interactions. Various methods are used; we provide a comprehensive critique...

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Veröffentlicht in:	Journal of clinical epidemiology 2011-09, Vol.64 (9), p.949-967
Hauptverfasser:	Fisher, D.J, Copas, A.J, Tierney, J.F, Parmar, M.K.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bias Biological and medical sciences Data Interpretation, Statistical Epidemiology Estimates Health participants Humans Interaction Internal Medicine IPD Medical sciences MEDLINE Meta-analysis Meta-Analysis as Topic Methodology Methods Miscellaneous Models, Statistical Outcome Assessment (Health Care) Public health. Hygiene Public health. Hygiene-occupational medicine Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data RCT Research Design Studies Subgroup
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