Safety and Efficacy of the Oral Direct Factor Xa Inhibitor Apixaban in Japanese Patients With Non-Valvular Atrial Fibrillation: The ARISTOTLE-J Study

Background: Guidelines recommend warfarin as the standard of care for patients with atrial fibrillation (AF) at moderate or high risk for stroke. This phase II study assessed the effects of 2 doses of the factor Xa inhibitor apixaban vs. warfarin in Japanese patients with non-valvular AF. The compos...

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Veröffentlicht in:	Circulation Journal 2011, Vol.75(8), pp.1852-1859
Hauptverfasser:	Ogawa, Satoshi, Shinohara, Yukito, Kanmuri, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Anticoagulants - administration & dosage Anticoagulants - adverse effects Apixaban Asian Continental Ancestry Group Atrial Fibrillation - drug therapy Double-Blind Method Factor Xa Inhibitors Female Humans Japan Japanese patients Male Non-valvular atrial fibrillation Oral anticoagulant Pyrazoles - administration & dosage Pyrazoles - adverse effects Pyridones - administration & dosage Pyridones - adverse effects Time Factors Warfarin - administration & dosage Warfarin - adverse effects
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