The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation

Objective To determine the impact of reproductive aging on oocyte mitochondrial quantity, function, and DNA (mtDNA) integrity. Design Prospective observational study. Setting IVF clinic in a tertiary academic care center. Patient(s) One hundred two oocytes from 32 women undergoing IVF. Intervention(...

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Veröffentlicht in:	Fertility and sterility 2011-08, Vol.96 (2), p.384-388
Hauptverfasser:	Duran, Hakan E., M.D, Simsek-Duran, Fatma, M.D, Oehninger, Sergio C., M.D., Ph.D, Jones, Howard W., M.D, Castora, Frank J., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Academic Medical Centers adenosine triphosphate Adenosine Triphosphate - metabolism Adult Age Factors aging Aging - genetics Aging - pathology Analysis of Variance ATP content Biological and medical sciences Cells, Cultured Cellular Senescence - genetics common deletion developmental stages DNA Damage DNA, Mitochondrial - metabolism Female Fertilization in Vitro follicle-stimulating hormone FSH Gynecology. Andrology. Obstetrics human oocytes Humans in vitro fertilization Internal Medicine Logistic Models Medical sciences Meiotic Prophase I Metaphase metaphase 2 mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA observational studies Obstetrics and Gynecology Oocyte Retrieval oocytes Oocytes - metabolism Oocytes - pathology Ovulation Induction patients prophase Prospective Studies regression analysis Reproduction - genetics senescence Virginia women Young Adult
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