p38α MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation

Many protein kinase functions, including autophosphorylation in trans, require dimerization, possibly by activation segment exchange. Such dimers have been reported for a few autophosphorylating protein kinases, but not for mitogen-activated protein kinases (MAPKs). Activation of MAPKs proceeds not...

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Veröffentlicht in:	Journal of molecular biology 2011-08, Vol.411 (2), p.474-485
Hauptverfasser:	Rothweiler, Ulli, Åberg, Espen, Johnson, Kenneth A., Hansen, Tom E., Jørgensen, Jorunn B., Engh, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals autoactivation Crystallography, X-Ray dimerization domain swapping gel chromatography homodimerization mitogen-activated protein kinase Models, Molecular Molecular Sequence Data noncanonical p38 Mitogen-Activated Protein Kinases - chemistry p38 Mitogen-Activated Protein Kinases - metabolism p38α Phosphorylation Protein Multimerization Protein Structure, Quaternary Salmo salar Sequence Homology, Amino Acid Tyrosine - metabolism
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