Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart

Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart

Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4mg Cd/kg BW i.p.)...

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Veröffentlicht in:Environmental toxicology and pharmacology 2006-09, Vol.22 (2), p.219-224
Hauptverfasser: Ognjanović, Branka I, Marković, Snežana D, Pavlović, Sladjan Z, Zikić, Radoslav V, Stajn, Andraš Š, Saičić, Zorica S
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container_end_page 224
container_issue 2
container_start_page 219
container_title Environmental toxicology and pharmacology
container_volume 22
creator Ognjanović, Branka I
Marković, Snežana D
Pavlović, Sladjan Z
Zikić, Radoslav V
Stajn, Andraš Š
Saičić, Zorica S
description Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4mg Cd/kg BW i.p.), CoQ(10) (20mg CoQ(10)/kg BW i.m.) and Vit E (20IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ(10) and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ(10) and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.
doi_str_mv 10.1016/j.etap.2006.03.008
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title Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart
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