Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report
Cognitive performance often is impaired permanently in long-term brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may result in improved functionality of damaged tissue. In this pilot study, clinica...
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| Veröffentlicht in: | Cancer 2011-08, Vol.117 (15), p.3434-3444 |
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| creator | SCHELLART, Nico A. M REITS, Dik VAN DER KLEIJ, Adrian J STALPERS, Lukas J. A |
| description | Cognitive performance often is impaired permanently in long-term brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may result in improved functionality of damaged tissue. In this pilot study, clinical neurophysiologic tests were used to assess the effect of HBOT on brain performance.
Ten long-term brain tumor survivors received HBOT for severe cognitive deficits after neurosurgery and radiosurgery. Patients were tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a quantitative electroencephalographic (EEG) examination, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory performance, and 2 cognitive tests, the number connection test (NCT) and the continuous reaction time test (CRTT). Late event-related components (LERCs) of averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from whole-head activity maps. For comparison, a control group of healthy individuals (no HBOT) also were investigated.
After HBOT, the amplitude of the LERC with the longest latency, P3b (involved in object interpretation) was improved significantly (P = .02). The amplitudes of the N200 (occipital, negative) and the intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of a small, positive, occipital visual component did not change. Neither latencies nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) latencies were longer in survivors than in healthy individuals. The NCT produced inconclusive results, but the IQCODE revealed an improvement. When outcomes of the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT appeared to provide substantial improvement (P |
| doi_str_mv | 10.1002/cncr.25874 |
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Ten long-term brain tumor survivors received HBOT for severe cognitive deficits after neurosurgery and radiosurgery. Patients were tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a quantitative electroencephalographic (EEG) examination, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory performance, and 2 cognitive tests, the number connection test (NCT) and the continuous reaction time test (CRTT). Late event-related components (LERCs) of averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from whole-head activity maps. For comparison, a control group of healthy individuals (no HBOT) also were investigated.
After HBOT, the amplitude of the LERC with the longest latency, P3b (involved in object interpretation) was improved significantly (P = .02). The amplitudes of the N200 (occipital, negative) and the intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of a small, positive, occipital visual component did not change. Neither latencies nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) latencies were longer in survivors than in healthy individuals. The NCT produced inconclusive results, but the IQCODE revealed an improvement. When outcomes of the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT appeared to provide substantial improvement (P<.006).
On the basis of the current results, the authors concluded tentatively that HBOT improves neurophysiologic performance in long-term brain tumor survivors.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.25874</identifier><identifier>PMID: 21287528</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brain Neoplasms - physiopathology ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - surgery ; Cognition ; Electroencephalography ; Female ; Humans ; Hyperbaric Oxygenation ; Male ; Medical sciences ; Middle Aged ; Neurology ; Surveys and Questionnaires ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Cancer, 2011-08, Vol.117 (15), p.3434-3444</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c275t-bece1e2722e5eb10d0e3ed8b1b3b45510a4a0b50825d338806543d61bfd77a743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24363331$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21287528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHELLART, Nico A. M</creatorcontrib><creatorcontrib>REITS, Dik</creatorcontrib><creatorcontrib>VAN DER KLEIJ, Adrian J</creatorcontrib><creatorcontrib>STALPERS, Lukas J. A</creatorcontrib><title>Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Cognitive performance often is impaired permanently in long-term brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may result in improved functionality of damaged tissue. In this pilot study, clinical neurophysiologic tests were used to assess the effect of HBOT on brain performance.
Ten long-term brain tumor survivors received HBOT for severe cognitive deficits after neurosurgery and radiosurgery. Patients were tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a quantitative electroencephalographic (EEG) examination, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory performance, and 2 cognitive tests, the number connection test (NCT) and the continuous reaction time test (CRTT). Late event-related components (LERCs) of averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from whole-head activity maps. For comparison, a control group of healthy individuals (no HBOT) also were investigated.
After HBOT, the amplitude of the LERC with the longest latency, P3b (involved in object interpretation) was improved significantly (P = .02). The amplitudes of the N200 (occipital, negative) and the intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of a small, positive, occipital visual component did not change. Neither latencies nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) latencies were longer in survivors than in healthy individuals. The NCT produced inconclusive results, but the IQCODE revealed an improvement. When outcomes of the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT appeared to provide substantial improvement (P<.006).
On the basis of the current results, the authors concluded tentatively that HBOT improves neurophysiologic performance in long-term brain tumor survivors.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - physiopathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - surgery</subject><subject>Cognition</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperbaric Oxygenation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkdtqFEEQhhtRzCZ64wNI34gQmNiH6e3WuzWoCQSzhBW8G_pQs2mZmR6rZ8R5Dl_YjrvqTRVFfVVU_T8hLzi74IyJN37weCGU0fUjsuLsra4Yr8VjsmKMmUrV8usJOc35Wym1UPIpORFcGK2EWZFfV8sI6CxGT29_LnsY6A7BTj0ME73uR0w_INDPMGMa75ccU5f2Bd0Ctgl7O3igcaDv0Za4m_uEdGunWIYz3bQT4GE0z7gHXKgdAr2zIabpHtCOyzu6oVuELvZxsKV_B2PC6Rl50touw_NjPiNfPn7YXV5VN7efri83N5UXWk2VAw8chBYCFDjOAgMJwTjupKuV4szWljnFjFBBSmPYukgR1ty1QWura3lGXh_2li-_z5Cnpo_ZQ9fZAdKcG6ONEVIwWcjzA-nLLxmhbUaMfbm44ax58KB58KD540GBXx7Xzq6H8A_9K3oBXh0Bm73tWiwyxvyfq-VaSsnlb0FeknI</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>SCHELLART, Nico A. M</creator><creator>REITS, Dik</creator><creator>VAN DER KLEIJ, Adrian J</creator><creator>STALPERS, Lukas J. A</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report</title><author>SCHELLART, Nico A. M ; REITS, Dik ; VAN DER KLEIJ, Adrian J ; STALPERS, Lukas J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-bece1e2722e5eb10d0e3ed8b1b3b45510a4a0b50825d338806543d61bfd77a743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - physiopathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - surgery</topic><topic>Cognition</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperbaric Oxygenation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHELLART, Nico A. M</creatorcontrib><creatorcontrib>REITS, Dik</creatorcontrib><creatorcontrib>VAN DER KLEIJ, Adrian J</creatorcontrib><creatorcontrib>STALPERS, Lukas J. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHELLART, Nico A. M</au><au>REITS, Dik</au><au>VAN DER KLEIJ, Adrian J</au><au>STALPERS, Lukas J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>117</volume><issue>15</issue><spage>3434</spage><epage>3444</epage><pages>3434-3444</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Cognitive performance often is impaired permanently in long-term brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may result in improved functionality of damaged tissue. In this pilot study, clinical neurophysiologic tests were used to assess the effect of HBOT on brain performance.
Ten long-term brain tumor survivors received HBOT for severe cognitive deficits after neurosurgery and radiosurgery. Patients were tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a quantitative electroencephalographic (EEG) examination, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory performance, and 2 cognitive tests, the number connection test (NCT) and the continuous reaction time test (CRTT). Late event-related components (LERCs) of averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from whole-head activity maps. For comparison, a control group of healthy individuals (no HBOT) also were investigated.
After HBOT, the amplitude of the LERC with the longest latency, P3b (involved in object interpretation) was improved significantly (P = .02). The amplitudes of the N200 (occipital, negative) and the intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of a small, positive, occipital visual component did not change. Neither latencies nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) latencies were longer in survivors than in healthy individuals. The NCT produced inconclusive results, but the IQCODE revealed an improvement. When outcomes of the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT appeared to provide substantial improvement (P<.006).
On the basis of the current results, the authors concluded tentatively that HBOT improves neurophysiologic performance in long-term brain tumor survivors.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>21287528</pmid><doi>10.1002/cncr.25874</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Brain Neoplasms - physiopathology Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Cognition Electroencephalography Female Humans Hyperbaric Oxygenation Male Medical sciences Middle Aged Neurology Surveys and Questionnaires Tumors Tumors of the nervous system. Phacomatoses |
| title | Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report |
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