Efficacy and Safety of Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Compared with Exenatide Twice Daily and Sitagliptin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Background: Long-acting glucagon-like peptide-1 receptor agonists (LA-GLP-1RAs) may deliver additional therapeutic benefits over other available incretin-based therapies. Objective: To pool results of randomized controlled trials comparing the efficacy and safely of maximum dose LA-GLP-1RAs (liraglu...

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Veröffentlicht in:	The Annals of pharmacotherapy 2011-07, Vol.45 (7-8), p.850-860
Hauptverfasser:	Pinelli, Nicole R, Hurren, Kathryn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - adverse effects Delayed-Action Preparations - therapeutic use Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dipeptidyl-Peptidase IV Inhibitors - administration & dosage Dipeptidyl-Peptidase IV Inhibitors - adverse effects Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Female Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - adverse effects Glucagon-Like Peptide 1 - agonists Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - therapeutic use Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin A - analysis Humans Hyperglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Incretins - administration & dosage Incretins - adverse effects Incretins - agonists Incretins - therapeutic use Liraglutide Male Middle Aged Peptides - administration & dosage Peptides - adverse effects Peptides - therapeutic use Pyrazines - adverse effects Pyrazines - therapeutic use Randomized Controlled Trials as Topic Receptors, Glucagon - agonists Sitagliptin Phosphate Triazoles - adverse effects Triazoles - therapeutic use Venoms - administration & dosage Venoms - adverse effects Venoms - therapeutic use
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