Investigation of Correlation Among Safety Biomarkers in Serum, Histopathological Examination, and Toxicogenomics

This article addresses the issue of miscorrelation between hepatic injury biomarkers and histopathological findings in the drug development context. Our studies indicate that the use of toxicogenomics can aid in the drug development decision-making process associated with such miscorrelated data. BL...

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Veröffentlicht in:	International journal of toxicology 2011-05, Vol.30 (3), p.300-312
Hauptverfasser:	Wang, Tao, Papoutsi, Maria, Wiesmann, Marion, DeCristofaro, Marc, Keselica, M. Craig, Skuba, Elizabeth, Spaet, Robert, Markovits, Judit, Wolf, Armin, Moulin, Pierre, Pognan, Francois, Vancutsem, Paul, Petryk, Lew, Sutton, James, Chibout, Salah-Dine, Kluwe, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alanine Transaminase - genetics Animals Aspartate Aminotransferases - blood Aspartate Aminotransferases - genetics Benzothiazoles - toxicity Biomarkers - blood Down-Regulation - drug effects Gene Expression Profiling Humans Liver - drug effects Liver - enzymology Liver - pathology Macaca fascicularis Pharmacogenetics Picolinic Acids - toxicity Rats Rats, Wistar RNA, Messenger - genetics Toxicity Tests Up-Regulation - drug effects
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