Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms

B-type natriuretic peptide (BNP) is an endogenous peptide produced under physiological and pathological conditions mainly by ventricular myocytes. It has natriuretic, diuretic, blood pressure-lowering, and antifibrotic actions that could mediate cardiorenal protection in cardiovascular diseases. In...

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Veröffentlicht in:	Circulation. Heart failure 2011-07, Vol.4 (4), p.483-495
Hauptverfasser:	Moilanen, Anne-Mari, Rysä, Jaana, Mustonen, Erja, Serpi, Raisa, Aro, Jani, Tokola, Heikki, Leskinen, Hanna, Manninen, Aki, Levijoki, Jouko, Vuolteenaho, Olli, Ruskoaho, Heikki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Angiotensin II - adverse effects Animals Collagen Type III - metabolism Disease Models, Animal Fibrosis - physiopathology Gene Transfer Techniques Genetic Therapy - methods Humans Hypertension - chemically induced Hypertension - complications Hypertension - physiopathology Ligation Male Myocardial Infarction - complications Myocardial Infarction - etiology Myocardial Infarction - physiopathology Natriuretic Peptide, Brain - genetics Natriuretic Peptide, Brain - physiology Neovascularization, Physiologic - physiology Organothiophosphorus Compounds - metabolism Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - therapy Ventricular Remodeling
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