Intestinal transplantation: Current status and future directions
Three decades after the first intestinal transplant was performed in humans, this life‐saving procedure has come of age and now offers hope of long‐term survival in a small group of patients with life‐threatening complications of intestinal failure and parenteral nutrition. Success rates have greatl...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2011-08, Vol.26 (8), p.1221-1228 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Garg, Mayur Jones, Robert M Vaughan, Rhys B Testro, Adam G |
| description | Three decades after the first intestinal transplant was performed in humans, this life‐saving procedure has come of age and now offers hope of long‐term survival in a small group of patients with life‐threatening complications of intestinal failure and parenteral nutrition. Success rates have greatly improved, largely through advances in immunosuppression protocols, improved surgical technique and postoperative care, and accumulated experience. Management of the intestinal transplant recipient entails careful surveillance, prevention, and treatment of rejection and infection, as well as optimization of feeding and nutrition. With this approach, survival and quality of life are demonstrably improved, such that intestinal transplantation is now an established and accepted procedure for this very select group of highly‐complex patients. |
| doi_str_mv | 10.1111/j.1440-1746.2011.06783.x |
| format | Article |
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Success rates have greatly improved, largely through advances in immunosuppression protocols, improved surgical technique and postoperative care, and accumulated experience. Management of the intestinal transplant recipient entails careful surveillance, prevention, and treatment of rejection and infection, as well as optimization of feeding and nutrition. With this approach, survival and quality of life are demonstrably improved, such that intestinal transplantation is now an established and accepted procedure for this very select group of highly‐complex patients.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2011.06783.x</identifier><identifier>PMID: 21595748</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Gastroenterology. Liver. Pancreas. Abdomen ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; Graft Survival ; Humans ; immunosuppression ; Immunosuppression - trends ; Intensive care medicine ; Intestinal Diseases - surgery ; intestinal failure ; intestinal rehabilitation ; intestinal transplant ; Intestines - transplantation ; liver-intestine transplant ; Medical sciences ; Miscellaneous ; multivisceral transplant ; Organ Transplantation - adverse effects ; Organ Transplantation - trends ; Other diseases. Semiology ; parenteral nutrition ; Parenteral Nutrition, Home - adverse effects ; Quality of Life ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Stomach. Duodenum. 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Success rates have greatly improved, largely through advances in immunosuppression protocols, improved surgical technique and postoperative care, and accumulated experience. Management of the intestinal transplant recipient entails careful surveillance, prevention, and treatment of rejection and infection, as well as optimization of feeding and nutrition. With this approach, survival and quality of life are demonstrably improved, such that intestinal transplantation is now an established and accepted procedure for this very select group of highly‐complex patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>immunosuppression</subject><subject>Immunosuppression - trends</subject><subject>Intensive care medicine</subject><subject>Intestinal Diseases - surgery</subject><subject>intestinal failure</subject><subject>intestinal rehabilitation</subject><subject>intestinal transplant</subject><subject>Intestines - transplantation</subject><subject>liver-intestine transplant</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>multivisceral transplant</subject><subject>Organ Transplantation - adverse effects</subject><subject>Organ Transplantation - trends</subject><subject>Other diseases. Semiology</subject><subject>parenteral nutrition</subject><subject>Parenteral Nutrition, Home - adverse effects</subject><subject>Quality of Life</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>immunosuppression</topic><topic>Immunosuppression - trends</topic><topic>Intensive care medicine</topic><topic>Intestinal Diseases - surgery</topic><topic>intestinal failure</topic><topic>intestinal rehabilitation</topic><topic>intestinal transplant</topic><topic>Intestines - transplantation</topic><topic>liver-intestine transplant</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>multivisceral transplant</topic><topic>Organ Transplantation - adverse effects</topic><topic>Organ Transplantation - trends</topic><topic>Other diseases. Semiology</topic><topic>parenteral nutrition</topic><topic>Parenteral Nutrition, Home - adverse effects</topic><topic>Quality of Life</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Success rates have greatly improved, largely through advances in immunosuppression protocols, improved surgical technique and postoperative care, and accumulated experience. Management of the intestinal transplant recipient entails careful surveillance, prevention, and treatment of rejection and infection, as well as optimization of feeding and nutrition. With this approach, survival and quality of life are demonstrably improved, such that intestinal transplantation is now an established and accepted procedure for this very select group of highly‐complex patients.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>21595748</pmid><doi>10.1111/j.1440-1746.2011.06783.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2011-08, Vol.26 (8), p.1221-1228 |
| issn | 0815-9319 1440-1746 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Gastroenterology. Liver. Pancreas. Abdomen Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival Humans immunosuppression Immunosuppression - trends Intensive care medicine Intestinal Diseases - surgery intestinal failure intestinal rehabilitation intestinal transplant Intestines - transplantation liver-intestine transplant Medical sciences Miscellaneous multivisceral transplant Organ Transplantation - adverse effects Organ Transplantation - trends Other diseases. Semiology parenteral nutrition Parenteral Nutrition, Home - adverse effects Quality of Life Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome |
| title | Intestinal transplantation: Current status and future directions |
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