Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of the IDH1-R132H Mutation in Diffuse Glioma Biopsy Specimens

To assess the value of anti-isocitrate dehydrogenase 1 (IDH1) immunohistochemistry for evaluating diffuse gliomas, we analyzed anti-IDH1-R132H immunohistochemistry using monoclonal antibodies DIA-H09 and IMab-1 and IDH1 gene sequencing in formalin-fixed and paraffin-embedded biopsy samples of 95 dif...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2011-08, Vol.70 (8), p.715-723
Hauptverfasser:	Preusser, Matthias, Wöhrer, Adelheid, Stary, Susanne, Höftberger, Romana, Streubel, Berthold, Hainfellner, Johannes A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - genetics Biological and medical sciences Biopsy Brain Neoplasms - diagnosis Brain Neoplasms - genetics Genetic Testing Glioma - diagnosis Glioma - genetics Histidine - genetics Humans Immunohistochemistry - methods Isocitrate Dehydrogenase - genetics Medical sciences Mutation - genetics Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Reproducibility of Results Sequence Analysis - methods
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