Discovery of selective indole-based prostaglandin D₂ receptor antagonist
A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure–activity rela...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2011-08, Vol.19 (15), p.4574-4588 |
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| container_end_page | 4588 |
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| container_issue | 15 |
| container_start_page | 4574 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 19 |
| creator | Iwahashi, Maki Shimabukuro, Atsushi Onoda, Takahiro Matsunaga, Yoko Okada, Yutaka Matsumoto, Ryoji Nambu, Fumio Nakai, Hisao Toda, Masaaki |
| description | A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure–activity relationship study is presented. |
| doi_str_mv | 10.1016/j.bmc.2011.06.014 |
| format | Article |
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Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure–activity relationship study is presented.</description><subject>Animals</subject><subject>antagonists</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability - drug effects</subject><subject>CHO Cells</subject><subject>conjunctiva</subject><subject>Conjunctiva - blood supply</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Drug Discovery</subject><subject>Guinea Pigs</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Indoles - chemistry</subject><subject>Indoles - pharmacology</subject><subject>Medical sciences</subject><subject>permeability</subject><subject>Pharmacology. Drug treatments</subject><subject>prostaglandins</subject><subject>Receptors, Immunologic - antagonists & inhibitors</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Prostaglandin - antagonists & inhibitors</subject><subject>Receptors, Prostaglandin - metabolism</subject><subject>structure-activity relationships</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkblOxDAQhi0EguV4ABpIg6gSZmzHTkq03EKiAGrL8YGyyiaLnUWi5VF5Egy7QOXC3xz_N4QcIhQIKM5mRTM3BQXEAkQByDfIBLngOWM1bpIJ1KLKoarFDtmNcQYAlNe4TXYoSiZpVU7I3UUbzfDmwns2-Cy6zpmxfXNZ29uhc3mjo7PZIgxx1C-d7m3bZxefHx9ZcMYtxiFkuk8_Q9_GcZ9sed1Fd7B-98jz1eXT9Ca_f7i-nZ7f54axcsxL9AKrssZGMy0lSmDQoGPeCkslAhW6aVBYyTwa4UWFPCVk3FKBxkrN9sjpqm9a63Xp4qjmKYPr0npuWEZVyYrKioFMJK5IkwLE4LxahHauw7tCUN8G1Uwlg-rboAKhksFUc7Tuvmzmzv5V_CpLwMka0NHozgfdmzb-c5wj5T_Dj1ec14PSLyExz49pUgmA6TAM2BdiHIMf</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Iwahashi, Maki</creator><creator>Shimabukuro, Atsushi</creator><creator>Onoda, Takahiro</creator><creator>Matsunaga, Yoko</creator><creator>Okada, Yutaka</creator><creator>Matsumoto, Ryoji</creator><creator>Nambu, Fumio</creator><creator>Nakai, Hisao</creator><creator>Toda, Masaaki</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Discovery of selective indole-based prostaglandin D₂ receptor antagonist</title><author>Iwahashi, Maki ; Shimabukuro, Atsushi ; Onoda, Takahiro ; Matsunaga, Yoko ; Okada, Yutaka ; Matsumoto, Ryoji ; Nambu, Fumio ; Nakai, Hisao ; Toda, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-51f618591ba3a7717030b1e3fd6d271026abb16d73f1c6f681420134d261cd7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>antagonists</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability - drug effects</topic><topic>CHO Cells</topic><topic>conjunctiva</topic><topic>Conjunctiva - blood supply</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Drug Discovery</topic><topic>Guinea Pigs</topic><topic>Histamine and antagonists. 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| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2011-08, Vol.19 (15), p.4574-4588 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals antagonists Biological and medical sciences Capillary Permeability - drug effects CHO Cells conjunctiva Conjunctiva - blood supply Cricetinae Cricetulus Drug Discovery Guinea Pigs Histamine and antagonists. Allergy Humans Indoles - chemistry Indoles - pharmacology Medical sciences permeability Pharmacology. Drug treatments prostaglandins Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - metabolism Receptors, Prostaglandin - antagonists & inhibitors Receptors, Prostaglandin - metabolism structure-activity relationships |
| title | Discovery of selective indole-based prostaglandin D₂ receptor antagonist |
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