Evaluation of a method to measure long term cortisol levels
Hair cortisol is positively correlated with waist-to-hip ratio and corresponds with clinical course in a patient with Cushing's disease, suggesting that hair cortisol reflects cortisol exposure at the tissue level. [Display omitted] ► Cortisol levels in scalp hair were measured in 195 healthy i...
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| Veröffentlicht in: | Steroids 2011-09, Vol.76 (10), p.1032-1036 |
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| creator | Manenschijn, Laura Koper, Jan W. Lamberts, Steven W.J. van Rossum, Elisabeth F.C. |
| description | Hair cortisol is positively correlated with waist-to-hip ratio and corresponds with clinical course in a patient with Cushing's disease, suggesting that hair cortisol reflects cortisol exposure at the tissue level.
[Display omitted]
► Cortisol levels in scalp hair were measured in 195 healthy individuals, 9 hypercortisolemic patients and 1 hypocortisolemic patient. ► Hair cortisol levels are positively correlated with waist-hip-ratio. ► There is no decline in cortisol levels in consecutive segments of long hair. ► Cortisol levels in hair are slightly influenced by hair treatment. ► Cortisol levels in scalp hair of patients with Cushing's syndrome are increased and correspond to clinical course.
Elevated levels of cortisol are known to induce various symptoms and diseases, e.g. abdominal obesity, type 2 diabetes, osteoporosis and cardiovascular disease. Measuring serum, saliva and urine cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels. The aim of this study was to investigate whether hair cortisol is a feasible parameter to measure cortisol exposure.
We collected hair samples of 195 healthy individuals, 9 hypercortisolemic and one hypocortisolemic patient and measured hair cortisol levels. Cortisol was extracted from scalp hair using methanol and cortisol levels were measured using a salivary ELISA kit. Measurement of waist and hip circumferences and blood pressure was performed in 46 healthy subjects.
We found a positive correlation between hair cortisol and both waist circumference (
r
=
0.392,
p
=
0.007) and waist-to-hip ratio (WHR) (
r
=
0.425,
p
=
0.003). No correlations were found between hair cortisol levels and BMI, blood pressure or age. There was no decline in cortisol levels in six consecutive hair segments. Hair cortisol levels were elevated in patients with known hypercortisolism (
p
<
0.0001).
Hair cortisol was positively correlated with WHR, suggesting that hair cortisol reflects cortisol exposure at tissue level, which was also supported by elevated hair cortisol levels in hypercortisolemic patients and concordance between hair cortisol levels and clinical disease course. Cortisol levels in hair are slightly influenced by hair treatment but not by natural hair colour, use of hair products, gender or age. |
| doi_str_mv | 10.1016/j.steroids.2011.04.005 |
| format | Article |
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[Display omitted]
► Cortisol levels in scalp hair were measured in 195 healthy individuals, 9 hypercortisolemic patients and 1 hypocortisolemic patient. ► Hair cortisol levels are positively correlated with waist-hip-ratio. ► There is no decline in cortisol levels in consecutive segments of long hair. ► Cortisol levels in hair are slightly influenced by hair treatment. ► Cortisol levels in scalp hair of patients with Cushing's syndrome are increased and correspond to clinical course.
Elevated levels of cortisol are known to induce various symptoms and diseases, e.g. abdominal obesity, type 2 diabetes, osteoporosis and cardiovascular disease. Measuring serum, saliva and urine cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels. The aim of this study was to investigate whether hair cortisol is a feasible parameter to measure cortisol exposure.
We collected hair samples of 195 healthy individuals, 9 hypercortisolemic and one hypocortisolemic patient and measured hair cortisol levels. Cortisol was extracted from scalp hair using methanol and cortisol levels were measured using a salivary ELISA kit. Measurement of waist and hip circumferences and blood pressure was performed in 46 healthy subjects.
We found a positive correlation between hair cortisol and both waist circumference (
r
=
0.392,
p
=
0.007) and waist-to-hip ratio (WHR) (
r
=
0.425,
p
=
0.003). No correlations were found between hair cortisol levels and BMI, blood pressure or age. There was no decline in cortisol levels in six consecutive hair segments. Hair cortisol levels were elevated in patients with known hypercortisolism (
p
<
0.0001).
Hair cortisol was positively correlated with WHR, suggesting that hair cortisol reflects cortisol exposure at tissue level, which was also supported by elevated hair cortisol levels in hypercortisolemic patients and concordance between hair cortisol levels and clinical disease course. Cortisol levels in hair are slightly influenced by hair treatment but not by natural hair colour, use of hair products, gender or age.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/j.steroids.2011.04.005</identifier><identifier>PMID: 21515299</identifier><identifier>CODEN: STEDAM</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Abdominal obesity ; Adolescent ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Biological and medical sciences ; Blood Pressure ; Cortisol ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; Female ; Fundamental and applied biological sciences. Psychology ; Hair - chemistry ; Humans ; Hydrocortisone - chemistry ; Hypercortisolism ; Hypocortisolism ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Obesity ; Scalp hair ; Vertebrates: endocrinology ; Waist-Hip Ratio ; Young Adult</subject><ispartof>Steroids, 2011-09, Vol.76 (10), p.1032-1036</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-4b83a277480d9598c2fefc26ae1ee164312cf8fb185d64c463aa2c47e66cee093</citedby><cites>FETCH-LOGICAL-c463t-4b83a277480d9598c2fefc26ae1ee164312cf8fb185d64c463aa2c47e66cee093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039128X11001383$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24371123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21515299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manenschijn, Laura</creatorcontrib><creatorcontrib>Koper, Jan W.</creatorcontrib><creatorcontrib>Lamberts, Steven W.J.</creatorcontrib><creatorcontrib>van Rossum, Elisabeth F.C.</creatorcontrib><title>Evaluation of a method to measure long term cortisol levels</title><title>Steroids</title><addtitle>Steroids</addtitle><description>Hair cortisol is positively correlated with waist-to-hip ratio and corresponds with clinical course in a patient with Cushing's disease, suggesting that hair cortisol reflects cortisol exposure at the tissue level.
[Display omitted]
► Cortisol levels in scalp hair were measured in 195 healthy individuals, 9 hypercortisolemic patients and 1 hypocortisolemic patient. ► Hair cortisol levels are positively correlated with waist-hip-ratio. ► There is no decline in cortisol levels in consecutive segments of long hair. ► Cortisol levels in hair are slightly influenced by hair treatment. ► Cortisol levels in scalp hair of patients with Cushing's syndrome are increased and correspond to clinical course.
Elevated levels of cortisol are known to induce various symptoms and diseases, e.g. abdominal obesity, type 2 diabetes, osteoporosis and cardiovascular disease. Measuring serum, saliva and urine cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels. The aim of this study was to investigate whether hair cortisol is a feasible parameter to measure cortisol exposure.
We collected hair samples of 195 healthy individuals, 9 hypercortisolemic and one hypocortisolemic patient and measured hair cortisol levels. Cortisol was extracted from scalp hair using methanol and cortisol levels were measured using a salivary ELISA kit. Measurement of waist and hip circumferences and blood pressure was performed in 46 healthy subjects.
We found a positive correlation between hair cortisol and both waist circumference (
r
=
0.392,
p
=
0.007) and waist-to-hip ratio (WHR) (
r
=
0.425,
p
=
0.003). No correlations were found between hair cortisol levels and BMI, blood pressure or age. There was no decline in cortisol levels in six consecutive hair segments. Hair cortisol levels were elevated in patients with known hypercortisolism (
p
<
0.0001).
Hair cortisol was positively correlated with WHR, suggesting that hair cortisol reflects cortisol exposure at tissue level, which was also supported by elevated hair cortisol levels in hypercortisolemic patients and concordance between hair cortisol levels and clinical disease course. Cortisol levels in hair are slightly influenced by hair treatment but not by natural hair colour, use of hair products, gender or age.</description><subject>Abdominal obesity</subject><subject>Adolescent</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cortisol</subject><subject>Endocrinopathies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hair - chemistry</subject><subject>Humans</subject><subject>Hydrocortisone - chemistry</subject><subject>Hypercortisolism</subject><subject>Hypocortisolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Obesity</subject><subject>Scalp hair</subject><subject>Vertebrates: endocrinology</subject><subject>Waist-Hip Ratio</subject><subject>Young Adult</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi0EoqXwClUWxJTgWxxHLCBULlIlFpDYLNc5AVdODHZSibfHVQuMTOcM338uH0JzgguCibhcF3GA4G0TC4oJKTAvMC4P0JTISualFNUhmmLM6pxQ-TpBJzGuMcaC1fQYTSgpSUnreoquFhvtRj1Y32e-zXTWwfDum2zwqdNxDJA5379laVmXGR8GG73LHGzAxVN01GoX4WxfZ-jlbvF8-5Avn-4fb2-WueGCDTlfSaZpVXGJm7qspaEttIYKDQSACM4INa1sV0SWjeDbjNbU8AqEMAC4ZjN0sZv7EfznCHFQnY0GnNM9-DGq9DGtJMM0kWJHmuBjDNCqj2A7Hb4UwWrrTa3Vjze19aYwV8lbCs73K8ZVB81v7EdUAs73gI5Guzbo3tj4x3FWEUJZ4q53XPIDGwtBRWOhN9DYAGZQjbf_3fINgt-O9g</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Manenschijn, Laura</creator><creator>Koper, Jan W.</creator><creator>Lamberts, Steven W.J.</creator><creator>van Rossum, Elisabeth F.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Evaluation of a method to measure long term cortisol levels</title><author>Manenschijn, Laura ; Koper, Jan W. ; Lamberts, Steven W.J. ; van Rossum, Elisabeth F.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-4b83a277480d9598c2fefc26ae1ee164312cf8fb185d64c463aa2c47e66cee093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal obesity</topic><topic>Adolescent</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cortisol</topic><topic>Endocrinopathies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Hydrocortisone - chemistry</topic><topic>Hypercortisolism</topic><topic>Hypocortisolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Obesity</topic><topic>Scalp hair</topic><topic>Vertebrates: endocrinology</topic><topic>Waist-Hip Ratio</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manenschijn, Laura</creatorcontrib><creatorcontrib>Koper, Jan W.</creatorcontrib><creatorcontrib>Lamberts, Steven W.J.</creatorcontrib><creatorcontrib>van Rossum, Elisabeth F.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manenschijn, Laura</au><au>Koper, Jan W.</au><au>Lamberts, Steven W.J.</au><au>van Rossum, Elisabeth F.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a method to measure long term cortisol levels</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>76</volume><issue>10</issue><spage>1032</spage><epage>1036</epage><pages>1032-1036</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><coden>STEDAM</coden><abstract>Hair cortisol is positively correlated with waist-to-hip ratio and corresponds with clinical course in a patient with Cushing's disease, suggesting that hair cortisol reflects cortisol exposure at the tissue level.
[Display omitted]
► Cortisol levels in scalp hair were measured in 195 healthy individuals, 9 hypercortisolemic patients and 1 hypocortisolemic patient. ► Hair cortisol levels are positively correlated with waist-hip-ratio. ► There is no decline in cortisol levels in consecutive segments of long hair. ► Cortisol levels in hair are slightly influenced by hair treatment. ► Cortisol levels in scalp hair of patients with Cushing's syndrome are increased and correspond to clinical course.
Elevated levels of cortisol are known to induce various symptoms and diseases, e.g. abdominal obesity, type 2 diabetes, osteoporosis and cardiovascular disease. Measuring serum, saliva and urine cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels. The aim of this study was to investigate whether hair cortisol is a feasible parameter to measure cortisol exposure.
We collected hair samples of 195 healthy individuals, 9 hypercortisolemic and one hypocortisolemic patient and measured hair cortisol levels. Cortisol was extracted from scalp hair using methanol and cortisol levels were measured using a salivary ELISA kit. Measurement of waist and hip circumferences and blood pressure was performed in 46 healthy subjects.
We found a positive correlation between hair cortisol and both waist circumference (
r
=
0.392,
p
=
0.007) and waist-to-hip ratio (WHR) (
r
=
0.425,
p
=
0.003). No correlations were found between hair cortisol levels and BMI, blood pressure or age. There was no decline in cortisol levels in six consecutive hair segments. Hair cortisol levels were elevated in patients with known hypercortisolism (
p
<
0.0001).
Hair cortisol was positively correlated with WHR, suggesting that hair cortisol reflects cortisol exposure at tissue level, which was also supported by elevated hair cortisol levels in hypercortisolemic patients and concordance between hair cortisol levels and clinical disease course. Cortisol levels in hair are slightly influenced by hair treatment but not by natural hair colour, use of hair products, gender or age.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>21515299</pmid><doi>10.1016/j.steroids.2011.04.005</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abdominal obesity Adolescent Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Biological and medical sciences Blood Pressure Cortisol Endocrinopathies Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Hair - chemistry Humans Hydrocortisone - chemistry Hypercortisolism Hypocortisolism Male Medical sciences Metabolic diseases Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Obesity Scalp hair Vertebrates: endocrinology Waist-Hip Ratio Young Adult |
| title | Evaluation of a method to measure long term cortisol levels |
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