Vascular dysfunction in sepsis: effects of the peroxynitrite decomposition catalyst MnTMPyP

The mechanisms contributing to sepsis vascular dysfunction are not well known. We tested the hypothesis that peroxynitrite scavenging ameliorates sepsis-induced macrovascular and microvascular dysfunction. Male Sprague-Dawley rats were killed 48 h after cecal ligation (n = 15) and puncture or sham p...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2011-08, Vol.36 (2), p.156-161
Hauptverfasser:	Nin, Nicolás, El-Assar, Mariam, Sánchez, Carolina, Ferruelo, Antonio, Sánchez-Ferrer, Alberto, Martínez-Caro, Leticia, Rojas, Yeny, Paula, Marta de, Hurtado, Javier, Esteban, Andrés, Lorente, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Aorta - drug effects Male Metalloporphyrins - pharmacology Microvessels - drug effects Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Norepinephrine - pharmacology Peroxynitrous Acid - metabolism Rats Rats, Sprague-Dawley Sepsis - physiopathology Vasodilator Agents - pharmacology
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