Recombinant factor VIIa affects anastomotic patency of vascular grafts in a rabbit model

Objective Recombinant factor VIIa can decrease postoperative bleeding after cardiac surgery. However, the potential for recombinant factor VIIa to cause early vascular graft occlusion at the site of new vascular anastomoses has not been fully explored. We hypothesized that recombinant factor VIIa wo...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2011-08, Vol.142 (2), p.418-423
Hauptverfasser:	Mazer, C. David, MD, FRCPC, Leong-Poi, Howard, MD, FRCPC, Chhina, Tejinder, MD, FRCPC, Alfardan, Zuhair, MD, Lapierre, Harry, MD, FRCSC, Wang, Zhilan, MSc, Jackson, Zane S., MD, PhD, Qiang, Beiping, MD, Mahoney, James, MD, FRCSC, Latter, David, MD, FRCSC, Hare, Gregory M.T., MD, PhD, FRCPC, Strauss, Bradley H., MD, FRCPC, Teitel, Jerome, MD, FRCPC
Format:	Artikel
Sprache:	eng
Schlagworte:	Anastomosis, Surgical Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bleeding Cardiology. Vascular system Cardiothoracic Surgery Carotid Arteries - surgery Carotid artery Clotting Coagulation factor VIIa Coagulation factors Data processing Dose-Response Relationship, Drug Factor VIIa - administration & dosage Factor VIIa - adverse effects Factor VIIa - pharmacology Graft Occlusion, Vascular - chemically induced Heart Hemoglobin Medical sciences Occlusion pH effects Pneumology Probes prothrombin Rabbits Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Recombinant Proteins - pharmacology Surgery Thorax Thrombosis - chemically induced Ultrasound Vascular Patency - drug effects Veins
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