Adipocytes as a new source of catecholamine production
► Brown and white adipose tissue of rat express catecholamine biosynthetic enzymes. ► Isolated adipocytes produce little amount of norepinephrine and epinephrine. ► Sympathoadrenal system is not the only source of catecholamines in adipose tissue. Catecholamines are an important regulator of lipolys...
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| Veröffentlicht in: | FEBS letters 2011-07, Vol.585 (14), p.2279-2284 |
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| creator | Vargovic, Peter Ukropec, Jozef Laukova, Marcela Cleary, Susannah Manz, Bernhard Pacak, Karel Kvetnansky, Richard |
| description | ► Brown and white adipose tissue of rat express catecholamine biosynthetic enzymes. ► Isolated adipocytes produce little amount of norepinephrine and epinephrine. ► Sympathoadrenal system is not the only source of catecholamines in adipose tissue.
Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine. |
| doi_str_mv | 10.1016/j.febslet.2011.06.001 |
| format | Article |
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Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2011.06.001</identifier><identifier>PMID: 21689652</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adipocyte ; Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - enzymology ; Adipocytes - physiology ; Adipose Tissue, Brown - cytology ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - enzymology ; Adipose Tissue, Brown - physiology ; alpha-Methyltyrosine - pharmacology ; Animals ; Aromatic-L-Amino-Acid Decarboxylases - genetics ; Aromatic-L-Amino-Acid Decarboxylases - metabolism ; Catecholamine biosynthetic enzyme ; Catecholamines - metabolism ; Dopamine beta-Hydroxylase - genetics ; Dopamine beta-Hydroxylase - metabolism ; Endogenous catecholamine ; Enzyme Inhibitors - pharmacology ; Epinephrine - metabolism ; Gene expression ; Humans ; Male ; Mesentery - anatomy & histology ; Norepinephrine - metabolism ; Phenylethanolamine N-Methyltransferase - genetics ; Phenylethanolamine N-Methyltransferase - metabolism ; Rats ; Rats, Sprague-Dawley ; Tyrosine 3-Monooxygenase - antagonists & inhibitors ; Tyrosine 3-Monooxygenase - genetics</subject><ispartof>FEBS letters, 2011-07, Vol.585 (14), p.2279-2284</ispartof><rights>2011 Federation of European Biochemical Societies</rights><rights>FEBS Letters 585 (2011) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-3e982970f4d7d2709db64a10a8cfa2fbf8ff4f1490fa463a898d1d0f2589dd203</citedby><cites>FETCH-LOGICAL-c4762-3e982970f4d7d2709db64a10a8cfa2fbf8ff4f1490fa463a898d1d0f2589dd203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2011.06.001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579311004492$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21689652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vargovic, Peter</creatorcontrib><creatorcontrib>Ukropec, Jozef</creatorcontrib><creatorcontrib>Laukova, Marcela</creatorcontrib><creatorcontrib>Cleary, Susannah</creatorcontrib><creatorcontrib>Manz, Bernhard</creatorcontrib><creatorcontrib>Pacak, Karel</creatorcontrib><creatorcontrib>Kvetnansky, Richard</creatorcontrib><title>Adipocytes as a new source of catecholamine production</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>► Brown and white adipose tissue of rat express catecholamine biosynthetic enzymes. ► Isolated adipocytes produce little amount of norepinephrine and epinephrine. ► Sympathoadrenal system is not the only source of catecholamines in adipose tissue.
Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.</description><subject>Adipocyte</subject><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - enzymology</subject><subject>Adipocytes - physiology</subject><subject>Adipose Tissue, Brown - cytology</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - enzymology</subject><subject>Adipose Tissue, Brown - physiology</subject><subject>alpha-Methyltyrosine - pharmacology</subject><subject>Animals</subject><subject>Aromatic-L-Amino-Acid Decarboxylases - genetics</subject><subject>Aromatic-L-Amino-Acid Decarboxylases - metabolism</subject><subject>Catecholamine biosynthetic enzyme</subject><subject>Catecholamines - metabolism</subject><subject>Dopamine beta-Hydroxylase - genetics</subject><subject>Dopamine beta-Hydroxylase - metabolism</subject><subject>Endogenous catecholamine</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Epinephrine - metabolism</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Male</subject><subject>Mesentery - anatomy & histology</subject><subject>Norepinephrine - metabolism</subject><subject>Phenylethanolamine N-Methyltransferase - genetics</subject><subject>Phenylethanolamine N-Methyltransferase - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tyrosine 3-Monooxygenase - antagonists & inhibitors</subject><subject>Tyrosine 3-Monooxygenase - genetics</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFr3DAQhUVpSDbb_IQW33qyM5K1snQq6bLbBAI5tD0LWRpRLV5ra9kJ--8js9tcUxgYZnjvzfAR8plCRYGK213lsU0djhUDSisQFQD9QBZUNnVZcyE_kkXe8HLVqPqKXKe0gzxLqi7JFaNCKrFiCyLuXDhEexwxFSZX0eNLkeI0WCyiL6wZ0f6JndmHHovDEN1kxxD7T-TCmy7hzbkvye_t5tf6vnx8-vGwvnssLW8EK2tUkqkGPHeNYw0o1wpuKBhpvWG-9dJ77ilX4A0XtZFKOurAs5VUzjGol-TrKTef_jthGvU-JItdZ3qMU9KykVDXTfYuyeqktENMaUCvD0PYm-GoKeiZmN7pMzE9E9MgdOaRfV_OF6Z2j-7N9Q9RFtyfBC-hw-P_pert5jv7OeOf6VMKwLmao76dojAjew446GQD9hZdGNCO2sXwzrevsw6T6A</recordid><startdate>20110721</startdate><enddate>20110721</enddate><creator>Vargovic, Peter</creator><creator>Ukropec, Jozef</creator><creator>Laukova, Marcela</creator><creator>Cleary, Susannah</creator><creator>Manz, Bernhard</creator><creator>Pacak, Karel</creator><creator>Kvetnansky, Richard</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110721</creationdate><title>Adipocytes as a new source of catecholamine production</title><author>Vargovic, Peter ; Ukropec, Jozef ; Laukova, Marcela ; Cleary, Susannah ; Manz, Bernhard ; Pacak, Karel ; Kvetnansky, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-3e982970f4d7d2709db64a10a8cfa2fbf8ff4f1490fa463a898d1d0f2589dd203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipocyte</topic><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - enzymology</topic><topic>Adipocytes - physiology</topic><topic>Adipose Tissue, Brown - cytology</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - enzymology</topic><topic>Adipose Tissue, Brown - physiology</topic><topic>alpha-Methyltyrosine - pharmacology</topic><topic>Animals</topic><topic>Aromatic-L-Amino-Acid Decarboxylases - genetics</topic><topic>Aromatic-L-Amino-Acid Decarboxylases - metabolism</topic><topic>Catecholamine biosynthetic enzyme</topic><topic>Catecholamines - metabolism</topic><topic>Dopamine beta-Hydroxylase - genetics</topic><topic>Dopamine beta-Hydroxylase - metabolism</topic><topic>Endogenous catecholamine</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Epinephrine - metabolism</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Male</topic><topic>Mesentery - anatomy & histology</topic><topic>Norepinephrine - metabolism</topic><topic>Phenylethanolamine N-Methyltransferase - genetics</topic><topic>Phenylethanolamine N-Methyltransferase - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tyrosine 3-Monooxygenase - antagonists & inhibitors</topic><topic>Tyrosine 3-Monooxygenase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vargovic, Peter</creatorcontrib><creatorcontrib>Ukropec, Jozef</creatorcontrib><creatorcontrib>Laukova, Marcela</creatorcontrib><creatorcontrib>Cleary, Susannah</creatorcontrib><creatorcontrib>Manz, Bernhard</creatorcontrib><creatorcontrib>Pacak, Karel</creatorcontrib><creatorcontrib>Kvetnansky, Richard</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vargovic, Peter</au><au>Ukropec, Jozef</au><au>Laukova, Marcela</au><au>Cleary, Susannah</au><au>Manz, Bernhard</au><au>Pacak, Karel</au><au>Kvetnansky, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipocytes as a new source of catecholamine production</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2011-07-21</date><risdate>2011</risdate><volume>585</volume><issue>14</issue><spage>2279</spage><epage>2284</epage><pages>2279-2284</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>► Brown and white adipose tissue of rat express catecholamine biosynthetic enzymes. ► Isolated adipocytes produce little amount of norepinephrine and epinephrine. ► Sympathoadrenal system is not the only source of catecholamines in adipose tissue.
Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>21689652</pmid><doi>10.1016/j.febslet.2011.06.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocyte Adipocytes - cytology Adipocytes - drug effects Adipocytes - enzymology Adipocytes - physiology Adipose Tissue, Brown - cytology Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - enzymology Adipose Tissue, Brown - physiology alpha-Methyltyrosine - pharmacology Animals Aromatic-L-Amino-Acid Decarboxylases - genetics Aromatic-L-Amino-Acid Decarboxylases - metabolism Catecholamine biosynthetic enzyme Catecholamines - metabolism Dopamine beta-Hydroxylase - genetics Dopamine beta-Hydroxylase - metabolism Endogenous catecholamine Enzyme Inhibitors - pharmacology Epinephrine - metabolism Gene expression Humans Male Mesentery - anatomy & histology Norepinephrine - metabolism Phenylethanolamine N-Methyltransferase - genetics Phenylethanolamine N-Methyltransferase - metabolism Rats Rats, Sprague-Dawley Tyrosine 3-Monooxygenase - antagonists & inhibitors Tyrosine 3-Monooxygenase - genetics |
| title | Adipocytes as a new source of catecholamine production |
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