Bacterial DNA promotes proliferation of rat pancreatic stellate cells thorough toll-like receptor 9: potential mechanisms for bacterially induced fibrosis

We hoped to clarify the possible role of CpG DNA as a trigger factor for overt pancreatic inflammation of pancreatic stellate cells (PSCs). Pancreatic stellate cells were isolated from the male Lewis rat. The expression of Toll-like receptor 9 (TLR9) messenger RNA and protein were evaluated by rever...

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Veröffentlicht in:	Pancreas 2011-08, Vol.40 (6), p.823-831
Hauptverfasser:	Nakamura, Taichi, Ito, Tetsuhide, Oono, Takamasa, Igarashi, Hisato, Fujimori, Nao, Uchida, Masahiko, Niina, Yusuke, Yasuda, Mikihiko, Suzuki, Koichi, Takayanagi, Ryoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Movement Cell Proliferation DNA Primers - genetics DNA, Bacterial - immunology Endocytosis Fibrosis Immunity, Innate In Vitro Techniques Ligands Male MAP Kinase Signaling System Models, Immunological Oligodeoxyribonucleotides - immunology Pancreatic Stellate Cells - immunology Pancreatic Stellate Cells - metabolism Pancreatic Stellate Cells - pathology Pancreatitis, Chronic - etiology Pancreatitis, Chronic - pathology Rats Rats, Inbred Lew RNA, Messenger - genetics RNA, Messenger - metabolism Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism
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