Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

► Tau phosphorylation and neuronal apoptosis were induced by OKA, an inhibitor of PP2A. ► Lithium and 6-BIO prevented OKA-induced tau phosphorylation and neuronal apoptosis. ► Silencing of GSK3β by hairpin siRNA reversed tau phosphorylation and neuronal apoptosis. ► Inhibition of DYRK1A and CDK5 fai...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurochemistry international 2011-08, Vol.59 (2), p.235-250
Hauptverfasser:	Martin, Ludovic, Page, Guylene, Terro, Faraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Fundamental and applied biological sciences. Psychology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK3β Neurons - pathology Phosphorylation PP2A Protein Phosphatase 2 - antagonists & inhibitors Rats Rats, Wistar Tau neurons tau Proteins - metabolism Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!