Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
Abstract Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divide...
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| Veröffentlicht in: | Archives of oral biology 2011-08, Vol.56 (8), p.752-760 |
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| creator | Barros, Simone Souza Lobão Veras Henriques, Águida Cristina Gomes Pereira, Karuza Maria Alves de Medeiros, Ana Myriam Costa Galvão, Hébel Cavalcanti Freitas, Roseana de Almeida |
| description | Abstract Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy ( n = 17) and high grade malignancy ( n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 ( P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 ( P < 0.05) and MMP-26 ( P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue. |
| doi_str_mv | 10.1016/j.archoralbio.2010.11.022 |
| format | Article |
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Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy ( n = 17) and high grade malignancy ( n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 ( P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 ( P < 0.05) and MMP-26 ( P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2010.11.022</identifier><identifier>PMID: 21255765</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Carcinoma ; Carcinoma, Squamous Cell - pathology ; Cell Nucleus - ultrastructure ; Dentistry ; Disease Progression ; Humans ; Immunohistochemistry ; Inflammation - pathology ; Keratins - analysis ; Lip Neoplasms - pathology ; Matrix Metalloproteinase 1 - analysis ; Matrix Metalloproteinase 2 - analysis ; Matrix Metalloproteinase 7 - analysis ; Matrix Metalloproteinase 9 - analysis ; Matrix metalloproteinases ; Matrix Metalloproteinases - analysis ; Matrix Metalloproteinases, Secreted - analysis ; Neoplasm Invasiveness ; Stromal Cells - pathology ; Tongue Neoplasms - pathology</subject><ispartof>Archives of oral biology, 2011-08, Vol.56 (8), p.752-760</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-ecc7e4e95f0e1c822ad7c839002e03e3b92d2c439f6836792b6b423ba2be930e3</citedby><cites>FETCH-LOGICAL-c548t-ecc7e4e95f0e1c822ad7c839002e03e3b92d2c439f6836792b6b423ba2be930e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2010.11.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21255765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barros, Simone Souza Lobão Veras</creatorcontrib><creatorcontrib>Henriques, Águida Cristina Gomes</creatorcontrib><creatorcontrib>Pereira, Karuza Maria Alves</creatorcontrib><creatorcontrib>de Medeiros, Ana Myriam Costa</creatorcontrib><creatorcontrib>Galvão, Hébel Cavalcanti</creatorcontrib><creatorcontrib>Freitas, Roseana de Almeida</creatorcontrib><title>Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy ( n = 17) and high grade malignancy ( n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 ( P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 ( P < 0.05) and MMP-26 ( P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.</description><subject>Advanced Basic Science</subject><subject>Carcinoma</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Dentistry</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation - pathology</subject><subject>Keratins - analysis</subject><subject>Lip Neoplasms - pathology</subject><subject>Matrix Metalloproteinase 1 - analysis</subject><subject>Matrix Metalloproteinase 2 - analysis</subject><subject>Matrix Metalloproteinase 7 - analysis</subject><subject>Matrix Metalloproteinase 9 - analysis</subject><subject>Matrix metalloproteinases</subject><subject>Matrix Metalloproteinases - analysis</subject><subject>Matrix Metalloproteinases, Secreted - analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Stromal Cells - pathology</subject><subject>Tongue Neoplasms - pathology</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuPFCEUhYnROO3oXzC4clUtj64q2JiYjo9JJnGhrglF3bJpefQANc78eyE9GuPKFYGcc-_hOwi9omRLCR3eHLc6mUNM2k02bhlp73RLGHuENlSMsqM9GR6jDSGEd1IO8gI9y_lYr_0w0KfoglHW9-PQb1C68n4N8WBzieYA3hrtMNydEuRsY8BxwV6XZO-wh6Kdi6cUC9igM2RsA843q_ZxzdiAc9jUXDZEr5uvHACXGL6vgHWYsYs_IWFnT8_Rk0W7DC8ezkv07cP7r_tP3fXnj1f7d9ed6XeidGDMCDuQ_UKAGsGYnkcjuCSEAeHAJ8lmZnZcLoPgwyjZNEw7xifNJpCcAL9Er89za-SbFXJR3uYWUweoiZUYBWFCSlGV8qw0KeacYFGnZL1O94oS1Yiro_qLuGrEFaWqEq_elw9b1snD_Mf5G3EV7M8CqH-9tZBUNhaCgdkmMEXN0f7Xmrf_TDHOhtbWD7iHfIxrChWmoiozRdSXVn1rnlLSah_5L_9jr8E</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Barros, Simone Souza Lobão Veras</creator><creator>Henriques, Águida Cristina Gomes</creator><creator>Pereira, Karuza Maria Alves</creator><creator>de Medeiros, Ana Myriam Costa</creator><creator>Galvão, Hébel Cavalcanti</creator><creator>Freitas, Roseana de Almeida</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip</title><author>Barros, Simone Souza Lobão Veras ; Henriques, Águida Cristina Gomes ; Pereira, Karuza Maria Alves ; de Medeiros, Ana Myriam Costa ; Galvão, Hébel Cavalcanti ; Freitas, Roseana de Almeida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-ecc7e4e95f0e1c822ad7c839002e03e3b92d2c439f6836792b6b423ba2be930e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Advanced Basic Science</topic><topic>Carcinoma</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Dentistry</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation - pathology</topic><topic>Keratins - analysis</topic><topic>Lip Neoplasms - pathology</topic><topic>Matrix Metalloproteinase 1 - analysis</topic><topic>Matrix Metalloproteinase 2 - analysis</topic><topic>Matrix Metalloproteinase 7 - analysis</topic><topic>Matrix Metalloproteinase 9 - analysis</topic><topic>Matrix metalloproteinases</topic><topic>Matrix Metalloproteinases - analysis</topic><topic>Matrix Metalloproteinases, Secreted - analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Stromal Cells - pathology</topic><topic>Tongue Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barros, Simone Souza Lobão Veras</creatorcontrib><creatorcontrib>Henriques, Águida Cristina Gomes</creatorcontrib><creatorcontrib>Pereira, Karuza Maria Alves</creatorcontrib><creatorcontrib>de Medeiros, Ana Myriam Costa</creatorcontrib><creatorcontrib>Galvão, Hébel Cavalcanti</creatorcontrib><creatorcontrib>Freitas, Roseana de Almeida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barros, Simone Souza Lobão Veras</au><au>Henriques, Águida Cristina Gomes</au><au>Pereira, Karuza Maria Alves</au><au>de Medeiros, Ana Myriam Costa</au><au>Galvão, Hébel Cavalcanti</au><au>Freitas, Roseana de Almeida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>56</volume><issue>8</issue><spage>752</spage><epage>760</epage><pages>752-760</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy ( n = 17) and high grade malignancy ( n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 ( P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 ( P < 0.05) and MMP-26 ( P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21255765</pmid><doi>10.1016/j.archoralbio.2010.11.022</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced Basic Science Carcinoma Carcinoma, Squamous Cell - pathology Cell Nucleus - ultrastructure Dentistry Disease Progression Humans Immunohistochemistry Inflammation - pathology Keratins - analysis Lip Neoplasms - pathology Matrix Metalloproteinase 1 - analysis Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 7 - analysis Matrix Metalloproteinase 9 - analysis Matrix metalloproteinases Matrix Metalloproteinases - analysis Matrix Metalloproteinases, Secreted - analysis Neoplasm Invasiveness Stromal Cells - pathology Tongue Neoplasms - pathology |
| title | Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
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