Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

Store-operated calcium entry (SOCE) is an important Ca²⁺ entry pathway that regulates many cell functions. Upon store depletion, STIM1, a transmembrane protein located in the endoplasmic reticulum (ER), aggregates and relocates close to the plasma membrane (PM) where it activates store-operated calc...

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Veröffentlicht in:	Journal of cell science 2010-09, Vol.123 (18), p.3084-3093
Hauptverfasser:	Pozo-Guisado, Eulalia, Campbell, David G, Deak, Maria, Álvarez-Barrientos, Alberto, Morrice, Nicholas A, Álvarez, Ignacio S, Alessi, Dario R, Martín-Romero, Francisco Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Biological Transport Calcium - metabolism Cell Line Cell Membrane - genetics Cell Membrane - metabolism Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Humans Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Molecular Sequence Data Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phosphorylation Stromal Interaction Molecule 1
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