Early Neonatal Experience of Long-Evans Rats Results in Long-lasting Changes in Reactivity to a Novel Environment and Morphine-induced Sensitization and Tolerance

In Long-Evans rats, daily 3-h separation from the dam during the neonatal period results in enduring alterations in behavioral and neuroendocrine responses to stressors and sensitivity to antinociceptive effects of acute and chronic morphine. We tested whether early neonatal experience alters sensit...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2002-10, Vol.27 (4), p.518-533
Hauptverfasser:	Kalinichev, Mikhail, Easterling, Keith W, Holtzman, Stephen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Brain - drug effects Brain - metabolism Brain - physiopathology Brain research Conditioning Dopamine Drug abuse Drug addictions Drug Tolerance - physiology Environment, Controlled Fundamental and applied biological sciences. Psychology Handling (Psychology) Male Maternal Deprivation Maternal separation Medical sciences Mesolimbic Morphine Morphine - pharmacology Motor Activity - drug effects Motor Activity - physiology Narcotics Neuronal Plasticity - physiology Opioid Peptides - metabolism Opioids Personality. Affectivity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Reaction Time - drug effects Reaction Time - physiology Receptors, Opioid - metabolism Stress Stress, Physiological - metabolism Stress, Physiological - physiopathology Substance-Related Disorders - etiology Substance-Related Disorders - metabolism Substance-Related Disorders - physiopathology Toxicology
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