Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study
Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse. Objective: Our objective was to study associations of maternal...
Gespeichert in:
| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2010-09, Vol.95 (9), p.4227-4234 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4234 |
|---|---|
| container_issue | 9 |
| container_start_page | 4227 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 95 |
| creator | Henrichs, Jens Bongers-Schokking, Jacoba J. Schenk, Jacqueline J. Ghassabian, Akhgar Schmidt, Henk G. Visser, Theo J. Hooijkaas, Herbert de Muinck Keizer-Schrama, Sabine M. P. F. Hofman, Albert Jaddoe, Vincent V. W. Visser, Willy Steegers, Eric A. P. Verhulst, Frank C. de Rijke, Yolanda B. Tiemeier, Henning |
| description | Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse.
Objective: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T4 (FT4) levels across the entire range with cognitive functioning in early childhood.
Design and Setting: We conducted a population-based cohort in The Netherlands.
Participants: Participants included 3659 children and their mothers.
Main Measures: In pregnant women with normal TSH levels at 13 wk gestation (sd = 1.7), mild and severe maternal hypothyroxinemia were defined as FT4 concentrations below the 10th and 5th percentile, respectively. Children’s expressive vocabulary at 18 months was reported by mothers using the MacArthur Communicative Development Inventory. At 30 months, mothers completed the Language Development Survey and the Parent Report of Children’s Abilities measuring verbal and nonverbal cognitive functioning.
Results: Maternal TSH was not related to the cognitive outcomes. An increase in maternal FT4 predicted a lower risk of expressive language delay at 30 months only. However, both mild and severe maternal hypothyroxinemia was associated with a higher risk of expressive language delay across all ages [odds ratio (OR) = 1.44; 95% confidence interval (CI) = 1.09–1.91; P = 0.010 and OR = 1.80; 95% CI = 1.24–2.61; P = 0.002, respectively]. Severe maternal hypothyroxinemia also predicted a higher risk of nonverbal cognitive delay (OR = 2.03; 95% CI = 1.22–3.39; P = 0.007).
Conclusions: Maternal hypothyroxinemia is a risk factor for cognitive delay in early childhood.
Maternal hypothyroxinemia during early pregnancy is a determinant of verbal and nonverbal cognitive functioning in early childhood. |
| doi_str_mv | 10.1210/jc.2010-0415 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_877600710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>877600710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5459-cce18ebd538f5f74e45eca2debd759c0bef40b31bd9084b3eba1913683533a813</originalsourceid><addsrcrecordid>eNqFkc-L1DAUx4so7rh68yy9iBe7vjTJpPEmw_4QVhRdwVtIk9eZjJ1kNmld-t-b7ozrRTAQQsLnffN4n6J4SeCM1ATebc1ZDQQqYIQ_KhZEMl4JIsXjYgFQk0qK-sdJ8SylLQBhjNOnxUkNnDLBxaIYP-kBo9d9ebOZYnC2vBi9GVzwpR2j8-vyXMd-Kr9EXHvtzVRqb8tVWHs3uF_4QM-k80d4tXG93YRg3-dULC_RY9T3mV_Lb8Nop-fFk073CV8cz9Pi-8X5zeqquv58-XH14boynHFZGYOkwdZy2nS8EwwZR6Nrm58ElwZa7Bi0lLRWQsNaiq0mktBlQzmluiH0tHhzyN3HcDtiGtTOJYN9rz2GMalGiCWAIPBfUnAGNQPOM_n2QJoYUorYqX10Ox0nRUDNRtTWqNmImo1k_NUxeGx3aB_gPwoy8PoI6GR038U8ZZf-crReylrOQezA3YU-K0s_-_EOo9qg7oeNgrzYUjTV_DPIfKvyJjKX0UMZehtMNor7iCmpbRhn7enfXf8GY6K0oQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754024055</pqid></control><display><type>article</type><title>Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Henrichs, Jens ; Bongers-Schokking, Jacoba J. ; Schenk, Jacqueline J. ; Ghassabian, Akhgar ; Schmidt, Henk G. ; Visser, Theo J. ; Hooijkaas, Herbert ; de Muinck Keizer-Schrama, Sabine M. P. F. ; Hofman, Albert ; Jaddoe, Vincent V. W. ; Visser, Willy ; Steegers, Eric A. P. ; Verhulst, Frank C. ; de Rijke, Yolanda B. ; Tiemeier, Henning</creator><creatorcontrib>Henrichs, Jens ; Bongers-Schokking, Jacoba J. ; Schenk, Jacqueline J. ; Ghassabian, Akhgar ; Schmidt, Henk G. ; Visser, Theo J. ; Hooijkaas, Herbert ; de Muinck Keizer-Schrama, Sabine M. P. F. ; Hofman, Albert ; Jaddoe, Vincent V. W. ; Visser, Willy ; Steegers, Eric A. P. ; Verhulst, Frank C. ; de Rijke, Yolanda B. ; Tiemeier, Henning</creatorcontrib><description>Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse.
Objective: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T4 (FT4) levels across the entire range with cognitive functioning in early childhood.
Design and Setting: We conducted a population-based cohort in The Netherlands.
Participants: Participants included 3659 children and their mothers.
Main Measures: In pregnant women with normal TSH levels at 13 wk gestation (sd = 1.7), mild and severe maternal hypothyroxinemia were defined as FT4 concentrations below the 10th and 5th percentile, respectively. Children’s expressive vocabulary at 18 months was reported by mothers using the MacArthur Communicative Development Inventory. At 30 months, mothers completed the Language Development Survey and the Parent Report of Children’s Abilities measuring verbal and nonverbal cognitive functioning.
Results: Maternal TSH was not related to the cognitive outcomes. An increase in maternal FT4 predicted a lower risk of expressive language delay at 30 months only. However, both mild and severe maternal hypothyroxinemia was associated with a higher risk of expressive language delay across all ages [odds ratio (OR) = 1.44; 95% confidence interval (CI) = 1.09–1.91; P = 0.010 and OR = 1.80; 95% CI = 1.24–2.61; P = 0.002, respectively]. Severe maternal hypothyroxinemia also predicted a higher risk of nonverbal cognitive delay (OR = 2.03; 95% CI = 1.22–3.39; P = 0.007).
Conclusions: Maternal hypothyroxinemia is a risk factor for cognitive delay in early childhood.
Maternal hypothyroxinemia during early pregnancy is a determinant of verbal and nonverbal cognitive functioning in early childhood.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2010-0415</identifier><identifier>PMID: 20534757</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Child ; Child Development - physiology ; Cognition - physiology ; Cohort Studies ; Developmental Disabilities - blood ; Developmental Disabilities - etiology ; Endocrinopathies ; Family Characteristics ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypothyroidism - blood ; Hypothyroidism - complications ; Hypothyroidism - physiopathology ; Maternal-Fetal Relations ; Medical sciences ; Mothers ; Pregnancy ; Pregnancy Trimester, First - blood ; Pregnancy Trimester, First - physiology ; Prenatal Exposure Delayed Effects - blood ; Prenatal Exposure Delayed Effects - physiopathology ; Risk Factors ; Thyroid Function Tests ; Thyroid Gland - physiology ; Thyrotropin - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2010-09, Vol.95 (9), p.4227-4234</ispartof><rights>Copyright © 2010 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5459-cce18ebd538f5f74e45eca2debd759c0bef40b31bd9084b3eba1913683533a813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23269295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20534757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henrichs, Jens</creatorcontrib><creatorcontrib>Bongers-Schokking, Jacoba J.</creatorcontrib><creatorcontrib>Schenk, Jacqueline J.</creatorcontrib><creatorcontrib>Ghassabian, Akhgar</creatorcontrib><creatorcontrib>Schmidt, Henk G.</creatorcontrib><creatorcontrib>Visser, Theo J.</creatorcontrib><creatorcontrib>Hooijkaas, Herbert</creatorcontrib><creatorcontrib>de Muinck Keizer-Schrama, Sabine M. P. F.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Jaddoe, Vincent V. W.</creatorcontrib><creatorcontrib>Visser, Willy</creatorcontrib><creatorcontrib>Steegers, Eric A. P.</creatorcontrib><creatorcontrib>Verhulst, Frank C.</creatorcontrib><creatorcontrib>de Rijke, Yolanda B.</creatorcontrib><creatorcontrib>Tiemeier, Henning</creatorcontrib><title>Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse.
Objective: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T4 (FT4) levels across the entire range with cognitive functioning in early childhood.
Design and Setting: We conducted a population-based cohort in The Netherlands.
Participants: Participants included 3659 children and their mothers.
Main Measures: In pregnant women with normal TSH levels at 13 wk gestation (sd = 1.7), mild and severe maternal hypothyroxinemia were defined as FT4 concentrations below the 10th and 5th percentile, respectively. Children’s expressive vocabulary at 18 months was reported by mothers using the MacArthur Communicative Development Inventory. At 30 months, mothers completed the Language Development Survey and the Parent Report of Children’s Abilities measuring verbal and nonverbal cognitive functioning.
Results: Maternal TSH was not related to the cognitive outcomes. An increase in maternal FT4 predicted a lower risk of expressive language delay at 30 months only. However, both mild and severe maternal hypothyroxinemia was associated with a higher risk of expressive language delay across all ages [odds ratio (OR) = 1.44; 95% confidence interval (CI) = 1.09–1.91; P = 0.010 and OR = 1.80; 95% CI = 1.24–2.61; P = 0.002, respectively]. Severe maternal hypothyroxinemia also predicted a higher risk of nonverbal cognitive delay (OR = 2.03; 95% CI = 1.22–3.39; P = 0.007).
Conclusions: Maternal hypothyroxinemia is a risk factor for cognitive delay in early childhood.
Maternal hypothyroxinemia during early pregnancy is a determinant of verbal and nonverbal cognitive functioning in early childhood.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Development - physiology</subject><subject>Cognition - physiology</subject><subject>Cohort Studies</subject><subject>Developmental Disabilities - blood</subject><subject>Developmental Disabilities - etiology</subject><subject>Endocrinopathies</subject><subject>Family Characteristics</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - physiopathology</subject><subject>Maternal-Fetal Relations</subject><subject>Medical sciences</subject><subject>Mothers</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Pregnancy Trimester, First - physiology</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Risk Factors</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - physiology</subject><subject>Thyrotropin - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-L1DAUx4so7rh68yy9iBe7vjTJpPEmw_4QVhRdwVtIk9eZjJ1kNmld-t-b7ozrRTAQQsLnffN4n6J4SeCM1ATebc1ZDQQqYIQ_KhZEMl4JIsXjYgFQk0qK-sdJ8SylLQBhjNOnxUkNnDLBxaIYP-kBo9d9ebOZYnC2vBi9GVzwpR2j8-vyXMd-Kr9EXHvtzVRqb8tVWHs3uF_4QM-k80d4tXG93YRg3-dULC_RY9T3mV_Lb8Nop-fFk073CV8cz9Pi-8X5zeqquv58-XH14boynHFZGYOkwdZy2nS8EwwZR6Nrm58ElwZa7Bi0lLRWQsNaiq0mktBlQzmluiH0tHhzyN3HcDtiGtTOJYN9rz2GMalGiCWAIPBfUnAGNQPOM_n2QJoYUorYqX10Ox0nRUDNRtTWqNmImo1k_NUxeGx3aB_gPwoy8PoI6GR038U8ZZf-crReylrOQezA3YU-K0s_-_EOo9qg7oeNgrzYUjTV_DPIfKvyJjKX0UMZehtMNor7iCmpbRhn7enfXf8GY6K0oQ</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Henrichs, Jens</creator><creator>Bongers-Schokking, Jacoba J.</creator><creator>Schenk, Jacqueline J.</creator><creator>Ghassabian, Akhgar</creator><creator>Schmidt, Henk G.</creator><creator>Visser, Theo J.</creator><creator>Hooijkaas, Herbert</creator><creator>de Muinck Keizer-Schrama, Sabine M. P. F.</creator><creator>Hofman, Albert</creator><creator>Jaddoe, Vincent V. W.</creator><creator>Visser, Willy</creator><creator>Steegers, Eric A. P.</creator><creator>Verhulst, Frank C.</creator><creator>de Rijke, Yolanda B.</creator><creator>Tiemeier, Henning</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201009</creationdate><title>Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study</title><author>Henrichs, Jens ; Bongers-Schokking, Jacoba J. ; Schenk, Jacqueline J. ; Ghassabian, Akhgar ; Schmidt, Henk G. ; Visser, Theo J. ; Hooijkaas, Herbert ; de Muinck Keizer-Schrama, Sabine M. P. F. ; Hofman, Albert ; Jaddoe, Vincent V. W. ; Visser, Willy ; Steegers, Eric A. P. ; Verhulst, Frank C. ; de Rijke, Yolanda B. ; Tiemeier, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5459-cce18ebd538f5f74e45eca2debd759c0bef40b31bd9084b3eba1913683533a813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Development - physiology</topic><topic>Cognition - physiology</topic><topic>Cohort Studies</topic><topic>Developmental Disabilities - blood</topic><topic>Developmental Disabilities - etiology</topic><topic>Endocrinopathies</topic><topic>Family Characteristics</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - physiopathology</topic><topic>Maternal-Fetal Relations</topic><topic>Medical sciences</topic><topic>Mothers</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Pregnancy Trimester, First - physiology</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Risk Factors</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - physiology</topic><topic>Thyrotropin - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henrichs, Jens</creatorcontrib><creatorcontrib>Bongers-Schokking, Jacoba J.</creatorcontrib><creatorcontrib>Schenk, Jacqueline J.</creatorcontrib><creatorcontrib>Ghassabian, Akhgar</creatorcontrib><creatorcontrib>Schmidt, Henk G.</creatorcontrib><creatorcontrib>Visser, Theo J.</creatorcontrib><creatorcontrib>Hooijkaas, Herbert</creatorcontrib><creatorcontrib>de Muinck Keizer-Schrama, Sabine M. P. F.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Jaddoe, Vincent V. W.</creatorcontrib><creatorcontrib>Visser, Willy</creatorcontrib><creatorcontrib>Steegers, Eric A. P.</creatorcontrib><creatorcontrib>Verhulst, Frank C.</creatorcontrib><creatorcontrib>de Rijke, Yolanda B.</creatorcontrib><creatorcontrib>Tiemeier, Henning</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henrichs, Jens</au><au>Bongers-Schokking, Jacoba J.</au><au>Schenk, Jacqueline J.</au><au>Ghassabian, Akhgar</au><au>Schmidt, Henk G.</au><au>Visser, Theo J.</au><au>Hooijkaas, Herbert</au><au>de Muinck Keizer-Schrama, Sabine M. P. F.</au><au>Hofman, Albert</au><au>Jaddoe, Vincent V. W.</au><au>Visser, Willy</au><au>Steegers, Eric A. P.</au><au>Verhulst, Frank C.</au><au>de Rijke, Yolanda B.</au><au>Tiemeier, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2010-09</date><risdate>2010</risdate><volume>95</volume><issue>9</issue><spage>4227</spage><epage>4234</epage><pages>4227-4234</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children’s cognitive development are sparse.
Objective: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T4 (FT4) levels across the entire range with cognitive functioning in early childhood.
Design and Setting: We conducted a population-based cohort in The Netherlands.
Participants: Participants included 3659 children and their mothers.
Main Measures: In pregnant women with normal TSH levels at 13 wk gestation (sd = 1.7), mild and severe maternal hypothyroxinemia were defined as FT4 concentrations below the 10th and 5th percentile, respectively. Children’s expressive vocabulary at 18 months was reported by mothers using the MacArthur Communicative Development Inventory. At 30 months, mothers completed the Language Development Survey and the Parent Report of Children’s Abilities measuring verbal and nonverbal cognitive functioning.
Results: Maternal TSH was not related to the cognitive outcomes. An increase in maternal FT4 predicted a lower risk of expressive language delay at 30 months only. However, both mild and severe maternal hypothyroxinemia was associated with a higher risk of expressive language delay across all ages [odds ratio (OR) = 1.44; 95% confidence interval (CI) = 1.09–1.91; P = 0.010 and OR = 1.80; 95% CI = 1.24–2.61; P = 0.002, respectively]. Severe maternal hypothyroxinemia also predicted a higher risk of nonverbal cognitive delay (OR = 2.03; 95% CI = 1.22–3.39; P = 0.007).
Conclusions: Maternal hypothyroxinemia is a risk factor for cognitive delay in early childhood.
Maternal hypothyroxinemia during early pregnancy is a determinant of verbal and nonverbal cognitive functioning in early childhood.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>20534757</pmid><doi>10.1210/jc.2010-0415</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2010-09, Vol.95 (9), p.4227-4234 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_877600710 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Child Child Development - physiology Cognition - physiology Cohort Studies Developmental Disabilities - blood Developmental Disabilities - etiology Endocrinopathies Family Characteristics Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Hypothyroidism - blood Hypothyroidism - complications Hypothyroidism - physiopathology Maternal-Fetal Relations Medical sciences Mothers Pregnancy Pregnancy Trimester, First - blood Pregnancy Trimester, First - physiology Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - physiopathology Risk Factors Thyroid Function Tests Thyroid Gland - physiology Thyrotropin - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T16%3A38%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20Thyroid%20Function%20during%20Early%20Pregnancy%20and%20Cognitive%20Functioning%20in%20Early%20Childhood:%20The%20Generation%20R%20Study&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Henrichs,%20Jens&rft.date=2010-09&rft.volume=95&rft.issue=9&rft.spage=4227&rft.epage=4234&rft.pages=4227-4234&rft.issn=0021-972X&rft.eissn=1945-7197&rft.coden=JCEMAZ&rft_id=info:doi/10.1210/jc.2010-0415&rft_dat=%3Cproquest_cross%3E877600710%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=754024055&rft_id=info:pmid/20534757&rfr_iscdi=true |