Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

Mutations in Myo7a cause hereditary deafness in mice and humans. We describe the effects of two mutations, Myo7a 6J and Myo7a 4626SB , on mechano-electrical transduction in cochlear hair cells. Both mutations result in two major functional abnormalities that would interfere with sound transduction....

Ausführliche Beschreibung