Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait
Identifying the genes involved in polygenic traits has been difficult. In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the...
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| Veröffentlicht in: | Nature genetics 2002-08, Vol.31 (4), p.349-353 |
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| creator | White, Kevin P Greenspan, Ralph J Toma, Daniel P Hirsch, Jerry |
| description | Identifying the genes involved in polygenic traits has been difficult. In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the behavior have never been identified using this classical model. To identify the individual genes involved in geotaxic response, we used cDNA microarrays to identify candidate genes and assessed fly lines mutant in these genes for behavioral confirmation. We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis. |
| doi_str_mv | 10.1038/ng893 |
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In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the behavior have never been identified using this classical model. To identify the individual genes involved in geotaxic response, we used cDNA microarrays to identify candidate genes and assessed fly lines mutant in these genes for behavioral confirmation. We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng893</identifier><identifier>PMID: 12042820</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animal Genetics and Genomics ; Animals ; Animals, Genetically Modified ; Behavior ; Behavior, Animal - physiology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; DNA, Complementary ; Drosophila ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; Evolution & development ; Experiments ; Female ; Fruits ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Function ; Genes ; Genes. Genome ; Genetic aspects ; Genetics ; Genetics, Behavioral - methods ; Human Genetics ; Human mechanics ; Identification and classification ; Insects ; Molecular and cellular biology ; Molecular genetics ; Mutation ; Oligonucleotide Array Sequence Analysis ; Physiological aspects ; Space life sciences</subject><ispartof>Nature genetics, 2002-08, Vol.31 (4), p.349-353</ispartof><rights>Springer Nature America, Inc. 2002</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c645t-bf2060d5e597ea87f491f9dc066cc8597f8b809f1a96611b5ac2bc80e4f79ca63</citedby><cites>FETCH-LOGICAL-c645t-bf2060d5e597ea87f491f9dc066cc8597f8b809f1a96611b5ac2bc80e4f79ca63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng893$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng893$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13818776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12042820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>White, Kevin P</creatorcontrib><creatorcontrib>Greenspan, Ralph J</creatorcontrib><creatorcontrib>Toma, Daniel P</creatorcontrib><creatorcontrib>Hirsch, Jerry</creatorcontrib><title>Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Identifying the genes involved in polygenic traits has been difficult. In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the behavior have never been identified using this classical model. To identify the individual genes involved in geotaxic response, we used cDNA microarrays to identify candidate genes and assessed fly lines mutant in these genes for behavioral confirmation. We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Behavior</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>DNA, Complementary</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - physiology</subject><subject>Evolution & development</subject><subject>Experiments</subject><subject>Female</subject><subject>Fruits</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Function</subject><subject>Genes</subject><subject>Genes. Genome</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Genetics, Behavioral - methods</subject><subject>Human Genetics</subject><subject>Human mechanics</subject><subject>Identification and classification</subject><subject>Insects</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutation</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Physiological aspects</subject><subject>Space life sciences</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0m1r1TAUAOAiiptzv0CQoqgI3pn0JU0-jvl2YTDw7Ws9TU-6jDapSXq5-_fL7MVyh6jkQ0Ly5CQ5OUlyTMkJJTl_azou8nvJIS0LtqIV5ffjmDC6KkjODpJH3l8RQouC8IfJAc1IkfGMHCY_1i2aoJWWELQ1qVVphwZ9qs3G9hts4yB956y346XuIR2wB2M78AFdlDbAVvs3KaTSDmOP27TBS9ho66BPgwMdHicPFPQej3f9UfLtw_uvZ59W5xcf12en5yvJijKsGpURRtoSS1Eh8EoVgirRSsKYlDxOKt5wIhQFwRilTQkyayQnWKhKSGD5UfJqjjs6-3NCH-pBe4l9vC7ayde8qkohSsKjfPlXWVEhqKj-DSkvcp4xGuGzO_DKTs7E59ZZljEWE19F9HxGHfRYa6NszI-8jVifUp4XGRGkjOrkDyq2FgctrUGl4_zehtd7G6IJuA0dTN7X6y-f_99efN-3L2Yr4-d7h6oenR7AXdeU1LcVV_-quOie7t4-NQO2i9qV2BJoBC-hVw6M1H5xOafxb9iSbR-XTIduSeLdE5_M0ECYHP6ONK_eAM_e8AI</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>White, Kevin P</creator><creator>Greenspan, Ralph J</creator><creator>Toma, Daniel P</creator><creator>Hirsch, Jerry</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait</title><author>White, Kevin P ; Greenspan, Ralph J ; Toma, Daniel P ; Hirsch, Jerry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c645t-bf2060d5e597ea87f491f9dc066cc8597f8b809f1a96611b5ac2bc80e4f79ca63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Behavior</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>DNA, Complementary</topic><topic>Drosophila</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - physiology</topic><topic>Evolution & development</topic><topic>Experiments</topic><topic>Female</topic><topic>Fruits</topic><topic>Fundamental and applied biological sciences. 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In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the behavior have never been identified using this classical model. To identify the individual genes involved in geotaxic response, we used cDNA microarrays to identify candidate genes and assessed fly lines mutant in these genes for behavioral confirmation. We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12042820</pmid><doi>10.1038/ng893</doi><tpages>5</tpages></addata></record> |
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| subjects | Agriculture Animal Genetics and Genomics Animals Animals, Genetically Modified Behavior Behavior, Animal - physiology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research DNA, Complementary Drosophila Drosophila melanogaster Drosophila melanogaster - physiology Evolution & development Experiments Female Fruits Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genes Genes. Genome Genetic aspects Genetics Genetics, Behavioral - methods Human Genetics Human mechanics Identification and classification Insects Molecular and cellular biology Molecular genetics Mutation Oligonucleotide Array Sequence Analysis Physiological aspects Space life sciences |
| title | Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait |
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