PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

Dopamine neurotransmission is associated with high susceptibility to cocaine abuse. Positron emission tomography was used in 12 rhesus macaques to determine if dopamine D2 receptor availability was associated with the rate of cocaine reinforcement, and to study changes in brain dopaminergic function...

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Veröffentlicht in:	Nature neuroscience 2006-08, Vol.9 (8), p.1050-1056
Hauptverfasser:	Nader, Michael A, Morgan, Drake, Gage, H Donald, Nader, Susan H, Calhoun, Tonya L, Buchheimer, Nancy, Ehrenkaufer, Richard, Mach, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Animal Genetics and Genomics Animals Behavior, Addictive Behavior, Animal - physiology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - anatomy & histology Brain - physiology Brain research Brain stimulation Cocaine Cocaine - administration & dosage Cocaine abuse Diagnosis Dopamine Drug abuse Food GABA Modulators - metabolism Health aspects Humans Lorazepam - metabolism Macaca mulatta Male Medicine Monkeys & apes Neurobiology Neurosciences PET imaging Positron-Emission Tomography Psychological aspects Receptors, Dopamine D2 - metabolism Reinforcement (Psychology) Self Administration Time Factors Tomography
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